|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | 应对全球气候变化:全科医生的临床经验和方法显示文摘背景气候变化是全球公共卫生问题,需要全面深入的思考才能获得行之有效的解决方法。本文从理论上阐述全科医生临床经验和方法对于解决气候变化问题的借鉴意义。讨论我们认为全科医生的经验和特殊思考方式对解决气候变化问题是一笔宝贵的财富。这些财富包括,毕生对'首先不造成伤害'和'处理不确定性'的认知、反思和践行,'面对不完整信息时做出必要决策'的能力,对'复杂自适应系统'的认识,对稳态的维持,对意外后果的警醒,对'跨学科和跨专业'重要性的认识。总结全科医生一直以来都是公共卫生的拥护者。他们对复杂人类问题的处理方式也可用于应对气候变化。 | Grant Blashki Alan Abelsohn Robert Woollard Neil Arya Margot W Parkes Paul Kendal Erica Bell R Warren Bell 邵钧 | 2013 | 中国全科医学2013，16，10： | 2 |
| 4 | Investigating the Antimalarial Action of 1,2 ,4-Trioxolanes with Fluorescent ChemicalProbes显示文摘 | Carmony L H Erica M W L Sumit S M | 2011 | J Med Chem2011，54，23： | 1 |
| 5 | Duffy-null promoter heterozygosity reduces DARC expression and abrogates adhesion of the P. vivax ligand required for blood-stage infection显示文摘 | Pascal Michon Ian Woolley Erica M Wood W Kastens Peter A Zimmerman John H Adams | 2001 | FEBS Letters2001，，1： | 1 |
| 6 | On reconciling the interactions between APETALA2, miR172 and AGAMOUS with the ABC model of flower development 显示文摘 | Heike W Erica M Marco T Jeff A L Detlef W | 2010 | Development2010，137，： | 1 |
| 7 | Advances in the geneticsof endometriosis显示文摘 | Erica CD Robert NT Fritz W | 2010 | Genome Medicine2010，2，： | 1 |
| 8 | Adsorption of Hexadecyltrimethylammonium Bromide to Mica:Nanometer-Scale Study of Binding-Site Competition Effects显示文摘 | William A D Erica J W | 1999 | SPE1999，，： | 1 |
| 9 | The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation显示文摘 | Gloria S Rachalove Erica W | 2004 | MBC2004，15，： | 1 |
| 10 | Enhancing the core scientific meladata model to incorporate derived data显示文摘 | Erica Y Brian M Michael W | 2013 | Future Genera tion Computer Systems2013，29，2： | 1 |
| 11 | A total synthesis prompts the structure revision of haouamine B显示文摘 | Matveenko M Liang G X Erica M W Lauterwasser | 2012 | J Am Chem Soc2012，134，22： | 1 |
| 12 | Previously unsuspected infantile hypertrophic pyloric stenosis diagnosed by endoscopy显示文摘 | Erica W David E John P | | 0，，04： | 1 |
| 13 | Metabolic syndrome: Waist not wants not 显示文摘 | Erica W Lorraine L | 2004 | Canadian Medical Association Journal2004，170，9： | 1 |
| 14 | Metabolic syndrome: Waist not want not显示文摘 | Erica W Lorraine L | 2004 | Canadian Medical Association Journal2004，170，9： | 1 |
| 15 | Previously unsuspected infantile hyper- trophic pyloric stenosis diagnosed by endoscopy 显示文摘 | Erica W David E John P | 2008 | Di - gestive disease and Sciences2008，53，4： | 1 |
| 16 | Measurement of Human Metabolism显示文摘 | Robert B Erica W Jon M | 2010 | IEEE Engineering in Medicine and Biology Magazine2010，7，： | 1 |
| 17 | Avian coronavirus in wild aquatic birds 显示文摘 | Daniel K W Chu Connie Y H Leung Martin O Priscil- la H J Erica M N Tsemay T | 2011 | J Virol2011，85，12： | 1 |
| 18 | Note:a separation principle for a class of assemble-to-order systems with expediting显示文摘 | ERICA L P AMY R W | 2007 | Operation Research2007，55，3： | 1 |
| 19 | Metabolic syndrome: Waist not want not显示文摘 | Erica W Lorraine L | 2004 | Canadian Medical Association Journal2004，170，9： | 1 |
| 20 | Classical Kaposi Sarcoma:Prognostic Factor Analysis of 248 Patients显示文摘 | Baruch B Alina W Erica R | 2002 | Cancer2002，95，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员