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| 1 | The human TTAGGG repeat factors I and 2 bind to a subsetof interstitial telomeric sequences and satellite repeats显示文摘 | Thomas Simonet Laure-Emmanuelle Zaragosi Claude Philippe Kevin Lebrigand Cldmentine Schouteden Adeline Augereau Serge Bauwens Jing Ye Marco Santagostino Elena Giulotto Frederique Magdinier Beatrice Horard Pascal Barbry Rainer Waldmann Eric Gilson | 2011 | Cell Research2011，21，7： | 7 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | Telomere Lensth Profiles in Humans显示文摘 | Eric Gilson Arturo LV | 2007 | Cell Cycle2007，6，20： | 1 |
| 4 | TRFH domain: at the root of telomere protein evolution?显示文摘 | Marie-Joseph Giraud-Panis Jing Ye Eric Gilson | 2018 | Cell Research2018，28，1： | 1 |
| 5 | Line identification of boron and nitrogen emissions in extreme-and vacuumultraviolet wavelength ranges in the impurity powder dropping experiments of the Large Helical Device and its application to spectroscopic diagnostics显示文摘An impurity powder dropper was installed in the 21 st campaign of the Large Helical Device experiment(Oct.2019–Feb.2020)under a collaboration between the National Institute for Fusion Science and the Princeton Plasma Physics Laboratory for the purposes of real-time wall conditioning and edge plasma control.In order to assess the effective injection of the impurity powders,spectroscopic diagnostics were applied to observe line emission from the injected impurity.Thus,extreme-ultraviolet(EUV)and vacuum-ultraviolet(VUV)emission spectra were analyzed to summarize observable impurity lines with B and BN powder injection.Emission lines released from B and N ions were identified in the EUV wavelength range of 5–300Ameasured using two grazing incidence flat-field EUV spectrometers and in the VUV wavelength range of 300–2400Ameasured using three normal incidence 20 cm VUV spectrometers.BI–BV and NIII–NVII emission lines were identified in the discharges with the B and BN powder injection,respectively.Useful B and N emission lines which have large intensities and are isolated from other lines were successfully identified as follows:BI(1825.89,1826.40)A(blended),BII 1362.46A,BIII(677.00,677.14,677.16)A(blended),BIV 60.31A,BV 48.59A,NIII(989.79,991.51,991.58)A(blended),NIV765.15A,NV(209.27,209.31)A(blended),NVI 1896.80A,and NVII 24.78A.Applications of the line identifications to the advanced spectroscopic diagnostics were demonstrated,such as the vertical profile measurements for the BV and NVII lines using a space-resolved EUV spectrometer and the ion temperature measurement for the BII line using a normal incidence 3 m VUV spectrometer. | 大石鉄太郎 芦川直子 Federico NESPOLI 増崎貴 庄司主 Eric P GILSON Robert LUNSFORD 森田繁 後藤基志 川本靖子 鈴木千尋 孙震 Alex NAGY David A GATES 森崎友宏 | 2021 | Plasma Science and Technology2021，23，8： | 0 |
| 6 | Telomeric impact of conventional chemotherapy显示文摘The increased level of chromosome instability in cancer cells,leading to aneuploidy and gross chromosomal rearrangements,is not only a driving force for oncogenesis but also can be the Achille’s heel of the disease since many chemotherapies(CT)kill cells by inducing a non-tolerable rate of DNA damage.A wealth of published evidence showed that telomere stability can be more affected than the bulk of the genome by several conventional antineoplasic drugs.These results raise the interesting possibility that CT with genotoxic drugs preferentially target telomeres.In agreement with this view,accelerated shortening of telomere length has been described in blood lineage cells following high-dose CT(stem cell transplantation)or non-myeloablative CT.However,almost nothing is known on the consequences of this shortening in terms of telomere stability,senescence and on the development of second cancers or post-treatment aging-like syndromes in cancer survivors(cognitive defect,fertility impairment,etc.).In this article,we propose:(1)telomeres of cancer cells are preferential genomic targets of chemotherapies altering chromosome maintenance;(2)telomere functional parameters can be a surrogate marker of chemotherapy sensitivity and toxicity;(3)the use of anti-telomere molecule could greatly enhance the sensitivity to standards chemotherapies. | Yiming Lu Waiian Leong Olivier Guérin Eric Gilson Jing Ye | 2013 | Frontiers of Medicine2013，7，4： | 0 |
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