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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Thermoregulation what role for UCPs in mammals and birds? 显示文摘 | Mozo J Emre Y Bouillaud F | 2005 | Biosci Rep2005，25，34： | 1 |
| 3 | Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer显示文摘 | Jussuf T Kaifi Emre F | 2005 | J Nail Cancer Inst2005，97，24： | 1 |
| 4 | Pleural effusion as the first sign of multiple myeloma 显示文摘 | Usktil BT Ttirker H Emre Turan F | 2008 | Tuberk Toraks2008，56，43： | 1 |
| 5 | Attenuation of sepsis-related immunoparalysis by continuous venovenous hemofiltration in experimental porcine pancreatitis显示文摘 | Emre F Yekebas MD Claus F | 2001 | Crit Care Med2001，29，7： | 1 |
| 6 | Attenuation of sepsis-related immunoparalysis by continuous venovenous hemofiltration in exper- imental porcine pancreatitis显示文摘 | Emre F Yekebas MD Claus F | 2002 | Crit Care Med2002，30，1： | 1 |
| 7 | Preparation, characterization and H2/O2 selectivity of hyperbranched polyimides containing triazine显示文摘 | Ergun E Emre F B Turgay S | 2005 | Polymer Research2005，12，3： | 1 |
| 8 | Pleural effu- sion as the first sign of multiple myeloma 显示文摘 | Uskul BT Turker H Emre Turan F | 2008 | Tuberkuloz Ve Toraks Dergisi2008，56，4： | 1 |
| 9 | Fenofibrate-induced rhabdomyolysis in a patient with chronic renal failure due to nephrotic syndrome:a rare case report显示文摘 | Erdur F Soyoral F Emre H | 2012 | Clin Biochem2012，45，12： | 1 |
| 10 | Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitia显示文摘 | Emre F Tim S Sharam Z | 2002 | Kidney Int2002，62，5： | 1 |
| 11 | VPS21 encodes a rab5-1ike GTPbinding protein that is required for the sorting ofyeast vacuolar proteins显示文摘 | Horazdovsky B F Busehl G R Emr S D | 1994 | The EMBO Journal1994，13，6： | 1 |
| 12 | VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolarproteins显示文摘 | HORAZDOVSKY B F BUSCH G R EMR S D | 1994 | The EMBO Journal1994，13，： | 1 |
| 13 | Relationship between aortic valve sclerosis and left ventricular hypertrophy in chronic haemodialysis patients 显示文摘 | Turkmen F Emre A Ozdemir A | 2008 | Int Urol Nephrol2008，40，2： | 1 |
| 14 | Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity 显示文摘 | Chen F Ananthanarayanan M Emre S | 2004 | Gastroenterology2004，126，3： | 1 |
| 15 | Long-term follow-up in small duct chronic pancreatitis,a plea for extended drainge by'V-Shaped Excision' of the anterior aspect of the pancreas 显示文摘 | Emre F Y Dean Bogoevski Human Honarpisheh | 2006 | Ann Surg2006，244，6： | 1 |
| 16 | Management of the difficult duodenal stump in penetrat- ing duodenal ulcer disease : a comparative analysis of duode- nojejunostomy with 'classical' stump closure ( Nissen - Bsteh) 显示文摘 | Yogesh K Vashist Emre F Yekebas Florian Gebauer | 2012 | Langenbeck''s archives of surgery2012，397，8： | 1 |
| 17 | L1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma显示文摘瞄准:在胰腺的神经内分泌肿瘤决定 L1 的表示并且相关它与这个肿瘤的分类。方法:我们回顾地在原发性瘤或转移的石蜡节上由免疫组织化学在胰腺的神经内分泌肿瘤的 63 种情况中分析了 L1 表示。染色被过氧化物酶技术对人的 L1 与单音的同种细胞的抗体 UJ127.11 执行。所有肿瘤被分类根据分类同样区分得好的神经内分泌肿瘤和癌或糟糕区分的神经内分泌癌。结果:L1 在 5 被检测(7.9%) 63 个胰腺的神经内分泌肿瘤。(44.4%) 四 9 糟糕区分的癌表示了 L1。相反,仅仅(1.9%) 1 为 L1 54 个区分得好的肿瘤或癌是积极的。没有表示在正常胰腺的织物的 Langerhans 小岛房间被发现。生气桌子分析显示出在 L1 表示和胰(P<0.01 ) 的神经内分泌肿瘤的分类之间的一个重要协会。结论:L1 明确地在被知道有最糟的预后的糟糕区分的胰腺的神经内分泌癌被表示。L1 可能是为与胰腺的神经内分泌癌诊断的病人的风险预言的一个标记。 | Jussuf T Kaifi Ulrich Zinnkann Emre F Yekebas Paulus G Schurr Uta Reichelt Robin Wachowiak Henning C Fiegel Susann Petri Melitta Schachner Jakob RIzbicki | 2006 | World Journal of Gastroenterology2006，12，1： | 1 |
| 18 | Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitis显示文摘 | Emre F Tim Strate Sharam Z | 2002 | Kidney Int2002，62，： | 1 |
| 19 | Postpancreatot- omy hemorrhage; diagnosisand treatment - an analysis in 1669 consecutive pancreati resections显示文摘 | Emre F Yekebas MD Lars Wolfram | 2007 | Ann Surg2007，246，2： | 1 |
| 20 | A droplet-based building block approach for bladder smooth muscle cell ( SMC)proliferation 显示文摘 | Xu F Moon S J Emre A E | 2010 | Biofabrieation2010，2，1： | 1 |
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