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| 1 | Diagnosis of pancreatic tumors by endoscopic ultrasound-guided fine-needle aspiration显示文摘AIM: To evaluate the diagnostic accuracy of endoscopic ultrasound-guided fi ne-needle aspiration (EUS-FNA) for pancreatic solid tumors larger or smaller than 3 cm, and cystic lesions. METHODS: From January/1997 to December/2006, 611 patients with pancreatic tumors were subjected to EUS-FNA. The fi nal diagnosis was obtained either by surgery (356 cases) or after a mean clinical follow-up of 11.8 mo in the remaining patients. RESULTS: There were 405 solid tumors, 189 cystic lesions and 17 mixed. Pancreatic specimens for cytological assessment were successfully obtained by EUS-FNA in 595 (97.4/) cases. There were 352 (57.6/) malignancies and 259 (42.4/) benign tumors. Among the malignancies, pancreatic adenocarcinomas accounted for 67/ of the lesions. Overall, the sensitivity, specifi city, positive and negative predictive values, and accuracy of EUS-FNA were, respectively, 78.4/, 99.2/, 99.3/, 77.2/ and 87.2/. Specif ically for solid tumors, the same parameters for neoplasms larger and smaller than 3 cm were, respectively, 78.8/ vs 82.4/, 100/ vs 98.4/, 100/ vs 99/, 54.8/ vs 74.1/ and 83.1/ vs 87.8/. For cystic lesions, the values were, respectively, 72.2/, 99.3/, 97.5/, 91/ and 92.2/. CONCLUSION: EUS-FNA can be used to sample pancreatic tumors in most patients. Even though the negative predictive value is inadequate for large solid tumors, the results are rather good for small solid tumors, especially concerning the sensitivity, negative predictive value and diagnostic accuracy. Among all pancreatic lesions, EUS-FNA for cystic lesions canreveal the best negative predictive value and diagnostic accuracy, both higher than 90/. | José Celso Ardengh César Vivian Lopes Luiz Felipe Pereira de Lima Juliano Rodrigues de Oliveira Filadélfi o Venco Giulio Cesare Santo José Luiz Pimenta Módena | 2007 | World Journal of Gastroenterology2007，13，22： | 17 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 4 | Vaccination with recombinant Clostridium perfringens toxoidsαandβpromotes elevated antepartum and passive humoral immunity in swine显示文摘 | Felipe M S Fabricio R C Prhiscylla S P | 2013 | Vaccine2013，31，： | 1 |
| 5 | Vaccination with recombinant Clostridium periringens toxoids aandβpromotes elevated antepartum and passive humoral im- munity in swine显示文摘 | Felipe M S Fabricio R C Carlos E P C | 2013 | Vaccine2013，31，： | 1 |
| 6 | Utilization of sugarcane bagasse hemicellulosic hydrolysate by Candida guilliermondii for xylitol production显示文摘 | Roberto I C Felipe M G Lacis L C et ol | 1991 | Bioresource Technol1991，36，： | 1 |
| 7 | Batch xylitol production by Candida guilliermondii FTI20037from sugarcane bagasse hemicellulosic hydrolyzate at controlled pH values显示文摘 | R C L B Rodrigues M G A Felipe I C Roberto | 2003 | Bioprocess Biosyst Eng2003，26，： | 1 |
| 8 | Re- sponse surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables显示文摘 | Rodrigues R C L B Felipe M G A Silva J B A | 2003 | Process Biochem- istry2003，38，8： | 1 |
| 9 | Bioconversion of rice straw hemicelulose hydrolysate for the production of xylitol:Effect of pH and nitrogen source显示文摘 | ROBERTO I C C SILVA S S FELIPE M G A | 1996 | Appl Biochem Biotech1996，57，1： | 1 |
| 10 | Region merging techniques using information theory statistical measures显示文摘 | Felipe C Ferran M | 2010 | IEEE Transactions on Image Processing2010，19，6： | 1 |
| 11 | Inhibition of cell proliferation and migration by oxidative stress from ascorbate-driven juglone redox cycling in hu- man bladder-derived T24 cells 显示文摘 | KVIECINSKI M R PEDROSA R C FELIPE K B | 2012 | Biochemical and Bio- physical Research Communications2012，421，2： | 1 |
| 12 | Anaerobic codigestion of municipal, farm, and industrial organic waste: a survey of recent literature显示文摘 | Felipe A M Parviz S Hub H J C | 2006 | Water Environment Research2006，78，6： | 1 |
| 13 | The influence of pH,temperature and hydrolysate concentration on the removal of volatile and non-volatile compounds from sugarcane bagasse hemicellulosic hydrolysate treated with activated charcoal before or after vacuum evaporation显示文摘 | Rodrigues R C L B Felipe M G A Almeida E | 2001 | Braz J Chem Eng2001，18，： | 1 |
| 14 | The role of NADH- oxidation in acetoin and diacetyl production from glucose in Lactococcus lactis 显示文摘 | LOPEZ DE FELIPE F STARRENBURG M J C HUGENHOLTZ J | 1997 | FEMS Microbiol Lett1997，156，： | 1 |
| 15 | Response surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables 显示文摘 | Rodrigues R C L B Felipe M G A Silva J B A | 2003 | Process Biochemistry2003，38，： | 1 |
| 16 | Demecolcine effects on microtubule kinetics and on chemically assisted enucleation of bovine oocytes显示文摘 | Naiara Z S Felipe P Simone C M | 2009 | Cloning Stem Cells2009，43，： | 1 |
| 17 | Treatment of erythrodermic psoriasis withetanercept显示文摘 | Esposito M Mazzotta A de Felipe C | 2006 | Br J Dermatol2006，155，1： | 1 |
| 18 | Nucleotide conformational change induced by cationic bilayers显示文摘 | ISELI L NANTES A FELIPE M C | 2003 | Arch Biochem Biophys2003，416，1： | 1 |
| 19 | Response surface methodology for xylitol production from sugarcane bagasse hemicellulosic hydrolyzate using controlled vacuum evaporation process variables 显示文摘 | Rodrigues R C L B Felipe M G A Almeida e Silva J B Vitolo M | 2003 | Process Biochemistry2003，38，8： | 1 |
| 20 | Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms 显示文摘 | Cruz G M P Felipe C F B Scorza F A | 2013 | Pharmacology Biochemistry and Behavior2013，104，： | 1 |
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