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| 1 | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?显示文摘Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. | Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 2 | Fluid balance concepts in medicine:Principles and practice显示文摘The regulation of body fluid balance is a key concern in health and disease and comprises three concepts. The first concept pertains to the relationship between total body water(TBW) and total effective solute and is expressed in terms of the tonicity of the body fluids. Disturbances in tonicity are the main factor responsible for changes in cell volume, which can critically affect brain cell function and survival. Solutes distributed almost exclusively in the extracellular compartment(mainly sodium salts) and in the intracellular compartment(mainly potassium salts) contribute to tonicity, while solutes distributed in TBW have no effect on tonicity. The second body fluid balance concept relates to the regulation and measurement of abnormalities of sodium salt balance and extracellular volume. Estimation of extracellular volume is more complex and error prone than measurement of TBW. A key function of extracellular volume, which is defined as the effective arterial blood volume(EABV), is to ensure adequate perfusion of cells and organs. Other factors, including cardiac output, total and regional capacity of both arteries and veins, Starling forces in the capillaries, and gravity also affect the EABV. Collectively, these factors interact closely with extracellular volume and some of them undergo substantial changes in certain acute and chronic severe illnesses. Their changes result not only in extracellular volume expansion, but in the need for a larger extracellular volume compared with that of healthy individuals. Assessing extracellular volume in severe illness is challenging because the estimates of this volume by commonly used methods are prone to large errors in many illnesses. In addition, the optimal extracellular volume may vary from illness to illness, is only partially based on volume measurements by traditional methods, and has not been determined for each illness. Further research is needed to determine optimal extracellular volume levels in several illnesses. For these reasons, extracellular volume in severe illness merits a separate third concept of body fluid balance. | Maria-Eleni Roumelioti Robert H Glew Zeid J Khitan Helbert Rondon-Berrios Christos P Argyropoulos Deepak Malhotra Dominic S Raj Emmanuel I Agaba Mark Rohrscheib Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2018 | World Journal of Nephrology2018，7，1： | 3 |
| 3 | Liver involvement in the drug reaction,eosinophilia,and systemic symptoms syndrome显示文摘First described in 1996,the drug reaction,eosinophilia,and systemic symptoms syndrome(DReSS) is considered,along with Stevens-Johnson syndrome and toxic epidermal necrolysis,a severe cutaneous drug reaction. It is characterized by the presence of a maculopapular erythematous skin eruption,fever,lymphadenopathy,influenza-like symptoms,eosinophilia,and visceral involvement such as hepatitis,pneumonitis,myocarditis,pericarditis,nephritis,and colitis. The prognosis of patients with DReSS is related to the severity of visceral involvement. The mortality ranges from approximately 5% to 10%,and death is mainly due to liver failure,which is also the organ most commonly involved in this syndrome. Although it was previously hypothesized in 1994,DReSS syndrome can lead to reactivation of one or more human herpesvirus family members. Now being included as diagnostic criteria in a proposed diagnostic score system,this reactivation can be detected up to 2-3 wk after DReSS syndrome onset. Other causes of mortality in DReSS syndrome include myocardial or pulmonary lesions and hemophagocytosis. We reviewed the literature of previously reported case-series of DReSS and liver involvement,highlighting the pattern of liver damage,the treatment used,and the outcome. | Sylvia A Martinez-Cabriales Neil H Shear Emmanuel I Gonzalez-Moreno | 2019 | World Journal of Clinical Cases2019，7，6： | 2 |
