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| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Predictive value of C-reactive protein/albumin ratio in acute pancreatitis显示文摘BACKGROUND:Serum C-reactive protein(CRP) increases and albumin decreases in patients with inflammation and infection.However,their role in patients with acute pancreatitis is not clear.The present study was to investigate the predictive significance of the CRP/albumin ratio for the prognosis and mortality in acute pancreatitis patients.METHODS:This study was performed retrospectively with 192 acute pancreatitis patients between January 2002 and June 2015.Ranson scores,Atlanta classification and CRP/albumin ratios of the patients were calculated.RESULTS:The CRP/albumin ratio was higher in deceased patients compared to survivors.The CRP/albumin ratio was positively correlated with Ranson score and Atlanta classification in particular and with important prognostic markers such as hospitalization time,CRP and erythrocyte sedimentation rate.In addition to the CRP/albumin ratio,necrotizing pancreatitis type,moderately severe and severe Atlanta classification,and total Ranson score were independent risk factors of mortality.It was found that an increase of 1 unit in the CRP/albumin ratio resulted in an increase of 1.52 times in mortality risk.A prediction value about CRP/albumin ratio >16.28 was found to be a significant marker in predicting mortality with 92.1% sensitivity and 58.0% specificity.It was seen that Ranson and Atlanta classification were higher in patients with CRP/albumin ratio >16.28 compared with those with CRP/albumin ratio ≤16.28.Patients with CRP/albumin ratio >16.28 had a 19.3 times higher chance of death.CONCLUSION:The CRP/albumin ratio is a novel but promising,easy-to-measure,repeatable,non-invasive inflammationbased prognostic score in acute pancreatitis. | Mustafa Kaplan Ihsan Ates Muhammed Yener Akpinar Mahmut Yuksel Ufuk Baris Kuzu Sabite Kacar Orhan Coskun Ertugrul Kayacetin | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 53 |
| 3 | Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease显示文摘A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully understood.In the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in hepatocytes.Because of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed models.Although these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease. | Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin Orhan Tarcin Abdullah Sonsuz | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
| 4 | Three-dimensional MR and axial CT colonography versus conventional colonoscopy for detection of colon pathologies显示文摘瞄准:在检测冒号损害评估先生 colonography (MRC ) 和 CT 性能的敏感和特性,并且把他们的敏感和特性与常规结肠镜检查的作比较。方法:怀疑有结肠的损害的 42 个病人因为直肠的流血,积极烘便的潜血测试结果或改变的肠习惯,经历了考试。在一个直肠的试管的插入以后,冒号充满 9 g/L NaCl 答案, 0.5 mmol/L gadopentetate dimeglumine 的 15-20 mL 和 iodinized 对比材料的 100 mL 的混合物的 1000-1500 mL。为先生 colonography 和互补先生图象的从前结肠的扩张被完成的、三维的坡度回响(3D-GRE ) 序列在所有情况中被拿。立即在先生 colonography 以后,腹的 CT 图象被螺线 CT 拿在里面轴并且背卧位。然后,所有病人被常规结肠镜检查(CC ) 检查。结果:为冒号病理的 MRC 的敏感和特性是 96.4% 并且 100% 分别地。由 MRC 的正确诊断的百分比是 97.6% 。百分之百,为冒号病理的 CT 的敏感和特性分别地是 92.8% 。由 CT 的正确诊断的百分比是 95.2% 。结论:在检测冒号损害, MRC 完成了类似于 CC 的诊断精确性。然而, MRC 是最低限度地侵略的,没有对在调查期间的镇静或止痛剂的需要。有穿孔风险的一个更低的百分比,并且所有冒号片断能由于多部分的成像可获得性被评估;结肠的损害,转移和任何另外的损害的内部、额外肠的部件能容易被评估。MRC 和 CT colonography 是答应在颜色的察觉高度敏感的新放射学的技术表面的集体、煽动性的肠损害。 | Rahime Haykir Serdar Karakose Aydin Karabacakoglu Mustafa Sahin Ertugrul Kayacetin | 2006 | World Journal of Gastroenterology2006，12，15： | 12 |
| 5 | Interesting rendezvous location in a liver transplantation patient with anastomosis stricture显示文摘An endoscopic or radiologic percutaneous approach may be an initial minimally invasive method for treating biliary strictures after living donor liver transplantation; however, cannulation of biliary strictures is sometimes difficult due to the presence of a sharp or twisted angle within the stricture or a complete stricture. When an angulated or twisted biliary stricture interrupts passage of a guidewire over the stricture, it is difficult to replace the percutaneous biliary drainage catheter with inside stents by endoscopic retrograde cholangiopancreatography. The rendezvous technique can be used to overcome this difficulty. In addition to the classical rendezvous method, in cases with complete transection