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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | New Static Var Compensator Control Strategy and Coordina- tion with Under-load Tap Changer显示文摘 | Flexible AC Transmission Sys- in England by TJ lnternation ABDEL-RAHMAN M H YOUSSEF F M H SABER A A | 2006 | IEEE Transactions on Power Delivery2006，21，3： | 1 |
| 3 | Two-dimen sional simulations of extreme floods on a large watershed显示文摘 | ENGLAND J F VELLEUX M L JULIEN P Y | 2007 | Journal of Hydrology2007，347，： | 1 |
| 4 | TREX:Spa- tially distributed model to assess watershed contaminant transport and fate 显示文摘 | VELLEUX M L ENGLAND J F JULIEN P Y | 2008 | Science of the Total Environment2008，404，： | 1 |
| 5 | A land surface process/radiobrightness model with coupled heat and moisture transport for Prairie grassland显示文摘 | Galantowicz J F England A W | 1999 | IEEE Trans Geosci Remote Sensing1999，37，4： | 1 |
| 6 | Production of clonal plantlets of tropical pine in tissue culture via axillary shoot activation 显示文摘 | Baxter R Brown S N England N F Ludlow C H M Taylor S L Womack R W Dunstan D I | 1989 | Can J Forest Res1989，19，10： | 1 |
| 7 | Economic dimensions of slip and fall injuries显示文摘 | Englander F Hodson TJ Terregrossa RA | 1996 | J Forensic Sci1996，41，5： | 1 |
| 8 | Economic dimensions of slip and fall injuries显示文摘 | Englander F Hodson TJ Terregrossa RA | 1996 | Journal of Forensic Science1996，41，： | 1 |
| 9 | Coincidence correction in red blood cell counting 显示文摘 | LEWIS SM ENGLAND JM KUBOTA F | 1989 | Phys Med Biol1989，34，9： | 1 |
| 10 | Economic dimensions of slip and fall injuries 显示文摘 | Englander F Hodson T J Terregrossa R A | 1996 | Journal of Forensic Sciences1996，41，5： | 1 |
| 11 | Economic dimansions of slip and fall injuries显示文摘 | Hodson TJ Terregrossa RA | 1996 | J Forensic Sci1996，41，5： | 1 |
| 12 | Economic dimensions of slip and fall injuries显示文摘 | Englander F Hodson TJ Terregrossa RA | 1996 | J Forensic Sci1996，41，： | 1 |
| 13 | Integrating Demand-side Management into Utility Planning显示文摘 | Gellings C W Barron W Betley F M England W A Preiss L L Jones DE | 1986 | PowerSystems IEEE Transactions on1986，1，3： | 1 |
| 14 | Comparative efficacy and immunogenicity of Q fever chloroform: Methanol residue (CVM) and phase I cellular (Q-Vax) vaccines in cyanomolgus monkeys challenged by aerosol显示文摘 | Wagg D M England M J Tammariello R F | 2002 | Vaccine2002，20，1920： | 1 |
| 15 | Durability of alkali-sensitive sisal and coconut fibres in cement mortar composites 显示文摘 | Toledo F R D Scrivener K England G L | 2000 | Cement and Concrete Composites2000，22，： | 1 |
| 16 | Classification of the axial collapse of cylindrical tubes under quasi-static loading显示文摘 | ANDREWS K R F ENGLAND G L GHANI E | 1983 | Int J Mech Sci1983，25，910： | 1 |
| 17 | A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture显示文摘 | Van England M Ramaekers F C S Schutte B | 1996 | Cytomtry1996，24，： | 1 |
| 18 | Effect of pressure on the melting and polymorphism of enststite, MgSiO3 显示文摘 | Boyd F R England J L Davis B T C | 1964 | Journal of Geophysical Research1964，69，10： | 1 |
| 19 | The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome显示文摘 | Creed F Fernandes I Guthrie E et aL North of England IBS Research Group | 2003 | Gastroenterology2003，125，5： | 1 |
| 20 | Interaction of light and sterol on sporangium and chlamydospore production by Phytophthora lateralis 显示文摘 | Englander L Roth L F | 1980 | Phytopathology1980，70，5： | 1 |
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