| 4 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 5 | Respiratory failure in diabetic ketoacidosis显示文摘Respiratory failure complicating the course of diabetic ketoacidosis(DKA)is a source of increased morbidity and mortality.Detection of respiratory failure in DKA requires focused clinical monitoring,careful interpretation of arterial blood gases,and investigation for conditions that can affect adversely the respiration.Conditions that compromise respiratory function caused by DKA can be detected at presentation but are usually more prevalent during treatment.These conditions include deficits of potassium,magnesium and phosphate and hydrostatic or non-hydrostatic pulmonary edema.Conditions not caused by DKA that can worsen respiratory function under the added stress of DKA include infections of the respiratory system,pre-existing respiratory or neuromuscular disease and miscellaneous other conditions.Prompt recognition and management of the conditions that can lead to respiratory failure in DKA may prevent respiratory failure and improve mortality from DKA. | Nikifor K Konstantinov Mark Rohrscheib Emmanuel I Agaba Richard I Dorin Glen H Murata Antonios H Tzamaloukas | 2015 | World Journal of Diabetes2015，6，8： | 2 |
| 6 | Geologically constrained probabilistic mapping of gold potential, Baguio District, Philippines 显示文摘 | Emmanuel J Carranza M Martin H | 2000 | Natural Resources Research2000，9，3： | 1 |
| 7 | Production of recombinant Potato mop-top virus coat protein in Escherichia coli and generation of antisera recognizing native virus protein 显示文摘 | Valerie H Emmanuel J Maryse G | 2003 | Journal of Virology Methods2003，110，： | 1 |
| 8 | Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease显示文摘 | Philippe Mathurin Antoine Hollebecque Laurent Arnalsteen David Buob Emmanuelle Leteurtre Robert Caiazzo Marie Pigeyre Hélène Verkindt Sébastien Dharancy Alexandre Louvet Monique Romon Fran?ois Pattou | 2009 | Gastroenterology2009，，2： | 1 |
| 9 | Rtil-System: A Real-Time Interactive L-System For 3d Interactions With Virtual Plants显示文摘 | Ludovic H Emmanuelle R Paul R | 2012 | Virtual Reality2012，16，2： | 1 |
| 10 | Fluoroquinolone resistance associated with target mutation and active effiux in oropharyngeal isolates of viridans group Streptococci 显示文摘 | FRANCOIS G EMMANUELLE V ANNIE B H | 2000 | Antimicro Agents Chemother2000，44，8： | 1 |
| 11 | Stability ofMoldedpolydimethylsiloxane Microstructures显示文摘 | Emmanuel Delamarche H S Bruno Michel Hans Biebuyck | 1997 | Adv Mater1997，9，9： | 1 |
| 12 | Laparoscopie liver resections: a feasibility study in 30 patients显示文摘 | Daniel C Emmanuel H Renaud H | 2000 | Ann Surg2000，232，6： | 1 |
| 13 | Insights into gene expression profiling of natural resistance to coecidiosis in contras- ting chicken lines显示文摘 | Thomas H Bertrand B Emmanuelle R | 2011 | BMC Proceedings2011，5，4： | 1 |
| 14 | Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors显示文摘 | Salmon Hélène Franciszkiewicz Katarzyna Damotte Diane Dieu-Nosjean Marie-Caroline Validire Pierre Trautmann Alain Mami-Chouaib Fathia Donnadieu Emmanuel | 2012 | EN2012，，3： | 1 |
| 15 | Wear rate of animal-drawn ploughshares in selected Ghanaian soils显示文摘 | Emmanuel Y H Bobobee Kofi Sraku-Lartey | | 0，，93： | 1 |
| 16 | Reducing the cost of HIV antibody testing显示文摘 | Tamashiro H MaskiU W Emmanuel J | 1993 | Lancet1993，342，： | 1 |
| 17 | Indieators for early prediction of outcome in sepsis 显示文摘 | Novomy A Emmanuel K Bartels H | 2005 | Chirurg2005，76，9： | 1 |
| 18 | Noninvasive study of coronary microcirculation response to a cold pressor test显示文摘 | Isabelle Pham Minh‐Tuan Nguyen Paul Valensi Hélène Rousseau Alain Nitenberg Eric Vicaut Emmanuel Cosson | 2015 | Eur J Clin Invest2015，，： | 1 |
| 19 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome 显示文摘 | Christophe G MinH H Emmanuelle C J | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 20 | Reducing the cost of HIV antibody testing显示文摘 | TAMASHIRO H MASKILL W EMMANUEL J | 1993 | Lancet1993，342，： | 1 |
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