of the common bile duct a modified technique involving the insertion of a snare into the subhepatic space has been successfully performed. Herein, we report a modified rendezvous technique in the duodenal bulb as an extraordinary location for a patient with duct-to-duct anastomotic complete stricture after liver transplantation. | Bulent Odemis Erkin Oztas Mehmet Yurdakul Serkan Torun Nuredtin Suna Ertugrul Kayacetin | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 6 | Gastric ulcer penetrating to liver diagnosed by endoscopic biopsy显示文摘Liver Penetration is a rare but serious complication of piptic ulcer diserase. Usually the diahnosis is made by operation or artopsy. Clinical and laboratory data were no specific. A 64-year-old man was admitted with upper gastrointestinal bleeding .Hepatic penetration was diagnosed as the cause of bleeding. Endosciopy showed a large gastric with a pseudotumoral mass protruding from the ulcer bed. Definitive diagnosis was established by endoscopic biopsies of the ulcer base. | Ertugrul Kayacetin Serra Kayacetin | 2004 | World Journal of Gastroenterology2004，10，12： | 2 |
| 7 | Portal and splenic hemodynamics in cirrhotic patients: relationship between esophageal variceal bleeding and the severity of hepatic failure显示文摘 | Ertugrul Kayacetin Duran Efe Cengiz Do?an | 2004 | Journal of Gastroenterology2004，，7： | 1 |
| 8 | Alverine citrate induced acute hepatitis显示文摘Alverine citrate is a commonly used smooth muscle relaxant agent. A MEDLINE search on January 2004 revealed only 1 report implicating the hepatotoxicity of this agent. A 34- year-old woman was investigated because of the finding of elevated liver function tests on biochemical screening. Other etiologies of hepatitis were appropriately ruled out and elevated enzymes were ascribed to alverine citrate treatment.Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case, several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity. | Mehmet Arhan Seyfettin Kklü Aydln S Kksal mer F Yoicu Senem Koruk Irfan Koruk Ertugrul Kayacetin | 2004 | World Journal of Gastroenterology2004，10，15： | 1 |
| 9 | Helicobacter pylori infection in patients with autoimmune thrombocytopenic purpura显示文摘AIM: To compare the prevalence of Helicobacter pylori(Hpylori) infection in autoimmune thrombocytopenic purpura (AITP) patients with that of nonthrombocytopenic controls,and to evaluate the efficacy of the treatment in Hpylori(+)and Hpylori(-) AITP patients.METHODS: The prevalence of gastric Hpyloriinfection in 38 adult AITP patients (29 female and 9 male; median age 27 years; range 18-39 years) who consecutively admitted to our clinic was investagated.RESULTS: Hpyloriinfection was found in 26 of 38 AITP patients (68.5%). Hpyloriinfection was found in 15 of 23 control subjects (65.2%). The difference in Hpyloriinfection between the 2 groups was not significant. Thrombocyte count of Hpylori-positive AITP patients was significantly lower than that of Hpylori-negative AITP patients (P<0.05).Thrombocyte recovery of Hpylori-positive group was less than that of Hpylori-negative group (P<0.05).CONCLUSION: Hpyloriinfection should be considerecd in the treatment of AITP patients with Hpyloriinfection. | Erdal Kurtoglu Ertugrul Kayacetin Aysegul Ugur | 2004 | World Journal of Gastroenterology2004，10，14： | 1 |
| 10 | Mesenteric Ischemia:An unusual presentation of fistula between superior mesenteric artery and common hepatic artery显示文摘Chronic mesenteric ischemia is an uncommon condition associated with a high morbidity and mortality. We reported a 36-year old women with postprandial abdominal pain due to chronic mesenteric ischemia caused by a fistula between superior mesenteric arid common hepatic artery. | Ertugrul Kayacetin Serdar Karakse Aydin Karabacakoglu Dilek Emlik | 2004 | World Journal of Gastroenterology2004，10，17： | 1 |
