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| 1 | Ginsenoside Rh2 inhibits glioma cell proliferation by targeting microRNA-128显示文摘 | Nan WU Guo-cai WU Rong HU Mei LI Hua FENG | 2011 | Acta Pharmacologica Sinica2011，32，3： | 33 |
| 2 | Prevention and Treatment of Osteoporosis with Chinese Herbal Medicines显示文摘In this paper,laboratory reports,medication rules,formulating principles,and research methods are summarized and analyzed,including single herb,compound herbs,and the problems in the prevention and treatment of osteoporosis(OP) within the past decade.With widely recognized efficacy,satisfying achievements have been achieved in preventing and treating OP with Chinese herbal medicines(CHM).However,due to the complex constituents,the pharmacological activities and mechanism of CHM are not clear yet,and there is no unified standard on the diagnosis and syndrome differentiation of OP and the efficacy evaluation of CHM in the treatment.Accordingly,the research in the future should focus on the pharmacology and standardization of CHM in treating OP. | ZHAO Xiao-ling1,2,FENG Yu-xiong1,2,3,PENG Yong1,2 1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China 2.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines,Ministry of Education,Beijing 100193,China 3.College of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530001,China | 2012 | Chinese Herbal Medicines2012，4，4： | 28 |
| 3 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 4 | Parishin C's prevention of Aβ_(1–42)-induced inhibition of long-term potentiation is related to NMDA receptors显示文摘The rhizome of Gastrodia elata(GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection of soluble Aβ1–42oligomers model of LTP injury was used. We investigated the effects of parishin C on the improvement of LTP in soluble Aβ1–42oligomer–injected rats and the underlying electrophysiological mechanisms. Parishin C(i.p. or i.c.v.) significantly ameliorated LTP impairment induced by i.c.v. injection of soluble Aβ1–42oligomers. In cultured hippocampal neurons,soluble Aβ1–42oligomers significantly inhibited NMDAR currents while not affecting AMPAR currents and voltage-dependent currents. Pretreatment with parishin C protected NMDA receptor currents from the damage induced by Aβ. In summary, parishin C improved LTP deficits induced by soluble Aβ1–42oligomers. The protection by parishin C against Aβ-induced LTP damage might be related to NMDA receptors. | Zhihui Liu Weiping Wang Nan Feng Ling Wang Jiangong Shi Xiaoliang Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 25 |
| 5 | Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes显示文摘目的: 现在的学习的目的是观察效果抵抗在在在导出老鼠的 hepatocytes.Methods 的胰岛素敏感度和葡萄糖输出上: 老鼠肝细胞瘤房间线 H4IIE 与有教养、刺激抵抗在; supernant 葡萄糖和肝糖内容被检测。胰岛素受体底层(红外)-1 和 IRS-2,蛋白质激酶 B/Akt,肝糖 synthase kinase-3 (3 (GSK-3p ) , suppress 或表明 3 的 cytokine (SOCS-3 ) ,蛋白质内容,以及磷酸化地位被西方的弄污估计。对 SOCS-3 指导的特定的反感觉 oligodeoxynucleotides 习惯于击倒的 SOCS-3.Results :抵抗素导致了抗胰岛素性,但是在老鼠肝细胞瘤房间的affect 葡萄糖输出没衬里 H4IIE.Resistin 胰岛素的稀释多重效果包括刺激胰岛素的肝糖合成和红外的磷酸化,蛋白质激酶 B/Akt ,象 GSK-3beta.Resistin 一样,处理显著地导致了基因和 SOCS-3 的蛋白质表示,胰岛素发信号的一个已知的禁止者。而且,对 SOCS-3 处理指导的特定的反感觉 oligodeoxynucleotide 阻止了抵抗在从反对胰岛素 action.Conclusion : 主要功能抵抗在在肝上是导致胰岛素 resistance.SOCS-3 感应的可以贡献胰岛素在 H4HE hepatocytes 发信号的调停 resistin 的抑制。 | Feng LIU Tao YANG Bin WANG Min ZHANG Nan GU Jie QIU Hong-qi FAN Chun-mei ZHANG Li FEI Xiao- qing PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2008 | Acta Pharmacologica Sinica2008，29，1： | 21 |
