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| 1 | Pharmacogenomics in colorectal cancer: The first step for individualized-therapy显示文摘Interindividual differences in the toxicity and response to anticancer therapies are currently observed in practically all available treatment regimens. A goal of cancer therapy is to predict patient response and toxicity to drugs in order to facilitate the individualization of patient treatment. Identification of subgroups of patients that differ in their prognosis and response to treatment could help to identify the best available drug therapy according the genetic profile. Several mechanisms have been suggested to contribute to chemo-therapeutic drug resistance: amplification or overexpression of membrane transporters, changes in cellular proteins involved in detoxification or in DNA repair, apoptosis and activation of oncogenes or tumor suppressor genes. Colorectal cancer (CRC) is regarded as intrinsically resistant to chemotherapy. Several molecular markers predictive of CRC therapy have been included during the last decade but their results in different studies complicate their application in practical clinical. The simultaneous testing of multiple markers predictive of response could help to identify more accurately the true role of these polymorphisms in CRC therapy. This review analyzes the role of genetic variants in genes involved in the action mechanisms of the drugs used at present in colorectal cancer. | Eva Bandrés Ruth Zárate Natalia Ramirez Ana Abajo Nerea Bitarte Jesus García-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Moving forward in colorectal cancer research, what proteomics has to tell显示文摘Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer. | Nerea Bitarte Eva Bandrés Ruth Zárate Natalia Ramirez Jesus Garcia-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 3 | Resveratrol attenuates lipopolysaccharide-induced hepatitis in d -galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1显示文摘 | Hassan Farghali Dalibor ?erny Ludmila Kameníková Jind?ich Martínek Ale? Ho?ínek Eva Kmoní?ková Zdeněk Zídek | 2009 | Nitric Oxide2009，，3： | 2 |
| 4 | Long-term variability and methods of forecasting dates of ice break-up in the mouth area of the Ob and Yenisei rivers显示文摘 | Shevnina E V Solov' eva Z S | 2008 | Russian Meteorology and Hydrology2008，33，7： | 1 |
| 5 | Hippocampal changes in patients with a first episode of major deprersion显示文摘 | Eva MM Thomas Z | 2002 | Am J Psychiatry2002，159，7： | 1 |
| 6 | Transgenic mouse model for estrogen-regulated lipoprotein metabolism:studies on apoVLDL-Ⅱ expression in transgenic mice显示文摘 | EVA Z MELINDA K N FRANCA E | 1995 | J Lipid Res1995，36，7： | 1 |
| 7 | Multifractal Detrended Fluctuation Analysis of Nonstationary Time Serics显示文摘 | Kantelhardt J W Stephan A Z Eva K B | 2002 | Physics A2002，316，： | 1 |
| 8 | Brain electrical source imaging in manic and depressive episodes of bipolar disorder显示文摘 | Annamaria Painold Pascal L Faber Patricia Milz Eva Z Reininghaus Anna K Holl Martin Letmaier Roberto D Pascual‐Marqui Bernd Reininghaus Hans‐Peter Kapfhammer Dietrich Lehmann | 2014 | Bipolar Disord2014，，7： | 1 |
| 9 | Vitamin D deficiency in undifferentiated connective tissue disease显示文摘 | Eva Z Peter S Janos G | 2008 | Arthritis Researh & Therapy2008，10，5： | 1 |
| 10 | Hippocampal changes in patients with a first episode of major deprersion 显示文摘 | Thomas F Eva MM Thomas Z | 2002 | Am J Psychiatry2002，159，： | 1 |
| 11 | Novel method for localization of common carotid artery transverse section in ultrasound images using modified Viola-Jones detector显示文摘 | Kamil ?íha Jan Ma?ek Radim Burget Radek Bene? Eva Závodná | 2013 | Ultrasound in Medicine & Biology2013，，： | 1 |
| 12 | Multifractal detrended fluctuation analysis of nonstationary time series显示文摘 | Kantelhardt J W Stephan A Z Eva K B | 2002 | Physics A2002，316，： | 1 |
| 13 | Long-term variability and methods of forecasting dates of ice break-up in the mouth area of the Ob and Yenisei rivers显示文摘 | SHEVNINA E V SOLOV'EVA Z S | 2008 | Russian Meteorology and Hydrology2008，33，7： | 1 |
| 14 | Hippoeampal changes in patients with a first episode of major depression显示文摘 | Thomas F Eva MM Thomas Z | 2002 | Am J Psychiatry2002，159，7： | 1 |
| 15 | Multifractal Detrended Fluctuation Analysis of Nonstationary Time Series 显示文摘 | Kantelhardt J W Stephan A Z Eva K B | 2002 | Physics A2002，316，： | 1 |
| 16 | Quantum interference between two single photons of different microwave frequencies 显示文摘 | Francois N Eva Z B Raymond W | 2011 | Mesoscale and Nanoscale Physics2011，12，8： | 1 |
| 17 | Psychological impact of the COVID-19 pandemic on individuals with serious mental disorders: A systematic review of the literature显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic is having a great impact on individuals from all over the world,particularly on individuals with mental disorders.Several studies found more pronounced psychiatric symptoms,notably symptoms of depression and anxiety.AIM To assess the situation of patients with serious mental illness(SMI:Affective disorders and schizophrenia)regarding their mental health outcome during the pandemic.METHODS A systematic search using the databases PubMed and MEDLINE was conducted,employing the key words“COVID-19”,“SARS-CoV-2”,“psychiatric/mental disorder/illness”,“affective/mood disorder”,“bipolar disorder”,“(major)depression”,“schizoaffective disorder”,and“schizophrenia”.Studies that had been published up until January 9,2021 were included.Information of studies in languages other than English and German was mostly taken from their English abstracts.RESULTS The literature search concluded in the finding of 36 studies containing relevant clinical data.A general impairment of the mental health of individuals with SMI could be detected,particularly in individuals with affective disorders,as compared to those with schizophrenia.Compared to healthy controls,symptoms of anxiety,depression,and stress were more pronounced in individuals with SMI.Relevant factors found that impacted their mental health were age,resilience,and socioeconomic environment,especially the shortage of mental health services,lack of social support,and inadequate information about COVID-19.CONCLUSION In light of these results,mental health services should be reinforced,notably the use of telemental health services.Furthermore,supplying individuals with SMI with adequate information about the COVID-19 pandemic and increasing their resilience is important.When researching the impact of the COVID-19 pandemic on individuals with SMI,standardization as well as follow-up studies are needed to enable better comparability and understanding. | Eva Fleischmann Nina Dalkner Frederike T Fellendorf Eva Z Reininghaus | 2021 | World Journal of Psychiatry2021，11，12： | 1 |
| 18 | Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane an chored TNF显示文摘 | MATTHIAS G GUDRUN Z EVA G | 1999 | EMBOJ1999，18，11： | 1 |
| 19 | Qualitative and quantitative analysis of aconitine-type and lipo-alkaloids of Aconitum carmichaelii roots 显示文摘 | Dczs(i C Eva M W Istvdn Z | 2009 | J Chromatogra A2009，1215，11： | 1 |
| 20 | p21-activated kinase 4 interacts with integrin αvβ 5 and regulates αvβ5-mediated cell migration显示文摘 | Hongquan Z Zhilun L Eva - Karin V | 2002 | J Cell biol2002，158，7： | 1 |
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