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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Characterization and activity studies of highly heavy metal resistant sulphate-reducing bacteria to be used in acid mine drainage decontamination 显示文摘 | Martins M Faleiro M L Barros R J | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 3 | Association of gamma glutamyltransferase,metabolic syndrome and cardiovascular risk显示文摘 | Marlins M C Faleiro L L Afonso B | 2010 | Acta Med Port2010，23，4： | 1 |
| 4 | Characterization and activity studies of highly heavy metal resistant sulphate-reducing bacteria to be used in acid mine drainage decontamination显示文摘 | Mónica Martins M. Leonor Faleiro Raúl J. Barros A. Raquel Veríssimo M. Alexandra Barreiros M. Clara Costa | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 5 | Characterization and activity studies of highly heavy metal resistant sulphate - reducing bacteria to be used in acid mine drainage decontamination显示文摘 | Martins M Faleiro M L Barros R J | 2009 | Journal of hazardous materials2009，166，2： | 1 |
| 6 | Composition of the essential oils of Thymus and Origanum species from Algeria and their antioxidant and antimicrobial activities显示文摘 | Hazzit M Baaliouamer A Faleiro M L | | 0，，17： | 1 |
| 7 | Antimicrobial activity of essential oils isolated from Portuguese endemic spe- cies of Thymus显示文摘 | FALEIRO M L MIGUEL M G LADEIRO F | 2002 | Lett Appl Microbiol2002，36，： | 1 |
| 8 | Mechanism of uranium(Ⅵ)removal by two anaerobic bacterial communities显示文摘 | Martins M Faleiro M L Da Costa A M R | 2010 | Journal of Hazardous Materials2010，184，13： | 1 |
| 9 | Antimicrobial activity of essential oils isolated from Portuguese endemic species of Thymus 显示文摘 | Faleiro M L Miguel M G Ladeiro F | 2003 | Lett Appl Micro- biol2003，36，1： | 1 |
| 10 | Biological sulphate reduction using food industry wastes as carbon sources 显示文摘 | Martins M Faleiro M L Barros R J | 2009 | Biodegradation2009，20，： | 1 |
| 11 | Anaerobic bio-removal of uranium(VI)and chromium(VI):Comparison of microbial community structure显示文摘 | MARTINS M FALEIRO M L CHAVES S | 2010 | J Hazard Mater2010，176，13： | 1 |
| 12 | Anaerobic bio-removal of uranium (Ⅵ) and chromium (Ⅵ): comparison of microbial community structure显示文摘 | Martins M Faleiro M L Chaves S Tenreio R Santos E Costa M C | 2010 | Journal of Hazardous Materials2010，176，1： | 1 |
| 13 | Mechanism of uranium (VI) removal by two anaerobic bacterial communities显示文摘 | Martins M Faleiro M L Da Costa A M R | 2010 | Journal of Hazardous Materials2010，184，13： | 1 |
| 14 | Mechanism of uranium (vi) removal by two anaerobic bacterial communities显示文摘 | Martins M Faleiro M L Costa A M R Chaves S Tenreiro R Matos A P | 2010 | Journal of Hazardous Materials2010，184，1： | 1 |
| 15 | Using genetic diversity information to establish core collections of Stylosanthes capitata and Stylosanthes macrocephala显示文摘 | Santos-Garcia M O Toledo-Silva G Sassaki R P Ferreira T H Resende R M Chiari L Karia C T Carvalho M A Faleiro F G Zucchi M I Souza A P | 2012 | Genetic and Molecular Biology2012，35，4： | 1 |
| 16 | Mechanism of uranium(VI) removal by two anaerobic bacterial communities显示文摘 | MARTINS M FALEIRO M L da COSTA A M R | 2010 | Journal of Hazardous Materials2010，184，13： | 1 |
| 17 | Antimicrobial activity of essential oils isolated from Portuguese endemic species of Thymus 显示文摘 | FALEIRO M L MIGUEL M G I ADEIRO F | 2003 | Lett Appl Microbiol2003，36，1： | 1 |
| 18 | Antimicrobial activity of essential oils isolated from Portuguese endemic species of Thymus显示文摘 | Faleiro M L Miguel M G Ladeiro F | 2002 | Lett Appl Microbiol2002，，36： | 1 |
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