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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | 25 Gbps low-voltage hetero-structured silicongermanium waveguide pin photodetectors for monolithic on-chip nanophotonic architectures显示文摘Near-infrared germanium(Ge) photodetectors monolithically integrated on top of silicon-on-insulator substrates are universally regarded as key enablers towards chip-scale nanophotonics, with applications ranging from sensing and health monitoring to object recognition and optical communications. In this work, we report on the highdata-rate performance pin waveguide photodetectors made of a lateral hetero-structured silicon-Ge-silicon(Si-Ge-Si) junction operating under low reverse bias at 1.55 μm. The pin photodetector integration scheme considerably eases device manufacturing and is fully compatible with complementary metal-oxide-semiconductor technology. In particular, the hetero-structured Si-Ge-Si photodetectors show efficiency-bandwidth products of^9 GHz at-1 V and ~30 GHz at-3 V, with a leakage dark current as low as ~150 nA, allowing superior signal detection of high-speed data traffic. A bit-error rate of 10-9 is achieved for conventional 10 Gbps, 20 Gbps, and25 Gbps data rates, yielding optical power sensitivities of-13.85 dBm,-12.70 dBm, and-11.25 dBm, respectively. This demonstration opens up new horizons towards cost-effective Ge pin waveguide photodetectors that combine fast device operation at low voltages with standard semiconductor fabrication processes, as desired for reliable on-chip architectures in next-generation nanophotonics integrated circuits. | DANIEL BENEDIKOVIC LéOPOLD VIROT GUY AUBIN FARAH AMAR BERTRAND SZELAG BAYRAM KARAKUS JEAN-MICHEL HARTMANN CARLOS ALONSO-RAMOS XAVIER LE ROUX PAUL CROZAT ERIC CASSAN DELPHINE MARRIS-MORINI CHARLES BAUDOT FRéDéRIC BOEUF JEAN-MARC FéDéLI CHRISTOPHE KOPP LAURENT VIVIEN | 2019 | Photonics Research2019，7，4： | 2 |
| 3 | Effects of selective alpha1- and alpha2- adrenergic blockade on coronary flow reserve after coronary stenting 显示文摘 | Gregorini L Marco J Farah B | 2002 | Circulation2002，106，23： | 1 |
| 4 | Effect of Roasting on the Forma- tion of Chlorogenic Acid Lactones in Cofee显示文摘 | Farah A Paulis T Trugo L C | 2005 | J of Agric and Food Chem2005，53，5： | 1 |
| 5 | Primaiy intra-vitreal Bevacizumab(Avastin) for diabetic macular edema-results from the pan-A-merican Collaborative Retina Study Group at 6- month follow-up显示文摘 | Frevalo FJ Fromow-Guerra J Quiroz-Mercado H Wu L Berro-cal MH Farah ME | 2007 | Ophthalmology2007，114，4： | 1 |
| 6 | The assessment of diffused light illumination and acetic acid rinse (microlux/DL)in the visualisation of oral mucosal lesions 显示文摘 | Mcintosh L McCullough MJ Farah CS | 2009 | Oral Oncol2009，45，12： | 1 |
| 7 | Production and application of microbial cellulose 显示文摘 | Jonas R Farah L F | 1998 | Polymer Degradation and Stability1998，59，： | 1 |
| 8 | Vacuum-assisted therapy for various wound types including diabetic foot ulcer显示文摘 | Farah R Gantus M Kogan L | 2011 | Harefuah2011，150，3： | 1 |
| 9 | Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro显示文摘 | HERRERA L FARAH RA PELLEGRINI VA | 2000 | Leukemia2000，14，5： | 1 |
| 10 | Production and application of microbial cellulose 显示文摘 | Jonas R Farah L F | 1998 | Polym Degrad Stab1998，59，13： | 1 |
| 11 | Effect of roasting on the for- mation of ehlorogenie acid laetones in coffee 显示文摘 | Farah A Paulis T Trugo L C | 2005 | J Agric Food Chem2005，53，5： | 1 |
| 12 | Effects of selective α1and α2 adrenergic blockde on coronary flow reserve afeer coronary stenriug显示文摘 | Gregoroni L Marco J Farah B | 2002 | Circulation2002，106，： | 1 |
| 13 | The psychological reality of the body schema: A test with normal participants 显示文摘 | Reed C L Farah M J | 1995 | Journal of Experimental Psychology: Human perception and Performance1995，21，： | 1 |
| 14 | Somatostatin in the rat rostral ventrolateral medulla:Origins and mechanism of action 显示文摘 | Bou Farah L Bowman BR Bokiniec P | 2016 | J Comp Neurol2016，524，2： | 1 |
| 15 | Effects of cement bases on the stresses and deflection in composite restorations显示文摘 | Farah JW Powers JM Dennison L | 1976 | J Dent Res1976，55，1： | 1 |
| 16 | Producation and application of micro- bialcellulose 显示文摘 | Jonas R Farah L | 1998 | Polymer Degradation and Stability1998，，5： | 1 |
| 17 | Effects of selective alphal-and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting 显示文摘 | Gregorini L Marco J Farah B | 2002 | Circulation2002，106，23： | 1 |
| 18 | Three-year safety and visual acuity results of epimacular 90strontium/90yttrium brachytherapy with bevacizumab for the treatment of subfoveal choroidal neovascularization secondary to age-related macular degeneration 显示文摘 | Favila MP Farah ME Santos A Carla L Fuji G Rossi J | 2012 | Retina2012，32，1： | 1 |
| 19 | Prevalence of polycystic ovary syndrome in women seeking treatment from community electrologists Alabama professional electrology association study group显示文摘 | Farah L Lazenby A J Boots L R | 1999 | J Reprod Med1999，44，10： | 1 |
| 20 | Moderate exercise prevents impaired Ca2+handling in heart of CO exposed rat:implication for sensitivity to ischemia-reperfusion显示文摘 | FARAH C MEYER G ANDRE L | 2010 | Am J Physiol Heart Circ Physiol2010，1，： | 1 |
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