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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Relation of neuroendocrine cells to transforming growth factor-alpha and epidermal growth factor receptor expression in gastric adenocarcinomas : prognostic implications 显示文摘 | Celikel C Eren F Gulluoglu B | 2007 | Pathol Oncol Res2007，13，3： | 1 |
| 3 | Additive prognostic value of NT-proBNP over TIMI risk score in intermediate-risk patients with acute coronary syndrome显示文摘 | Eren NK Ertas F Yflksek U | | 0，，01： | 1 |
| 4 | Experiments with tuned absorber-impact damper combination 显示文摘 | Eren Semercigil S Collette F Huynh D | 2002 | Journal of Sound and Vibration2002，256，1： | 1 |
| 5 | Serum progranulin as an independent marker of liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease显示文摘 | Yilmaz Y Eren F Yonal O | 2011 | Dis Markers2011，31，4： | 1 |
| 6 | BCL-2 and P53 expression in endometrial carcinoma显示文摘 | Erkanli S Eren F Pekin S Bagis T | 2004 | Exp Clin Cancer Res2004，23，1： | 1 |
| 7 | Diaphragmatic hernia: diagnostic approaches with review of the literature 显示文摘 | Eren S Ciris F | 2005 | Eur J Radiol2005，54，3： | 1 |
| 8 | Serum levels of vaspin, obesta- tin, and apelin - 36 in patients with nonalcoholic fatty liver disease 显示文摘 | Aktas B Yilmaz Y Eren F | 2011 | Metabolism2011，60，4： | 1 |
| 9 | Serum osteocalcin levels in patients with nonalcoholic fatty liver disease: association with ballooning degeneration显示文摘 | Yilmaz Y Kurt R Eren F | 2011 | Scand J Clin Lab Invest2011，71，8： | 1 |
| 10 | Architectures for product families 显示文摘 | Erens F Verhulst K | 1997 | Computers in Industry1997，33，2： | 1 |
| 11 | Local delivery of chitosan/ VEGF siRNA nanoplexes reduces angiogenesis and growth of breast cancer in vivo 显示文摘 | Salva E Kabasakal L Eren F | 2012 | Nucleic acid therapeutics2012，22，1： | 1 |
| 12 | Neuroendocrine differentiation in gastric adenocarcinomas;correlation with tumor stage and expres- sion of VEGF and p53 显示文摘 | Eren F Celikel C Gulltiolu B | 2004 | Pathol Oncol Res2004，10，1： | 1 |
| 13 | Optimization of osmotic dehydration of potato using response surface methodology 显示文摘 | Eren I Kaymak-Ertekin F | 2007 | Journal of Food Engineering2007，79，1： | 1 |
| 14 | Serum osteocalcin levels in patients with nonalcoholic fatty liver disease:association with ballooning degeneration显示文摘 | Yilmaz Y Kurt R Eren F | 2011 | Scand J Clin Lab Invest2011，71，： | 1 |
| 15 | Architecture for Product Families显示文摘 | Verhulst K | 1997 | Computer in Industry1997，33，2： | 1 |
| 16 | Removal of Cu ( Ⅱ ) ions by activated poplar sawdust ( Samsun Clone) from aqueous solutions 显示文摘 | Acar F N Eren Z | 2006 | Journal of Hazardous Materials2006，137，： | 1 |
| 17 | Serum levels of vaspin, obestatin, and apelin-36 in patients with nonalcoholic fatty liver disease显示文摘 | Aktas B Yilmaz Y Eren F | 2011 | Metabolism2011，60，4： | 1 |
| 18 | Architectures for Product Families显示文摘 | Erens F Verhulst K | 1997 | Computers in Industry1997，33，23： | 1 |
| 19 | Optimization of osmotic dehydration of potato using response surface methodology显示文摘 | Eren I Kaymak-Ertekin F | 2007 | Journal of Food Engineering2007，79，1： | 1 |
| 20 | Architectures for product families显示文摘 | Erens F Verhulst K | 1997 | Computers in Industry1997，33，2： | 1 |
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