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| 1 | Interferon-α response in chronic hepatitis B-transfected HepG2.2.15 cells is partially restored by lamivudine treatment显示文摘AIM: To characterize the IFN-response and its modul- ation by the antiviral compound lamivudine in HBV- transfected HepG2.2.15 cells. METHODS: HepG2.2.15 and HepG2 cells were stimulated with various concentrations of IFN-a2a in the presence or absence of lamivudine. Then, total RNA was extracted and analysed by customised cDNA arrays and northern blot for interferon-inducible genes (ISGs). In addition, cellular proteins were extracted for EMSA and western blot. HBV replication was assessed by southern blot or ELISAs for HBsAg and HBeAg. RESULTS: Two genes (MxA, Cig5) with completely abolished and 4 genes (IFITM1, -2, -3, and 6-16) with partially reduced IFN-responses were identified in HepG2.2.15 cells. In 2 genes (IFITM1, 6-16), the response to IFN-a could be restored by treatment with lamivudine. This effect could not be explained by a direct modulation of the Jak/Stat signalling pathway since EMSA and western blot experiments revealed no suppression of Stat1 activation and ISGF3 formation after stimulation with IFN-a in HepG2.2.15 compared to HepG2 cells. CONCLUSION: These results are consistent with the assumption that chronic hepatitis B may specifically modulate the cellular response to IFN by a selective blockage of some ISGs. Antiviral treatment with lamivudine may partially restore ISG expression by reducing HBV gene expression and replication. | Shi-He Guan Mengji Lu Petra Grünewald Michael Roggendorf Guido Gerken Joerg F Schlaak | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Leber's hereditary optic neuropathy is associated with the mitochondrial ND4 G11696A mutation in five Chinese families显示文摘 | Zhou XT Wei QP Yang L Tong Y Zhao FX Lu CJ Qian YP Sun YH Lu F Qu J Guan MX | 2006 | 中国生物学文摘2006，20，4： | 18 |
| 3 | 中国H3亚型流感病毒生态学与分子进化的研究显示文摘病毒生态学与分子进化是一门新兴的学科 ,研究病毒在各种环境中的关系 ,可以为今后病毒的研究与防治奠定基础。本研究首次详细对我国 14株鸭、鸡等禽流感和马、猪等动物的流感病毒的生态学与分子进化进行了分析研究 ,初步摸清了这些病毒在我国的流行与进化情况 ,为今后流感病毒疫苗的应用奠定了理论基础 。 | 崔尚金 李建伟 金红 李海燕 唐秀英 于康震 王秀荣 刘尚高 Y Guan K F Shortridge M Deries | 2002 | 中国预防兽医学报2002，24，2： | 5 |
| 4 | Oxygen and Nitrogen Effects on MC Carbide in K465 Nickel-Base Superalloy显示文摘Effects of oxygen and nitrogen on MC carbide in nickel-base superalloy K465 were investigated, because neither of the two gas elements was found to decide MC carbide morphology monotonically. The morphology of MC carbide under alloy solidified in conventional investment casting condition was observed to transform from script-type to block-type with the total oxygen and nitrogen content (gas content) in samples rising up from 1.2×10-6 mol/g to 2.6×10-6 mol/g. The area fraction and composition of the MC carbide also varied with increase of gas content. However, the morphology of MC carbide kept to be script-type even when gas content was up to 3.4×10-6 mol/g in samples solidified with a much higher cooling rate. These results indicate that effects of gas content on formation of MC carbide can be observed in specimens solidified with low cooling rate, but such changes in MC carbide cannot be found when the cooling rate is high. | Wang L N Zheng Q Sun X F Guan H R Hu Z Q | 2009 | 稀有金属材料与工程2009，38，A03： | 4 |
| 5 | An ordinal optimization based bidding strategy for electric power suppliers in the daily energy market显示文摘 | Guan X H HoYC(Larry) Lai F | 2001 | IEEE Trans on Power Svstems2001，16，4： | 2 |
| 6 | H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to duck 显示文摘 | Guan Y Peiris M Kong K F | 2002 | Virol2002，292，： | 1 |
| 7 | Superior efficacy of a Cremophor-fiee albumin-bound paclitaxel compared with solvent-based paclitaxel in Chinese patients with metastatic breast cancer显示文摘 | GUAN Z Z LI Q L FENG F Y | 2009 | Asian Pac J Clia Oncol2009，5，3： | 1 |
| 8 | Preparation and properties of Gd3+ and Y3+ co-doped ceria-based electrolytes for intermediate temperature solid oxide fuel cells 显示文摘 | GUAN X F ZHOU H P WANG Y N | 2008 | J Alloys Compd2008，464，： | 1 |
| 9 | 1,3-diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2显示文摘 | Sui Z Guan J Michael P F | 2000 | Bioorg Med Chem Lett2000，10，6： | 1 |
| 10 | Effect of enamel coating on oxidation and hot corrosion resistance of Ti-24Al-14Nb-3V显示文摘 | GUAN C H TANG Z L WANG F H WU W T | 2000 | Chinese J Mater Res2000，14，： | 1 |
| 11 | Cytotoxicity,oxidative stress,and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles显示文摘 | Guan R Kang T Lu F | 2012 | Nanoscale Res Lett2012，7，1： | 1 |
| 12 | Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia 显示文摘 | WANG P GUAN Y F DU H | 2012 | Autophagy2012，8，1： | 1 |
| 13 | Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP 显示文摘 | Guan F Villegas G Teichman J | 2006 | Am J Physiol Renal Physiol2006，291，2： | 1 |
| 14 | Steelmaking and refining coordinated scheduling problem with waiting time and transportation consideration 显示文摘 | Tang L X Guan J Hu (3 F | 2010 | Computers & Industrial Engineering2010，58，2： | 1 |
| 15 | Oxidation behavior and breakdown of an aluminide coating on DZ40M alloy at high temperatures显示文摘 | Liu P S Liang K M Zhou H Y Guan H R Sun X F Jin T Yang K N | 2001 | Oxidation of Metals2001，55，56： | 1 |
| 16 | Interaction of ganoderma triterpenes with docetaxel and cisplatin in cytotoxicity against human carcinoma cells显示文摘 | Yue Q X Guan S H Xie F B | 2008 | Chinese J Nat Med2008，6，5： | 1 |
| 17 | Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacety-lase inhibitors 显示文摘 | Guan P Sun F E Hou X B | 2012 | Bioorg Med Chem2012，20，12： | 1 |
| 18 | Sensitivity analysis of brake squeal tendency to substructures' modal parameters 显示文摘 | GUAN D H SU X D ZHANG F | 2006 | Journal of Sound and Vibration2006，291，12： | 1 |
| 19 | Microwave improvement of soy proteinisolate- saccharide graft reactions 显示文摘 | Guan J J Qiu A Y Liu X Y Hua Y F Ma Y H | 2006 | Food Chemistry2006，97，： | 1 |
| 20 | Physical Model of Stress and Deformation Microstructures in AISI 304L Austenitic Stainless Steel Induced by High-Current Pulsed Electron Beam Surface Irradiation 显示文摘 | Guan Q F Zhang Q Y Dong C | 2008 | ISIJ Int2008，48，： | 1 |
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