| 6 | Internet of Vehicles in Big Data Era显示文摘As the rapid development of automotive telematics,modern vehicles are expected to be connected through heterogeneous radio access technologies and are able to exchange massive information with their surrounding environment. By significantly expanding the network scale and conducting both real-time and long-term information processing, the traditional Vehicular AdHoc Networks(VANETs) are evolving to the Internet of Vehicles(Io V), which promises efficient and intelligent prospect for the future transportation system. On the other hand, vehicles are not only consuming but also generating a huge amount and enormous types of data, which is referred to as Big Data. In this article, we first investigate the relationship between Io V and big data in vehicular environment, mainly on how Io V supports the transmission, storage, computing of the big data, and how Io V benefits from big data in terms of Io V characterization,performance evaluation and big data assisted communication protocol design. We then investigate the application of Io V big data in autonomous vehicles. Finally, the emerging issues of the big data enabled Io V are discussed. | Wenchao Xu Haibo Zhou Nan Cheng Feng Lyu Weisen Shi Jiayin Chen Xuemin (Sherman) Shen | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 19 |
| 7 | Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles显示文摘瞄准:在 basaland 上估计 resistin 的行动的效果和机制在老鼠的刺激胰岛素的葡萄糖举起骨胳的肌肉 cells.Methods:老鼠 myoblasts ( L6 ) werecultured 并且区分了进刺激与单个商业 resistin 跟随的 myotubes ( 130 ng/mL , 0-24 h )或从有 resistin-expressingvectors 的 293-T 房间 transfected 的有教养的上层清液( 130 ng/mL , 0-24 h ) .Liquid 焕发数被用来测定[ 3H ]胰岛素敏感的葡萄糖 transporters GLUT4 andGLUT1 的 2-deoxyglucoseuptake .The translocation , 联系synaptosomal 的蛋白质 23 ( SNAP23 )并且充斥蛋白质内容,以及 tyrosinephosphorylation statu 有单个 resistin 或有教养的 supernatantcontaining recombinant resistin 的 L6 myotubes 的处理减少了基础、刺激胰岛素的 2-deoxyglucose 举起 andimpaired 刺激胰岛素的 GLUT4 translocation.While SNAP23 蛋白质内容被减少, noeffects 在 GLUT4 或没有影响它的蛋白质内容,也减少的 insulin-stimulatedIRS-1 酷氨酸 phosphorylation 铺平的 GLUT1 蛋白质内容 Resistin 被注意从有 resistin-expr 的 293-T 房间 transfected 的效果 ofrecombinant resistin Resistin 调整了 IRS-1 功能并且减少响应 SNAP23 mayhave 的 insulin.The downregulated 表示的 GLUT4translocation 和葡萄糖举起部分由 resistin 处理 Theseobservations 热点归因于葡萄糖举起的减少在到肥胖的类型 2 diabetesrelated 的 pathophysiology 的 resistin 的潜在的角色。 | Hong-qi FAN Nan GU Feng LIU Li FEI Xiao-qin PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2007 | Acta Pharmacologica Sinica2007，28，3： | 16 |
| 8 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 9 | MicroRNA-663 induces immune dysregulation by inhibiting TGF-β1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus显示文摘Mesenchymal stem cells(MSCs)are critical for immune regulation.Although several microRNAs(miRNAs)have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function,the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear.Here,we show that patients with systemic lupus erythematosus(SLE)display a unique miRNA signature in bone marrow-derived MSCs(BMSCs)compared with normal controls,among which miR-663 is closely associated with SLE disease activity.MiR-663 inhibits the proliferation and migration of BMSCs and impairs BMSC-mediated downregulation of follicular T helper(Tfh)cells and upregulation of regulatory T(Treg)cells by targeting transforming growth factorβ1(TGF-β1).MiR-663 overexpression weakens the therapeutic effect of BMSCs,while miR-663 inhibition improves the remission of lupus disease in MRL/lpr mice.Thus,miR-663 is a key mediator of SLE BMSC regulation and may serve as a new therapeutic target for the treatment of lupus. | Linyu Geng Xiaojun Tang Kangxing Zhou Dandan Wang Shiying Wang Genhong Yao Weiwei Chen Xiang Gao Wanjun Chen Songtao Shi Nan Shen Xuebing Feng Lingyun Sun | 2019 | Cellular & Molecular Immunology2019，16，3： | 16 |
