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| 1 | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients显示文摘The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense debate.The start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body.This variability seems to be correlated with the presence of genetic polymorphisms.Genotyping is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given gene.However,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that medication.At present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of tacrolimus.However,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and toxicity.For these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing. | Alessio Provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | 加拿大基层医疗改革的创新型及多元化策略显示文摘基层医疗卫生服务体系在世界各国的医疗卫生服务系统中均发挥着重要作用。在过去十年中,加拿大省及地方卫生系统运用了多种方法改善基层医疗卫生服务,改革方案涵盖了目标医疗组织架构、医疗服务者薪酬、医疗服务者数量、医疗服务质量及安全性等方面,改革成果大大提升了家庭医学这个专业实践领域的吸引力,家庭医学吸引了越来越多的医学应届毕业生。这对我国健全基层医疗卫生服务体系具有重要借鉴意义。为此,本刊特别翻译和报道了加拿大基层医疗改革的创新型及多元化策略,敬请关注! | Erin Strumpf Jean-Frédéric Levesque Natalie Coyle Brian Hutchison Marsha Barnes Robert J.Wedel 魏亚萌 | 2015 | 中国全科医学2015，18，31： | 4 |
| 3 | Functional outcomes assessment in shoulder surgery显示文摘The effective evaluation and management of orthopaedic conditions including shoulder disorders relies upon understanding the level of disability created by the disease process. Validated outcome measures are critical to the evaluation process. Traditionally, outcome measures have been physician derived objective evaluations including range of motion and radiologic evaluations. However, these measures can marginalize a patient's perception of their disability or outcome. As a result of these limitations, patient self-reported outcomes measures have become popular over the last quarter century and are currently primary tools to evaluate outcomes of treatment. Patient reported outcomes measures can be general health related quality of life measures, health utility measures, region specific health related quality of life measures or condition specific measures. Several patients self-reported outcomes measures have been developed and validated for evaluating patients with shoulder disorders. Computer adaptive testing will likely play an important role in the arsenal of measures used to evaluate shoulder patients in the future. The purpose of this article is to review the general health related quality-of-life measures as well as the jointspecific and condition specific measures utilized in evaluating patients with shoulder conditions. Advancesin computer adaptive testing as it relates to assessing dysfunction in shoulder conditions will also be reviewed. | James D Wylie James T Beckmann Erin Granger Robert Z Tashjian | 2014 | World Journal of Orthopedics2014，5，5： | 2 |
| 4 | Vitamin D Status and Cardiovascular Health : a 2009 update 显示文摘 | Erin D Michos Jared P Reis Michal L Melamed | 2010 | The Open Clinical Chemistry Journal2010，3，： | 1 |
| 5 | Serum vitamin D,parathyroid hormone levels,and carotid atherosclerosis显示文摘 | Jared P Reis Denise von Muhlen Erin D Michos | | 0，，207： | 1 |
| 6 | Serum vi- tamin D parathyroid hormone levels and carotid atherosclerosis 显示文摘 | Jared P Reis Denise Von Mtlhlen Erin D Michos | 2009 | Atheroselerosis2009，20，7： | 1 |
| 7 | Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation显示文摘 | Jin Cong Shelburne Christopher P Li Guojie Potts Erin N Riebe Kristina J Sempowski Gregory D Foster W Michael Abraham Soman N | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 8 | Vein wall re - endo- thelialization after deep vein thrombosis is improved with low - mo- lecular-weight heparin显示文摘 | DARIA K MOAVENI M D ERIN M | 2008 | J Vasc Surg2008，47，3： | 1 |
| 9 | Phosphate transport and senesing in Saccharomyces cerevisiae显示文摘 | DENNIS D W ERIN K O | 2001 | Genetics2001，159，： | 1 |
