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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | On Strong Distance in Strong Oriented Graphs显示文摘 | Chartrand G Erwin D Raines M Zhang P | 1999 | Congr Numer1999，138，： | 1 |
| 5 | The end and the beginning: recoveries from mass extinction显示文摘 | Erwin D H | 1998 | Trends in Ecology and Evolution1998，13，： | 1 |
| 6 | Radio labelings of graphs显示文摘 | CHARTRAND G ERWIN D HARARY F | 2001 | Bull Inst Combin AppL2001，33，： | 1 |
| 7 | Inventory control in hybrid systems with remanufaeturing显示文摘 | ERWIN V D MARCM L S ROMMET D | 1999 | Management Science1999，145，5： | 1 |
| 8 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction 显示文摘 | Bowring S A Erwin D H Jin Y | 1998 | Science1998，280，： | 1 |
| 9 | A graph labeling problem suggested by FM channel restHctions显示文摘 | CHARTRAND G ERWIN D ZHANG P | 2005 | Bull Inst Combin Appl-2005，43，： | 1 |
| 10 | Fossils, molecules and embryos: new perspectives on the Cambrian explosion显示文摘 | Valentine JW Joblonski D Erwin DH | 1999 | Development1999，126，： | 1 |
| 11 | Evaluation of success rate and access time for an adult sternal intraosseous device deployed in the prehospital setting 显示文摘 | Byars D V Tsuchitani S N Erwin E | 2011 | Prehosp Disaster Med2011，26，2： | 1 |
| 12 | Candida albicans drug resistance-another way to cope with stress显示文摘 | Richard D C Erwin L Ann R H | 2007 | Microbiology2007，153，10： | 1 |
| 13 | Effectiveness of school- based mental health services for children: A 10 -year research re- view显示文摘 | Hoagwood K Erwin H D | 1997 | Journal of Child and Family Studies1997，6，4： | 1 |
| 14 | Non equilibrium molecular motion in a hypersonic shock wave显示文摘 | PHAM-Van DIEP G ERWIN D MUNTZ E P | | 0，，4918： | 1 |
| 15 | Epidermal growth factor is critical for intestinal adaptation following small bowel resection 显示文摘 | Stem L E Erwin C R O'Brien D P | 2000 | Microsc Res Tech2000，51，2： | 1 |
| 16 | Autecol- ogy and the filling of ecospace: key metazoan radia- tions 显示文摘 | BAMBACH R K BUSH A M ERWIN D H | 2007 | Palaeontology2007，50，： | 1 |
| 17 | Inhibition of heparanase activity and heparanase - induced angiogenesis by suramin analogues显示文摘 | Marchetti D Reiland J Erwin B | 2003 | Int J Cancer2003，104，2： | 1 |
| 18 | The Permo-Triassic extinction显示文摘 | Erwin D H | 1994 | Nature1994，367，： | 1 |
| 19 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 20 | A group-IV ferromagnetic semiconductor : Mnx Ge1-x 显示文摘 | PARK Y D HANBICKI A T ERWIN S C | 2002 | Science2002，295，5555： | 1 |
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