| 10 | Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation显示文摘 | Li YANG Li-ping SHI Hai-jun CHEN Xian-kun TONG Gui-feng WANG Yang-ming ZHANG Wen-long WANG Chun-lan FENG Pei-lan HE Feng-hua ZHU You-hua HAO Bao-ju WANG Dong-liang YANG Wei TANG Fa-jun NAN Jian-ping ZUO | 2014 | Acta Pharmacologica Sinica2014，35，3： | 14 |
| 11 | Chemical fertilizers could be completely replaced by manure to maintain high maize yield and soil organic carbon(SOC)when SOC reaches a threshold in the Northeast China Plain显示文摘The combined use of chemical and organic fertilizers is considered a good method to sustain high crop yield and enhance soil organic carbon(SOC),but it is still unclear when and to what extent chemical fertilizers could be replaced by organic fertilizers.We selected a long-term soil fertility experiment in Gongzhuling,Northeast China Plain to examine the temporal dynamics of crop yield and SOC in response to chemical nitrogen,phosphorus,and potassium(NPK) fertilizers and manure,applied both individually and in combination,over the course of three decades(1980-2010).We aimed to test 1) which fertilizer application is the best for increasing both maize yield and SOC in this region,and 2) whether chemical fertilizers can be replaced by manure to maintain high maize yield and enhance SOC,and if so,when this replacement should be implemented.We observed that NPK fertilizers induced a considerable increase in maize yield in the first 12 years after the initiation of the experiment,but manure addition did not.In the following years,the addition of both NPK fertilizers and manure led to an increase in maize yield.SOC increased considerably in treatments with manure but remained the same or even declined with NPK treatments.The increase in maize yield induced by NPK fertilizers alone declined greatly with increasing SOC,whereas the combination of NPK and manure resulted in high maize yield and a remarkable improvement in SOC stock.Based on these results we suggested that NPK fertilizers could be at least partially replaced by manure to sustain high maize yield after SOC stock has reached 41.96 Mg C ha^(-1) in the Northeast China Plain and highly recommend the combined application of chemical fertilizers and manure(i.e.,60 Mg ha^(-1)). | LI Hui FENG Wen-ting HE Xin-hua ZHU Ping GAO Hong-jun SUN Nan XU Ming-gang | 2017 | Journal of Integrative Agriculture2017，16，4： | 13 |
| 12 | 3D N,O-Codoped Egg-Box-Like Carbons with Tuned Channels for High Areal Capacitance Supercapacitors显示文摘Functional carbonaceous materials for supercapacitors(SCs)without using acid for post-treatment remain a substantial challenge.In this paper,we present a less harmful strategy for preparing three-dimensional(3D)N,O-codoped egg-box-like carbons(EBCs).The as-prepared EBCs with opened pores provide plentiful channels for ion fast transport,ensure the e ective contact of EBCs electrodes and electrolytes,and enhance the electron conduction.The nitrogen and oxygen atoms doped in EBCs improve the surface wettability of EBC electrodes and provide the pseudocapacitance.Consequently,the EBCs display a prominent areal capacitance of 39.8μF cm-2(340 F g-1)at 0.106 m A cm-2 in 6 M KOH electrolyte.The EBC-based symmetric SC manifests a high areal capacitance to 27.6μF cm-2(236 F g-1)at 0.1075 m A cm-2,a good rate capability of 18.8μF cm-2(160 F g-1)at 215 m A cm-2 and a long-term cycle stability with only 1.9%decay after 50,000 cycles in aqueous electrolyte.Impressively,even in all-solid-state SC,EBC electrode shows a high areal capacitance of 25.0μF cm-2(214 F g-1)and energy density of 0.0233 m Wh cm-2.This work provides an acid-free process to prepare electrode materials from industrial by-products for advanced energy storage devices. | Feng Wei Xiaojun He Lianbo Ma Hanfang Zhang Nan Xiao Jieshan Qiu | 2020 | Nano-Micro Letters2020，12，7： | 13 |