| 10 | A comparison of human immunodeficiency virus,hepatitis C virus,hepatitis B virus,and human Tlymphotropic virus marker rates for directed versus volunteer blood donations to the American Red Cross during 2005 to 2010显示文摘 | Kerri A Erin D Whitney R | | 0，，6： | 1 |
| 11 | Maternal diabetes mellitus and infant malformations显示文摘 | Jeanne S Sheffield MD Erin L Butler-Koster MD Brian M Casey MD Donald D McIntire PhD Kenneth J Leveno MD | 2002 | Obstetrics & Gynecology2002，100，： | 1 |
| 12 | Should Cruise Ports Market Ecotourism? A Comparative Analysis of Passenger Spending Expecta- tions within the Panama Canal Watershed显示文摘 | Brooke Thuran Erin Seekamp Andrew D Carver | 2015 | International Journal of Tourism Research2015，17，1： | 1 |
| 13 | Consequences of Indibidual' Fit at Work:a Meta-Analusis of Person-Job显示文摘 | Amy L Kristof-Brown Ryan D Zimmerman Erin C Johnson 2005 | 2005 | Personnel Psychology2005，58，2： | 1 |
| 14 | Adenosine and pediatric supraventricular tachycardia in the emergency department:muhicenter study and review显示文摘 | Joseph D losek Erin Endom Ann Dietrich | 1999 | Annals of Emergency Medcine1999，2，： | 1 |
| 15 | Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease显示文摘AIM To determine the sensitivity of macroscopic appearance for predicting histological diagnosis at sites other than duodenum in pediatric celiac disease(CD).METHODS Endoscopic and histologic findings in pediatric patients undergoing upper endoscopy for first-time diagnosis of CD at Stollery Children's Hospital from 2010-2012 were retrospectively reviewed.RESULTS Clinical charts from 140 patients were reviewed. Esophageal and gastric biopsies were taken in 54.3% and 77.9% of patients, respectively. Endoscopic appearance was normal in the esophagus and stomach in 75% and 86.2%. Endoscopic esophageal diagnoses were eosinophilic esophagitis(EE)(11.8%), esophagitis(7.9%), glycogenic acanthosis(1.3%) and non-specific abnormalities(3.9%). Endoscopic gastric diagnoses were gastritis(8.3%), pancreatic rest(0.9%), and nonspecific abnormalities(4.6%). Histology was normal in 76.3% of esophageal and 87.2% of gastric speci-mens. Abnormal esophageal histology was EE(10.5%), esophagitis(10.5%), glycogenic acanthosis(1.3%) and non-specific(1.3%). Gastritis was reported in 12.8% of specimens. Sensitivity and specificity of normal endoscopy for predicting normal esophageal histology was 86.2% and 61.1%, and for normal gastric histology was 87.4% and 21.4%.CONCLUSION In the absence of macroscopic abnormalities, routine esophageal and gastric biopsy during endoscopy for pediatric CD does not identify major pathologies. These findings have cost and time saving implications for clinical practice. | Erin D Boschee Jason YK Yap Justine M Turner | 2017 | World Journal of Gastroenterology2017，23，4： | 1 |
| 16 | Archaeol as a methanogen biomarker in ombrotrophic bogs 显示文摘 | Richard D Pancost Erin L Mclymont B | 2011 | Organic Geochemistry2011，，42： | 1 |
| 17 | Effects of biomaterial surface chemistry on the adhesion and bio- film formation of Staphylococcus epidermidis in vitro 显示文摘 | Erin E MacKintosh Jasmine D Patel Roger E Mar'chant | 2006 | J Bi- omed Mater Res A2006，78，4： | 1 |
| 18 | Further evidence for a role of tumor CD200 expression in breast cancer metastasis:decreased metastasis in CD200R1KO mice or using CD200-silenced EMT6显示文摘 | Podnos A Clark D A Erin N | 2012 | Breast Cancer Res Treat2012，136，11： | 1 |
| 19 | Assessment of diversity in Claviceps africana and other Claviceps species by RAM and AFLP analyses 显示文摘 | Paul W T Nichole R O' Neill Erin D G | 2000 | Phytopathology2000，90，10： | 1 |
| 20 | Ten species in one: DNA barcoding reveals cryptic species in the neotropical skipper butterfly Astraptes fulgerator显示文摘 | Hebert Paul D N Penton Erin H Burns John M Janzen Daniel M Hallwachs Winnie | 2004 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA2004，101，14： | 1 |
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