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| 1 | 肥胖、高血压和体力运动决定儿童的血管表型显示文摘心血管病常在儿童时期引发,但是儿童血管健康和疾病的决定因素还不清楚。该研究旨在探讨儿童肥胖、高血压、体能与视网膜微血管健康以及大动脉僵硬度之间的关系。在该横断面研究中,通过标准化的程序来评估1171名小学生[年龄(7.2±0.4)岁]的视网膜中央小动脉直径(central retinal arteriolarequivalent, CRAE)和视网膜中央静脉直径(centralretinal venular equivalent, CRVE)、脉搏波传导速度(pulse wave velocity, PWV)、体质量指数(body massindex,BMI),血压和心肺耐力。 | 陈嘉睿 练桂丽 K?chli S Endes K Steiner R Engler L Infanger D Schmidt-Trucksǎss Zahner L Hanssen H | 2019 | 中华高血压杂志2019，27，4： | 3 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | Substrate compliance ver- sus ligand density in cell on gel responses显示文摘 | Engler A J Bacakova L Newman C | 2004 | Biophys J2004，86，1： | 1 |
| 4 | Matrix elasticity directs stem cell lineage specification 显示文摘 | ENGLER A SEN S SWEENEY H L | 2006 | Cell2006，126，4： | 1 |
| 5 | Extracellular matrix elasticity directs stem cell differentiation 显示文摘 | Engler A J Sweeney H L Discher D E | 2007 | J Musculoskelet Neuronal Interact2007，7，4： | 1 |
| 6 | Autocrine actions of macrophage-derived catecholamines on interleukin-1 beta 显示文摘 | Engler K L Rudd M L Ryan J J | 2005 | J Neuroimmunol2005，160，12： | 1 |
| 7 | Through-process simulation of texture and properties during the thermomechanical processing of aluminium sheets显示文摘 | Engler O Lochte L Hirsch J | 2007 | Acta Materialia2007，55，16： | 1 |
| 8 | Prognostic relevance of coronary collateral function: confounded or causal relationship? 显示文摘 | Seiler C Engler R Berner L | 2013 | Heart2013，99，19： | 1 |
| 9 | Through-process simulation of texture and properties during the thermomechanical propecessing of aluminium sheets 显示文摘 | ENGLER O LOCHTE L HIRSCH J | 2007 | Acta Materialia2007，55，16： | 1 |
| 10 | Monoclonal antibodies to human estrogen receptor显示文摘 | Greene G L Nolan C Engler J P | 1980 | Proc Nad Acad Sci1980，77，： | 1 |
| 11 | Microencapsulation and tissue engineering as an alternative treatment of diabetes显示文摘 | Maria - Engler S S Mares - Guia M Correa M L | 2001 | Braz J Med Biol Res2001，34，6： | 1 |
| 12 | Apoptosis in myocardial ischemia reperfusion显示文摘 | Gottlieb R A Engler R L | 1999 | Ann N Y Acad Sci1999，874，： | 1 |
| 13 | Matrix elasticity directs stem cell lineage specification 显示文摘 | ENGLER A J SEN S SWEENEY H L | 2006 | Cell2006，126，4： | 1 |
| 14 | Leukocyte capillary plugging in myocardialischemia and reperfusion in the dog显示文摘 | ENGLER R L SCHIMD SCHONBEIN G W PAVALEC R S | 1983 | Am J Pathol1983，3，： | 1 |
| 15 | Substrate compliance ver- sus ligand density in cell on gel responses显示文摘 | Engler A Raeakova L Newman C | 2004 | Biophys J2004，86，1： | 1 |
| 16 | Matrix elasticity directs stem cell lineage specification显示文摘 | Engler A J Sen S Sweeney H L | | 0，，04： | 1 |
| 17 | Leukocytecapillary plugging in myocardial ischemia and reperfusion in the dog显示文摘 | Engler R L Schmid-Schonbein G W Pavelec R S | 1983 | Am J Pathol1983，111，1： | 1 |
| 18 | Through-process Simulation of Texture and Properties during the Thermo- mechanical Processing of Aluminium Sheets 显示文摘 | ENGLER O LOCHTE L HIRSCH J | 2007 | Acta Ma- terialia2007，55，： | 1 |
| 19 | Silicone granulomas treated with etanercept 显示文摘 | PASTERNACK F R FOX L P ENGLER D E | 2005 | Arch Dermatol2005，141，1： | 1 |
| 20 | Effects of partially ionised medical oxygen, especially with O^2·-, in vibration white finger patients 显示文摘 | Perecinsky S Murinova L Engler I | 2014 | Int J Environ Res Public Health2014，11，6： | 1 |
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