| 13 | Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model显示文摘 | Si-qi FENG Nan AA Jian-liang GENG Jing-qiu HUANG Run-bin SUN Chun GE Zhi-jian YANG Lian-sheng WANG Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，11： | 12 |
| 14 | Devonian Sea-Level Change Rhythms in South China and Coupling Relationships Among the Earth-spheres显示文摘Twenty orthosequences and their corresponding sea-level change (SLC) cycles have been recognized in the Devonian overlying the Caledonian unconformity, of which 9, 5.5 and 5.5 occurred in the Lower, Middle and Upper Devonian respectively. They can be grouped into 4 orthosequence sets, in which the maximum flooding surfaces lie in the sulcutus Zone (D12), perbonus Zone (D13), Middle and Upper varcus Zone (D22) and gigas Zone (D21) respectively. Four instant palaeogeographical reconstructions of South China have been made in the Emsian and Givetian. Devonian sea-level change rhythms of South China can be divided into 3 categories: the autorhythmic, the worldwide and regional allorhythmic, and the coupling-rhythmic. They developed respectively in the Famennian, Pragian, Eifelian, Lochkovian, Emsian, Givetian, Frasnian and the F / F (between the Frasnian and Famennian) event. The cause of the worldwide allorhythmic SLC of the Pragian and Eifelian under comparatively dry, warm and tranquil conditions may | Gong Yiming,Faculty of Earth Science, China University of Geosciences, Wuhan,Hubei, 430074Wu Yi,Guangxi Institute of Geology, Nanning, GuangxiDu Yuansheng, Feng Qinglai and Liu BenpeiChina University of Geosciences, Wuhan, Hubei, 430074 | 1997 | Acta Geologica Sinica(English Edition)1997，71，4： | 10 |
| 15 | Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs显示文摘钾 2-(1-hydroxypentyl ) 安息香酸盐(dl-PHPB ) 是被用来治疗 ischemic 击的 3-n-butylphthalide (dl-NBP ) 支持药的一篇小说。当前, dl-PHPB 在在中国的阶段 II-III 临床的审判。在这研究,我们在 vitro 并且在 vivo 调查了变换和 dl-PHPB 的 pharmacokinetics 侧面。到 dl-NBP 的 dl-PHPB 的变换是 pH-dependent, 和钙依赖者,并且 paraoxonase 在老鼠血浆为变换作为主要的酶被识别。pharmacokinetics,织物分发和 dl-PHPB 的排泄被学习并且与在老鼠和狗的 dl-NBP 的平等者臼齿的剂量相比。在里面 vivo 研究证明 dl-PHPB 能快速并且完全被变换成 dl-NBP。在静脉内的 dl-PHPB 管理以后的变换 dl-NBP 的血浆集中时间功课是将近与那一样在平等者臼齿的 dl-NBP 以后。C 分别地,在在老鼠和狗的口头的 dl-PHPB 管理以后的 dl-NBP 的最大 和 AUC 比在口头的 dl-NBP 管理以后的那些在 60% 和 170% 是更高的。dl-PHPB 的织物分发的分析表明那变换 dl-NBP 首先在脂肪,大脑和胃被散布。在大脑, dl-NBP 的层次在 dl-PHPB 处理由以后是相对更高的口头上地比在有平等者臼齿的 dl-NBP 的处理以后。近似 dl-NBP 的 3%-4% 与 dl-PHPB 或 dl-NBP 在 dosing 以后在 72 h 以内被排泄,但是没有 dl-PHPB 在尿或排汇物排泄物被检测。我们的结果证明 dl-PHPB 的变换在口头或静脉内的管理以后是快的。而且, dl-PHPB 的 bioavailability 显然比 dl-NBP 的好。 | Jiang LI Shao-feng XU Ying PENG Nan FENG Ling WANG Xiao-liang WANG | 2018 | Acta Pharmacologica Sinica2018，39，2： | 10 |
| 16 | Molecular heterogeneity of anti-PD-1/PD-L1 immunotherapy efficacy is correlated with tumor immune microenvironment in East Asian patients with non-small cell lung cancer显示文摘Objective:The aim of this study was to investigate how the tumor immune microenvironment differs regarding tumor genomics,as well as its impact on prognoses and responses to immunotherapy in East Asian patients with non-small cell lung cancer(NSCLC).Methods:We performed an integrated analysis using publicly available data to identify associations between anti-programmed death 1(PD-1)/programmed death-ligand 1(PD-L1)immunotherapy efficacy and classic driver oncogene mutations in East Asian NSCLC patients.Four pooled and clinical cohort analyses were used to correlate driver oncogene mutation status and tumor microenvironment based on PD-L1 and CD8+tumor-infiltrating lymphocytes(TILs).Immune infiltrating patterns were also established for genomic NSCLC subgroups using the CIBERSORT algorithm.Results:Based on East Asian NSCLC patients,TIDE