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| 1 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 2 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long‐term iodine prophylaxis and abundant iodine intake显示文摘 | IstvánSzabolcs JanPodoba JoachimFeldkamp OrsolyaDohán IldikóFarkas MihálynéSajgó Krisztina I.Takáts MiklósGóth LászlóKovács KatalinKressinszky PeterHnilica GézaSzilágyi | 2003 | Clinical Endocrinology2003，，1： | 2 |
| 4 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 5 | Dif-ferences in LPS-induced activation of bronchial epithelial cells (BEAS-2B) and type Ⅱ-like pneumocytes (A-549)显示文摘 | Schulz C Farkas L Wolf K | 2002 | Scand J Immunol2002，56，3： | 1 |
| 6 | GDNF-related factor persepin is widely distributed throughout the nervous system显示文摘 | Jaszai J Farkas L Galter D | 1998 | J Neurosci Res1998，53，4： | 1 |
| 7 | Networks in life: scaling properties and eigenvalue spectra显示文摘 | Farkas I J Derenyi L Jeong H | 2002 | Phys A2002，，314： | 1 |
| 8 | Anti-tumor necrosis factor-αinduced systemic lupus erythematosus in a patient with metastaticCrohn's disease-what is the role of anti-TNF antibody?显示文摘 | Farkas K Nagy F Kovács L | 2012 | J Crohn''sColitis2012，，： | 1 |
| 9 | Vehicular communication 显示文摘 | FARKAS K HEIDEMANN J IFFODE L | 2006 | IEEE Pervasive Computing2006，5，4： | 1 |
| 10 | VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats显示文摘 | FARKAS L FARKAS D ASK K | 2009 | Journal of Clinical Investigation2009，119，5： | 1 |
| 11 | Reduction of endogenous transforming growth factors β prevents ontogenetic neuron death显示文摘 | Krieglstein K Richter S Farkas L | 2000 | Nat Neurosci2000，3，11： | 1 |
| 12 | Monocyte-derived interferon-alpha primed dendritic cells in the pathogenesis of psoriasis: new pieces in the puzzle显示文摘 | Farkas A Kem6ny L | 2012 | Int Immunopharmacol2012，13，2： | 1 |
| 13 | Spectra of ' Real - World' Graphs: Beyond the Semicircle Law 显示文摘 | Farkas I J Derenyi I Barabasi A L | 2001 | Physical Review E2001，64，02： | 1 |
| 14 | Organ-preserving pancreatic head resection in chronic pancreatitis 显示文摘 | Farkas G Leindler L Daroczi M | 2003 | Br J Surg2003，90，1： | 1 |
| 15 | The reaction between hypochlorite and bromides 显示文摘 | FARKAS L LEWIN M BLOCH R | 1949 | J Am Chem Soc1949，71，： | 1 |
| 16 | Genomic and phylogenetic analyses of an adenovirus isolated from a corn snake(Elapheguttata) imply a common origin with member of the proposed new genus Atadenovirus显示文摘 | Szilvia L Farkas M Benk P | 2002 | Journal of General Virology2002，83，： | 1 |
| 17 | VEGF ameliorates pulmonary hyper- tension through inhibition of endothe- lial apoptosis in experimental lung fi- brosis in rats显示文摘 | Farkas L Farkas D Ask K | 2009 | J Clin Invest2009，119，5： | 1 |
| 18 | Muramyldipeptide modu- lates CXCL-8 release of BEAS-2B cells via NOD2 显示文摘 | Farkas L Stoelcked B Jentsch N | 2008 | Stand J Immunol2008，68，3： | 1 |
| 19 | Polymorph screening of an active material显示文摘 | P. Láng V. Kiss R. Ambrus G. Farkas P. Szabó-Révész Z. Aigner E. Várkonyi | 2013 | Journal of Pharmaceutical and Biomedical Analysis2013，，： | 1 |
| 20 | Vehicular communication 显示文摘 | FARKAS K HEIDEMANN J ITI'ODE L | 2006 | IEEE Pervasive Computing2006，5，4： | 1 |
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