| 11 | Ankaferd hemostat in the management of gastrointestinal hemorrhages显示文摘Gastrointestinal (GI) bleeding refers to any hemorrhage ascribed to the pathologies of the gastrointestinal tract,extending from the mouth to the anal canal.Despite the recent improvements in the endoscopic,hemostatic and adjuvant pharmacologic techniques,the reported mortality is still around 5%-10% for peptic ulcer bleeding and about 15%-20% for variceal hemorrhages.Although endoscopic management reduces the rates of re-bleeding,surgery,and mortality in active bleeding;early recurrence ratios still occur in around 20% of the cases even with effective initial hemostatic measures.In this quest for an alternative pro-hemostatic agent for the management of GI bleedings,Ankaferd blood stopper (ABS) offers a successful candidate,specifically for 'difficult-to-manage' situations as evidenced by data presented in several studies.ABS is a standardized mixture of the plants Thymus vulgaris,Glycyrrhiza glabra,Vitis vinifera,Alpinia officinarum,and Urtica dioica.It is effective in both bleeding individuals with normal hemostatic parameters and in patients with deficient primary and/or secondary hemostasis.ABS also modulates the cellular apoptotic responses to hemorrhagic stress,as well as hemostatic hemodynamic activity.Through its effects on the endothelium,blood cells,angiogenesis,cellular proliferation,vascular dynamics,and wound healing,ABS is now becoming an effective alternative hemostatic medicine for gastrointestinal bleedings that are resistant to conventional anti-hemorrhagic measurements.The aim of this review is to outline current literature experience suggesting the place of ABS in the management of GI bleeding,and potential future controlled trials in this complicated field. | Yavuz Beyazit Murat Kekilli Ibrahim C Haznedaroglu Ertugrul Kayacetin Metin Basaranoglu | 2011 | World Journal of Gastroenterology2011，17，35： | 1 |
| 12 | Mangafodipir trisodium-enhanced magnetic resonance imaging for evaluation of pancreatic mass and mass-like lesions显示文摘瞄准:由在造影剂注射以后评估损害和胰腺的实质的对比举起特征在焦点的胰腺的群众和像团的损害中调查 mangafodipir trisodium (MnDPDP ) 的角色。方法:有胰腺的集体或像团的损害的 37 个病人的一个总数被 unenhanced 和提高 MnDPDP 的磁性的回声成像(MRI ) 检验。结果:在 MnDPDP 和同类的对比改进的注入在正常的胰实质被观察以后, MRI 是获得的 20-40 min。在有衰退的胰的病人,在提高 MnDPDP 的 MRI 上的胰腺的实质没有改进。在有 41 胰腺的群众和像团的损害的 37 个病人,对比改进在 MnDPDP 上在 5 损害被观察提高的 MRI。这 5 损害中的三个是焦点的胰腺炎和其它 2 是腺癌。没有对比改进在 32 个病人在 36 胰腺的群众和像团的损害中被决定。结论:特别在没有实质萎缩的情况中, MnDPDP 提高对比的 MRI 能区分焦点的胰腺的损害边缘。胰腺的实质的功能的信息能从肿瘤被获得。MnDPDP 在肝由变形损害的察觉便于胰腺的肿瘤的阶段。另外,减少了在有胰腺炎的病人的 MnDPDP 的 heteregenous 举起可能在鉴别诊断是有用的。 | Gul Eser Aydin Karabacakoglu Serdar Karakose Cengiz Eser Ertugrul Kayacetin | 2006 | World Journal of Gastroenterology2006，12，10： | 0 |
| 13 | Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis:Single shot for two targets显示文摘Coexistence of Crohn's disease(CD) and familial Mediterranean fever(FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD. | Mahmut Yuksel Fatih Saygili Orhan Coskun Nuretdin Suna Mustafa Kaplan Ufuk Baris Kuzu Zeki Mesut Yalin Kilic Yasemin Ozderin Ozin Ertugrul Kayacetin | 2015 | World Journal of Gastroenterology2015，21，13： | 0 |
| 14 | Thiol/disulphide homeostasis in celiac disease显示文摘AIM To determine dynamic thiol/disulphide homeostasis in celiac disease and to examine the associate with celiac autoantibodies and gluten-free diet.METHODS Seventy three patients with celiac disease and 73 healthy volunteers were enrolled in the study. In both groups, thiol/disulphide homeostasis was examined with a new colorimetric method recently developed by Erel and Neselioglu. RESULTS In patients with celiac disease, native thiol(P = 0.027) and total thiol(P = 0.031) levels were lower, while disulphide(P < 0.001) level, disulphide/native thiol(P < 0.001) and disulphide/total thiol(P < 0.001) ratios were higher compared to the control group. In patients who do not comply with a gluten-free diet, disulphide/native thiol ratio was found higher compared to the patients who comply with the diet(P < 0.001). In patients withany autoantibody-positive, disulphide/native thiol ratio was observed higher compared to the patients with autoantibody-negative(P < 0.05). It is found that there is a negative correlation between celiac autoantibodies, and native thiol, total thiol levels and native thiol/total thiol ratio, while a positive correlation is observed between disulphide, disulphide/native thiol and disulphide/total thiol levels.CONCLUSION This study is first in the literature which found that the patients with celiac disease the dynamic thiol/disulphide balance shifts through disulphide form compared to the control group. | Mustafa Kaplan Ihsan Ates Mahmut Yuksel Yasemin Ozderin Ozin Murat Alisik Ozcan Erel Ertugrul Kayacetin | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，2： | 0 |
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