analyses revealed that for anti-PD-1/PD-L1 immunotherapy,epidermal growth factor receptor(EGFR)-mutant and anaplastic lymphoma kinase(ALK)-rearranged tumors yielded inferior responses;however,although Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors responded better,the difference was not statistically significant(EGFR:P=0.037;ALK:P<0.001;KRAS:P=0.701).Pooled and clinical cohort analyses demonstrated tumor immune microenvironment heterogeneities correlated with oncogenic patterns.The results showed remarkably higher PD-L1-and TIL-positive KRAS-mutant tumors,suggesting KRAS mutations may drive an inflammatory phenotype with adaptive immune resistance.However,the EGFR-mutant or ALK-rearranged groups showed a remarkably higher proportion of PD-L1-/TIL-tumors,suggesting an uninflamed phenotype with immunological ignorance.Notably,similar to triple wild-type NSCLC tumors,EGFR L858R-mutant tumors positively correlated with an inflammatory phenotype,suggesting responsiveness to anti-PD-1/PD-L1 immunotherapy(P<0.05).Furthermore,the CIBERSORT algorithm results revealed that EGFR-mutant and ALK-rearranged tumors were characterized by an enriched resting memory CD4+T cell population(P<0.001),as well as a lack of CD8+T cells(P<0.01),and activated memory CD4+T cells(P=0.001).Conclusions:Our study highlighted the complex relationships between immune heterogeneity and immunotherapeutic responses in East Asian NSCLC patients regarding oncogenic dependence. | Runsen Jin Chengming Liu Sufei Zheng Xinfeng Wang Xiaoli Feng Hecheng Li Nan Sun Jie He | 2020 | Cancer Biology & Medicine2020，17，3： | 10 |
| 17 | 6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy显示文摘BACKGROUND To date,there has been no effective treatment for intervertebral disc degeneration(IDD).Nucleus pulposus-derived mesenchymal stem cells(NPMSCs)showed encouraging results in IDD treatment,but the overexpression of reactive oxygen species(ROS)impaired the endogenous repair abilities of NPMSCs.6-gingerol(6-GIN)is an antioxidant and anti-inflammatory reagent that might protect NPMSCs from injury.AIM To investigate the effect of 6-GIN on NPMSCs under oxidative conditions and the potential mechanism.METHODS The cholecystokinin-8 assay was used to evaluate the cytotoxicity of hydrogen peroxide and the protective effects of 6-GIN.ROS levels were measured by 2´7´-dichlorofluorescin diacetate analysis.Matrix metalloproteinase(MMP)was detected by the tetraethylbenzimidazolylcarbocyanine iodide assay.TUNEL assay and Annexin V/PI double-staining were used to determine the apoptosis rate.Additionally,autophagy-related proteins(Beclin-1,LC-3,and p62),apoptosisassociated proteins(Bcl-2,Bax,and caspase-3),and PI3K/Akt signaling pathwayrelated proteins(PI3K and Akt)were evaluated by Western blot analysis.Autophagosomes were detected by transmission electron microscopy in NPMSCs.LC-3 was also detected by immunofluorescence.The mRNA expression of collagen II and aggrecan was evaluated by real-time polymerase chain reaction(RT-PCR),and the changes in collagen II and MMP-13 expression were verified through an immunofluorescence assay.RESULTS 6-GIN exhibited protective effects against hydrogen peroxide-induced injury in NPMSCs,decreased hydrogen peroxide-induced intracellular ROS levels,and inhibited cell apoptosis.6-GIN could increase Bcl-2 expression and decrease Bax and caspase-3 expression.The MMP,Annexin V-FITC/PI flow cytometry and TUNEL assay results further confirmed that 6-GIN treatment significantly inhibited NPMSC apoptosis induced by hydrogen peroxide.6-GIN treatment promoted extracellular matrix(ECM)expression by reducing the oxidative stress injury-induced increase in MMP-13 expression.6-GIN activated autophagy by