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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | A land-surface process/radiobrightness model with coupled heat and moisture transport for fresszing soils显示文摘 | Liou Y A England A W | 1998 | IEEE Transactions on geoscience and remote sensing1998，36，2： | 2 |
| 3 | The organic geochemistry of petroleum reservoirs显示文摘 | | 1990 | Organic Geochemistry1990，16，13： | 1 |
| 4 | The role of the Indone- sian Throughflow on ENSO dynamics in a coupled 'climate model 显示文摘 | Santoso A Cai W England M H | 2011 | Journal of Climate2011，24，： | 1 |
| 5 | Radiobrightness of Diurnal Heated Freezing Soil显示文摘 | England A W | 1990 | IEEE Trans GRS1990，28，： | 1 |
| 6 | A Mantle Plume Origin for the Siberian Traps:Uplift and Extension in the East Siberian Ba- sin, Russia显示文摘 | SAUNDERS A D ENGLAND R W REICHOW M K | 2005 | Lithos2005，79，3： | 1 |
| 7 | Health risk assessment of the migration of unleaded gasoline - a model for petroleum products 显示文摘 | Englande A J | 1992 | Wat Sci Tech1992，25，3： | 1 |
| 8 | Thermal microwave emission from a halfspace con- taining scatterers 显示文摘 | ENGLAND A W | 1974 | Radio Science1974，9，4： | 1 |
| 9 | The rate of pressure dissipation from abnormally pressured compartments显示文摘 | Muggeridge A Abacioglu Y England W | 2005 | AA PG Bulletin2005，89，1： | 1 |
| 10 | The movement and entrapment of petroleum fluids in the subsurface显示文摘 | England W A Mackenzie A S Mann D M | 1987 | Journal ofthe Geological Society1987，144，2： | 1 |
| 11 | Experimental transmission of duck hepatitis B virus显示文摘 | Mason W S Halpern M S England J M | 1983 | Virology1983，131，： | 1 |
| 12 | The movement and entrapment of petroleum fluids in the subsurface 显示文摘 | England W Mackenzie A Mann D | 1987 | Journal of the Ge- ological Society1987，144，2： | 1 |
| 13 | Geochemistry of petroleum reservoirs显示文摘 | England W A Mackenzie A S | 1989 | Geologische Rundschau1989，78，： | 1 |
| 14 | Radiobrightness of diurnally heated,freezing soil显示文摘 | | 1990 | IEEE Trans Geosci Remote Sensing1990，28，： | 1 |
| 15 | A Land-Surface Process/Radiobrightness Model with Couples Heat and Moisture Transport for Freezing Soils显示文摘 | Liou Yuei-An England A W | 1998 | IEEE Transactions on Geoscience and Remote Sensing1998，36，2： | 1 |
| 16 | The movement and entrapment of petroleum fluids in the subsurface 显示文摘 | England W A Mackenzie A S Mann D M | 1987 | J Geol Soc1987，144，： | 1 |
| 17 | Annual temperature and radiobrightness signature for bare soil显示文摘 | England A W | 1996 | IEEE Trans Geosci Remote Sensing1996，34，4： | 1 |
| 18 | Some aspects of the organic geochemistry of petroleum fluid 显示文摘 | England W A Mackenzie A S | 1989 | Geologische Rundschau1989，78，1： | 1 |
| 19 | A model study of the effects of climatic precipitation changes on ground temperatures 显示文摘 | Lin X Smerdon J E England A W | 2003 | Jourlml of Geophysical Research2003，108，7： | 1 |
| 20 | A land surface process/radiobrightness model with coupled heat and moisture transport in soil显示文摘 | England A W | 1998 | IEEE Trans Geosci Remote Sensing1998，36，1： | 1 |
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