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78篇 您的检索式：作者名="Engel Y"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Structural determinants of water permeation through aquaporin-1 显示文摘	MIYAMOTO K MITSUOKA K HIRAI T WALZ T AGRE P HEYMANN J B ENGEL A FUJIYOSHI Y	2000	Nature2000，407，：	1
3	Negative-strand RNA viruses:genetic engineering and applications 显示文摘	PALESE P ZHENG H Y ENGEL O G	1996	Proc Natl Acad Sci USA1996，，11：	1
4	Dynamic regulation of mucus gel thickness in rat duodenum 显示文摘	AKIBA Y GUTH PH ENGEL E	2000	American Journal of Physiology Gastrointestinal and Liver Physiology2000，279，2：	1
5	Mutations of the multi-drug resistance-associated protein ABC transporter gene 5 result in reduction of phytic acid in rice seeds 显示文摘	Xu X H Zhao H J Liu Q L Frank T Engel K H An G Shu Q Y	2009	Theoretical and Applied Genetics2009，119，：	1
6	Management of Data Streams for a Real Time Flood Simulation显示文摘	GADGIL H CHOI J Y ENGEL B	2004	Community Grids Lab Technical Report2004，44，32：	1
7	Computation of bed load using bathymetric data显示文摘	Engel P Lao Y L		0，，03：	1
8	Negative-strand RNA viruses: genetic engineering and applications 显示文摘	Palese P Zheng H Y Engel O G	1996	Proc Natl Acad Sci USA1996，93，11：	1
9	Preparation of ionic liquid based solid-phase microextraction fiber and its application to fo- rensic determination of methamphetamine and amphetamine in hu- man urine显示文摘	HE Y POHLA J ENGEL R	2009	J Chromatogr A2009，1216，24：	1
10	The kernel recur-sive least squares algorithm显示文摘	ENGEL Y MANNOR S MEIR R	2004	IEEE Transactions onSignal Processing2004，52，8：	1
11	Angiotensin-( 1 7) and the G protein-coupled receptor MAS are key players in renal inflammarion显示文摘	Esteban V Heringer-Walther S Sterner-Kock A de Bruin R van den Engel S Wang Y	2009	PLoS One2009，4，：	1
12	Saying 'goodbye' to single-handed practices;what do patients and staff lose or gain显示文摘	van den Hombergh P Engels Y van den Hoogen H		0，，：	1
13	Drug drug interactions of triazole antifungal agents in multimorbid patients and implications for patient care显示文摘	Nivoix Y Ubeaud-Sequier G Engel P	2009	Current Drug Metabolism2009，10，：	1
14	Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications显示文摘	Menges Y Engel J Welters I	1999	Crit Care Med1999，27，4：	1
15	Kinetics of peptide hydrolysisand amino acid decompositionat high temperature显示文摘	Qian Y Engel M H Macko S A	1993	Geochimic Cosmochimicacta1993，57，14：	1
16	A potential role for calcium/calmodulin-dependent protein kinase-related peptide in neuronal apoptosis:in vivo and in vitro evidence显示文摘	SCHENK G J ENGELS B ZHANG Y P	2007	Eur J Neurosci2007，26，12：	1
17	Dynamic regulation of mucus gel thickness in rat duodenum 显示文摘	Akiba Y Guth PH Engel E	2000	Am J Physiol Gastrointest Liver physiol2000，279，2：	1
18	Drug - drug interactions of triazole antifungal agents in multi-morbid patients and implications for patient care 显示文摘	Nivoix Y Ubeaud- Sequier G Engel P	2009	Current Drug Metabolism2009，10，：	1
19	Size effect on springback behavior due to plastic strain gradient hardening in micro bending process of pure aluminum foils 显示文摘	LI H Z DONG X H SHEN Y DIEHL A HAGENAH H ENGEL U MERKLEIN M	2010	Materials Science and Engineering A2010，527，：	1
20	Stable Isotope Analysis at the Molecular Level: A New Approach for Determining the Origins of Amino Acids in the Murchison Meteorite显示文摘	Engel MH Macko SA Qian Y	1995	Adv Space Res1995，15，3：	1

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