increasing the expression of autophagy-related markers(Beclin-1 and LC-3)and decreasing the expression of p62.Autophagosomes were visualized by transmission electron microscopy.Pretreatment with 3-MA and BAF further confirmed that 6-GIN-mediated stimulation of autophagy did not reduce autophagosome turnover but increased autophagic flux.The PI3K/Akt pathway was also found to be activated by 6-GIN.6-GIN inhibited NPMSC apoptosis and ECM degeneration,in which autophagy and the PI3K/Akt pathway were involved.CONCLUSION 6-GIN efficiently decreases ROS levels,attenuates hydrogen peroxide-induced NPMSCs apoptosis,and protects the ECM from degeneration.6-GIN is a promising candidate for treating IDD. | Li-Ping Nan Feng Wang Yang Liu Zhong Wu Xin-Min Feng Jun-Jian Liu Liang Zhang | 2020 | World Journal of Stem Cells2020，12，12： | 9 |
| 18 | Simultaneous additive and subtractive three-dimensional nanofabrication using integrated two-photon polymerization and multiphoton ablation显示文摘Modern three-dimensional nanofabrication requires both additive and subtractive processes.However,both processes are largely isolated and generally regarded as incompatible with each other.In this study,we developed simultaneous additive and subtractive fabrication processes using two-photon polymerization followed by femtosecond(fs)laser multiphoton ablation.To demonstrate the new capability,submicrometer polymer fibers containing periodic holes of 500-nm diameter and microfluidic channels of 1-mm diameter were successfully fabricated.This method combining both two-photon polymerization and fs laser ablation improves the nanofabrication efficiency and enables the fabrication of complex three-dimensional micro-/nanostructures,promising for a wide range of applications in integrated optics,microfluidics and microelectromechanical systems. | Wei Xiong Yun Shen Zhou Xiang Nan He Yang Gao Masoud Mahjouri-Samani Lan Jiang Tommaso Baldacchini Yong Feng Lu | 2012 | Light(Science & Applications)2012，1，1： | 9 |
| 19 | O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),emerged in late 2019 and has since caused a pandemic.Although there have been extensive studies worldwide,our understanding of this newly emerged pathogen is far from sufficient.The pathogenesis of the SARS-CoV-2 infection is not fully understood,although a“two-stage”hypothesis was proposed in our previous study. | Wenmin Tian Delin Li Nan Zhang Guijie Bai Kai Yuan Haixia Xiao Feng Gao Yang Chen Catherine C.L.Wong George Fu Gao | 2021 | Cell Research2021，31，10： | 9 |
| 20 | First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering显示文摘The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current interest.Elastic scattering is a useful probe for investigating the size and surface diffuseness of exotic nuclei.The development of rare isotope accelerators offers opportunities for such studies.To date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite scarce.In this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb barrier.The angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same energy.This work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei. | Wei Nan Bing Guo Cheng-Jian Lin Lei Yang Dong-Xi Wang Yang-Ping Shen Bing Tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming Jia Yun-Ju Li Chen Chen Li-Hua Chen Qi-Wen Fan Xin-Yue Li Gang Lian Jian-Cheng Liu Tian-Peng Luo Nan-Ru Ma Rui-Gang Ma Xie Ma Ying-Jun Ma Wei-Ke Nan Dan-Yang Pang You-Bao Wang Pei-Wei Wen Feng Yang Yong-Jin Yao Sheng Zeng Hao Zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong Li Tian-Jue Zhang Wei-Ping Liu BRIF Collaboration | 2021 | Nuclear Science and Techniques2021，32，5： | 9 |
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