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| 1 | Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice显示文摘AIM:To evaluate the protective effects on kidney tissue of frequently used intravenous anesthetics(ketamine,propofol,thiopental,and fentanyl)in rats with obstructive jaundice.METHODS:There is an increased incidence of postoperative acute renal failure in patients with obstructive jaundice.Thirty-two Wistar-albino rats were randomly divided into four equal groups.Laparatomy was performed on each animal in the four groups and common bile ducts were ligated and severed on day 0.After 7 d,laparotomy was again performed using ketamine,propofol,thiopental,or fentanyl anesthesia whose antioxidative properties are well known in oxidative stress in a rat liver model of obstructive jaundice.After 2 h,the rats were sacrificed.Renal tissue specimens were analyzed for catalase,superoxide dismutase and malondialdehyde enzymes activities.All values are expressed as the mean±SD.P values less than 0.05 were considered statistically significant.RESULTS:All animals survived without complications until the end of the study.Enlargement in the bile duct and obstructive jaundice were observed in all rats.Catalase was found to be significantly lower in the fentanyl group than in the ketamine(P=0.039),propofol(P=0.012),and thiopental(P=0.001)groups.Superoxide dismutase activities were similar in all groups(P>0.05).Malondialdehyde was found to be significantly lower in the ketamine group than in the propofol(P=0.028),thiopental(P=0.002)and fentanyl(P=0.005)groups.Malondialdehyde was also lower in the fentanyl group than in the thiopental group(P=0.001).The results showed that obstructive jaundice sensitizes renal tissue to damage under the different anesthetics.CONCLUSION:Among the agents tested,ketamine and propofol generated the least amount of oxidative stres on renal tissues in this rat model of obstructive jaundice created by common bile duct ligation.The importance of free radical injury in renal tissue in obstructive jaundice under different intravenous anesthetics during hepatobiliary and liver transplant surgery should be considered for prevention of postoperative acute renal failure. | Sinan Hatipoglu Huseyin Yildiz Ertan Bulbuloglu Ismail Coskuner Ergul Belge Kurutas Filiz Hatipoglu Harun Ciralik Mehmet Sait Berhuni | 2014 | World Journal of Gastroenterology2014，20，12： | 9 |
| 2 | Association of Apolipoprotein E Polymorphisms in Patients with Non-Alcoholic Steatohepatitis显示文摘 | Ali Sazci Gurler Akpinar Cem Aygun Emel Ergul Omer Senturk Sadettin Hulagu | 2008 | Digestive Diseases and Sciences2008，，12： | 3 |
| 3 | Relative attribute based incremental learning for image recognition显示文摘 | Emrah Ergul | 2017 | CAAI Transactions on Intelligence Technology2017，2，1： | 3 |
| 4 | The rs2228570 Variant of the Vitamin D Receptor Gene is Associated with Essential Tremor显示文摘Dear Editor,Essential tremor(ET)is one of the most common movement disorders of unknown etiology[1,2],having an overall prevalence of 4%in the general population[2].The age at onset has been reported to be between 15 years and 20 years,and penetrance to be complete at between50 years and 70 years.It seems to be a progressive neurological disorder,and can lead to substantial disability in some patients.Although it presents some degree of clinical variability,it occurs in sporadic(SET)and familial(FET)forms with heterogeneity of expression between and within families[3].ET is characterized essentially by a postural and kinetic tremor most often affecting the arms,but it can also affect other parts of the body[4].Nonetheless,familial expression of ET has been linked to some loci[5–7]. | Ali Sazci Nihal Uren Halil Atilla Idrisoglu Emel Ergul | 2019 | Neuroscience Bulletin2019，35，2： | 2 |
| 5 | Heredity and familial tendency of acute appendicitis显示文摘 | Ergul E | 2007 | Scand J Surg2007，96，4： | 1 |
| 6 | Extranasopharyngeal angiofibroma of the cheek显示文摘 | Dere H Ozean KM Ergul G | 2006 | J Laryngol Otol2006，120，2： | 1 |
| 7 | Peritoneal adhesions: facing the enemy 显示文摘 | Ergul E Korukluoglu B | 2008 | Int J Surg2008，6，3： | 1 |
| 8 | SSR-based molecular analysis of economically important Turkish apricot cultivars显示文摘 | AKPINAR A E KCK AL H ERGUL A | 2010 | Genetics and Molecular Research2010，9，1： | 1 |
| 9 | Enhancing the accuracy of the interpo lations and anterpolations in MLFMA显示文摘 | Ergul O Gurel L | 2006 | IEEE Transactions on Antennas Propagation2006，54，12： | 1 |
| 10 | Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes:role of endothelin-1显示文摘 | Ergul A Johansen JS Stromhaug C | 2005 | Pharmacol Exp Ther2005，313，： | 1 |
| 11 | Endothelin-1 and diabetic complications: focus on the vasculature显示文摘 | Ergul A | 2011 | Pharmacol Res2011，63，6： | 1 |
| 12 | Lamotrigine-induced SIADH in a child with central diabetes insipidus显示文摘 | Killic H Ekici B Ergul Y | 2011 | J Pediatr Neurosci2011，6，1： | 1 |
| 13 | Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation显示文摘 | ERGUL A PORTIK-DOBOS V GIULUMIAN A D | 2003 | Am J Physiology: Heart Cir Physiol2003，54，： | 1 |
| 14 | Cognitive radio sensor networks显示文摘 | AKAN O B KARLI O B ERGUL O | 2009 | IEEE Networks2009，23，4： | 1 |
| 15 | Prophylactic anti- biotic use in elective inguinal hernioplasty in a trauma center 显示文摘 | ERGUL Z AKINCI M UGURLU C | 2012 | Hernia2012，16，2： | 1 |
| 16 | High-strength lightweight concrete made with scoria aggregate containing mineral admixtures 显示文摘 | ALAETTIN Kilic CENGIZ Duran Atis ERGUL Yasar | 2003 | Cement and Concrete Research2003，33，10： | 1 |
| 17 | Reliability and validaty of the Geriatric Oral Health Assessment Index in Turkey显示文摘 | Ergul S Akar GC | 2008 | J Gerontol Nurs2008，34，： | 1 |
| 18 | Minocycline prevents IL-6 increase after acute ischemic stroke显示文摘 | SwitzerJ A Sikora A Ergul A | 2012 | Transl Stroke Res2012，3，3： | 1 |
| 19 | Downregulation of vascular matrix metalloproteinase inducer and activator proteins in hypertensive patients显示文摘 | ERGUL A PORTIK-DOBOS V HUTCHINSON J | 2004 | Am J Hypertens2004，17，9： | 1 |
| 20 | Perforation of gallbladder显示文摘 | Ergul E Gozetlik EO | 2008 | Bratisl Lek Listy2008，109，5： | 1 |
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