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| 1 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 2 | Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease显示文摘AIM:To investigate the efficacy of 6-mercaptopurine (6-MP) in cases of azathioprine (AZA) hypersensitivity in patients with inflammatory bowel disease. METHODS: Twenty nine previously confirmed Crohn’s disease (CD) (n = 14) and ulcerative colitis (UC) (n = 15) patients with a known previous (AZA) hypersensitivity reaction were studied prospectively. The 6-MP doses were gradually increased from 0.5 up to 1.0-1.5 mg/kg per day. Clinical activity indicies (CDAI/CAI), laboratory variables and daily doses of oral 5-ASA, corticosteroids, and 6-MP were assessed before and in the first, sixth and twelfth months of treatment. RESULTS: In 9 patients, 6-MP was withdrawn in the first 2 wk due to an early hypersensitivity reaction. Medication was ineffective within 6 mo in 6 CD patients, and myelotoxic reaction was observed in two. Data were evaluated at the end of the sixth month in 12 (8 UC, 4 CD) patients, and after the first year in 9 (6 UC, 3 CD) patients. CDAI decreased transiently at the end of the sixth month, but no significant changes were observed in the CDAI or the CAI values at the end of the year. Leukocyte counts (P = 0.01), CRP (P = 0.02), and serum iron (P = 0.05) values indicated decreased inflammatory reactions, especially in the UC patients at the end of the year, making the possibility to taper oral steroid doses. CONCLUSION: About one-third of the previously AZA- intolerant patients showed adverse effects on taking 6MP. In our series, 20 patients tolerated 6MP, but it was ineffective in 8 CD cases, and valuable mainly in ulcerative colitis patients. | Ferenc Nagy Tamás Molnár Zoltán Szepes Klaudia Farkas Tibor Nyári János Lonovics | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 3 | Initial study on copper CMP slurry chemistries显示文摘 | CARPIO R FARKAS J JAIRATH R | 1995 | Thin Solid Films1995，266，255： | 2 |
| 4 | GDNF-related factor persepin is widely distributed throughout the nervous system显示文摘 | Jaszai J Farkas L Galter D | 1998 | J Neurosci Res1998，53，4： | 1 |
| 5 | Networks in life: scaling properties and eigenvalue spectra显示文摘 | Farkas I J Derenyi L Jeong H | 2002 | Phys A2002，，314： | 1 |
| 6 | Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exoerine glands of adult mice显示文摘 | Jaszai J Janich P Farkas LM | 2007 | Histoehem Cell Biol2007，128，5： | 1 |
| 7 | Infection of dogs and cats with the Hong Kong influenza A (HSN2) virus during an epidemic period in Hungary显示文摘 | Romvary J Rozsa J Farkas E | 1975 | Acta veterinaria Academiae Seientiarum Hungaricae1975，25，23： | 1 |
| 8 | NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol - withdrawal in primary cultures of rat cortical neurones 显示文摘 | Nagy J Horvath C Farkas S | 2004 | Neurochem Int2004，44，1： | 1 |
| 9 | Vehicular communication 显示文摘 | FARKAS K HEIDEMANN J IFFODE L | 2006 | IEEE Pervasive Computing2006，5，4： | 1 |
| 10 | Paraclinoid internalcarotid artery aneurysm presenting as massive e- pistasis显示文摘 | KIM J V FARKAS J PUTAMAN C M | 2000 | Ann Otol Rhinol Laryngol2000，109，： | 1 |
| 11 | Self-organizing pedestrian movement显示文摘 | Dirk Helbing Peter Molnar Illes J Farkas | | 0，，： | 1 |
| 12 | Effects of low dose gamma radiation of sheltlife and microbiological safety of precut/prepared vegetables显示文摘 | Farkas J | 1997 | Adv Food Sci1997，19，： | 1 |
| 13 | Q uardigeminal nonaneurysmal subarachnoid haemorrhagea true variant perimesencephalic subarachnoid hemorrhage 显示文摘 | Schwatz TH Farkas J | 2003 | Clin Neurol Neurosurg2003，105，： | 1 |
| 14 | Minimum cost design of a welded orthogonally stiffened cylindrical shell 显示文摘 | Jarmai K Snyman J A Farkas J | 2006 | Computers and Structures2006，，84： | 1 |
| 15 | Experimental acute pancreatitis results in increasd blood-brain barrier permeability in the rat: a potential role for tumor necrosis factor and interleukin-6显示文摘 | Farkas G Marton J Nagy I | 1998 | Neurolsci Lett1998，242，3： | 1 |
| 16 | Administration of bromocriptine tablets in physiological and pathological hyper prolactine mic conditions显示文摘 | Farkas M Beczy J Gyetvai G | 1991 | Phamaceuticals Budapest1991，41，： | 1 |
| 17 | Stability and regularity results for a size-structured population model显示文摘 | FARKAS J Z HAGEN T | 2007 | Mathematical Analysis and Applications2007，328，： | 1 |
| 18 | Surgical management and complex treatment of infected pancreatic necrosis : 18-year experience at a sin- gle center显示文摘 | Farkas G Marton J Mahdi Y | 2006 | J Gastrointestinal Surg2006，10，2： | 1 |
| 19 | Spectra of ' Real - World' Graphs: Beyond the Semicircle Law 显示文摘 | Farkas I J Derenyi I Barabasi A L | 2001 | Physical Review E2001，64，02： | 1 |
| 20 | Experimental acute pancreastitis results in increased blood-brain barrier permeability in the rat:a potential role for tumor necrosis factor and interleukin 6显示文摘 | Farkas G Marton J Nagy Z | 1998 | Neurosci Lett1998，242，3： | 1 |
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