| 2 | 脉冲染料激光治疗局限性顽固性斑块状银屑病的有效性:一项比较研究显示文摘Background: Localized chronic plaque psoriasis, resistant to local therapy, may be very hard to treat. The treatment of these lesions with a pulsed dye laser (PDL) has been described before, but a comparative study between the PDL and a potent topical treatment has never been performed. Objectives: To compare the efficacy of the PDL in the treatment of localized, recalcitrant plaque psoriasis with a potent topical therapy, using calcipotriol/betamethasone dipropionate (Dovobet ) as an active comparator. Methods: Eight patients with psoriasis were treated with both PDL(585 nm) and calcipotriol/ betamethasone dipropionate in an open, intrapatient, left-right comparison. A plaque severity score (sum score) and photographs were used to document the course of therapy. Patients reported pain on a visual analogue scale. Results: Both treatments were well tolerated, although one patient left the study due to post-PDL treatment pain. A significant difference in the sum score 12 weeks after treatment was seen in favour of the PDL (62% vs. 19% reduction; P < 0.05). Scores for erythema declined significantly at week 12 in both the PDL and the calcipotriol/betamethasone dipropionate group (P < 0.001). Induration and desquamation scores were significantly reduced at week 12 in the PDL group, without a statistically significant reduction in calcipotriol/betamethasone- treated lesions. The pain scores declined with progressive PDL treatments, although not statistically significantly. Conclusions: PDL treatment might be considered for the treatment of localized, recalcitrant plaque psoriasis, when other topical therapies have failed. | Erceg A. Bovenschen H. J. Van De Kerkhof P.C.M. Seyger M. M. B. 李政霄(译) | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，9： | 0 |
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