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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Moringa oleif-era:bioactive compounds and nutritional potential显示文摘 | FERREIRA P M P FARIAS D F OLIVEIRA J T A | 2008 | Brazilian Journal ofNutrition2008，21，4： | 1 |
| 3 | Numerical characterization of the morphology of aggregated particles 显示文摘 | BRASIL A M FARIAS T L CARVALHO M G | 2001 | Journal of Aerosol Science2001，32，： | 1 |
| 4 | Computational analysis of coned-face spiral groove gas seals using the finite element method显示文摘 | Marco T C Faria | 2005 | Revue Europeenne des Elements2005，14，23： | 1 |
| 5 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 6 | Traveling waves for delayed reaction-diffusion equations with global response显示文摘 | Faria T Huang W Wu J | | 0，，： | 1 |
| 7 | 查看详情显示文摘 | Faria A L M ac Leod T C O | | 0，，： | 1 |
| 8 | Prognostic factors and out- come for nasopharyngeal carcinoma 显示文摘 | Farias T P Dias F L Lima R A | 2003 | Arch Otolalyngol Head Neek Surg2003，129，7： | 1 |
| 9 | On a planar system modelling a neuron network with memory显示文摘 | FARIA T | 2000 | Differential Equations2000，168，1： | 1 |
| 10 | 查看详情显示文摘 | Barros V P Faria A L M acLeod T C O | | 0，，： | 1 |
| 11 | Protective role of mitochondrial unsaturated lipids on the preservation of the apoptotic ability of cytochrome c exposed to singlet oxygen 显示文摘 | Rodrigues T Franca LP Faria PA | 2007 | Biol Chem2007，282，25： | 1 |
| 12 | An efficient finite element procedure for analysis of high-speed spiral groove gas face seals 显示文摘 | Faria M T C | 2001 | ASME Journal of Tribology2001，123，1： | 1 |
| 13 | Idea density measured in late life predicts subsequent cognitive trajectories: implications for the measurement of cognitive reserve 显示文摘 | Farias S T Chand V Bonnici L | 2012 | Journals of Gerontology2012，67，6： | 1 |
| 14 | Evaluation of Numerical Models for Simulation of Realworld Hot-stabilized Fuel Consumption and Emis sions of Gasoline Light duty Vehicles显示文摘 | SILVA C M FARIAS T L FREY H C | 2006 | Transportation Research Part D2006，11，5： | 1 |
| 15 | On the Numerical Modeling of High-Speed Hydrodynamic Gas Bearing 显示文摘 | Faria M T San Andres L | 2000 | Transactions of the ASME2000，122，： | 1 |
| 16 | Protective role of mitochondrial unsaturated lipids on the preservation of the apoptotic ability of cytochrome C exposed to singlet oxygen显示文摘 | Rodrigues T Franca LP Faria PA | 2007 | J Biol Chem2007，282，25： | 1 |
| 17 | Numerical characterization of the morphology of aggregated particles 显示文摘 | Brasil A M Farias T L Carvalho M G | 2001 | journal of Aerosol Science2001，32，： | 1 |
| 18 | In vitroDendrobium nobile plant growth and rooting in different sucrose concentra-tions显示文摘 | DE FARIA R T RODRIGUES F N OLIVERIRA L V R | 2004 | Horticultura Brasileira Brasília2004，22，4： | 1 |
| 19 | Fractal and projected structure properties of soot aggregates 显示文摘 | Koylü U O Faeth G M Farias T L | 1995 | Combustion and Flame1995，100，4： | 1 |
| 20 | Catalytic wet air oxidation of low molecular weight carboxylic acids using a carbon supported platinum catalyst显示文摘 | GOMES H T FIGUEIREDO J L FARIA J L | 2000 | Applied Catalysis B:Environmental2000，27，4： | 1 |
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