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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 3 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 4 | A controlled clinical trial of high -dose methylprednisolone in the treatment of severe sepsis and septic shock显示文摘 | Bone R C Fisher C J Clemmer T P | 1987 | N Engl J Med1987，317，： | 2 |
| 5 | Relation of cerebral vasospasm to subaraclmoid hemorrhage visualized by computerized to mographic scanning显示文摘 | FISHER C M KISTLER J P DAVIS J M | 1980 | Neurosurgery1980，6，： | 1 |
| 6 | Arsenic uptake, cytoxocity and detoxification studied in mammalian cells in culture 显示文摘 | Fisher A B Buchet J P Lauwerys RR | 1985 | Arch Toxicol1985，57，3： | 1 |
| 7 | Joint toque control by a direct feedback for industrial robots显示文摘 | LUH J Y S FISHER W D RICHARD P C P | 1995 | IEEE Trans on Aut Contl1995，64，20： | 1 |
| 8 | The Sensitivity of Two Distributed Non-point Ssource Pollution Models to the Spatial Arrangement of the Landscape显示文摘 | Fisher P Abrahart R J Herbinger W | 1997 | Hydrol Process1997，，11： | 1 |
| 9 | Reynolds stress and TKE production in an estuary with a tidal bore显示文摘 | SIMPSON J H FISHER N R WILES P | 2004 | Estuarine Coastal and Shelf Science2004，60，4： | 1 |
| 10 | Role of Fe ( 111), phosphate, dissolved organic matter, and nitrate during the photodegradation of domoie acid in the marine environment 显示文摘 | FISHER J M REESE J G PELLECHIA P J | 2006 | Environ Sci Technol2006，40，7： | 1 |
| 11 | Charter value and Com- mercial Banks' Risk - taking in the NAFTA Countries 显示文摘 | Fisher K P Gueyie J P | 2001 | The International Journal of Fi- nance2001，，13： | 1 |
| 12 | VLIW processors:from blue sky to best buy显示文摘 | Fisher J A Faraboschi P Young C | 2009 | IEEE Solid-State Circuits Magazine2009，1，2： | 1 |
| 13 | Mouse mutant embryos overexpressing IGF-Ⅱ exhibit phenotypie features of the Beekwith-Wiedemann and Simpson-Golabi-Behmel syndromes显示文摘 | Eggenschwiler J Ludwig T Fisher P | 1997 | Genes Dev1997，11，23： | 1 |
| 14 | Subfractionation and characterization of mayart asphaltene显示文摘 | MILLER J T FISHER R B THIYAGARAJAN P | 1998 | Energy Fuels1998，12，6： | 1 |
| 15 | Survival and spread of the endophyte Stagonospora pteridiicola in Pteridium aquilinum, other ferns and some flowering plants 显示文摘 | P J Fisher | 1996 | New Phytologist1996，132，1： | 1 |
| 16 | Fatty acid hinging protein expression in different adipose tissue depots from lean and obese individuals显示文摘 | Fisher R M Eriksson P Hoffstedt J | 2001 | Diabetolo- gia2001，44，10： | 1 |
| 17 | Prognostic value of an RNA expression signature derived from ee cycle proliferation genes in patients with prostate cancer: a retrospective study显示文摘 | Cuzick J Swanson G P Fisher G Brothman A R Berney D M Reid J E | 2011 | Lancet Oncol2011，12，： | 1 |
| 18 | Experience with microarray based comparative genomic hybridization for pre- natal diagnosis in over 5000 pregnancies显示文摘 | Shaffer L G Dabell M P Fisher A J | 2012 | Prenat Diagn2012，32，10： | 1 |
| 19 | Obesity is an FGF21 resistant state 显示文摘 | FISHER F M CHUI P C ANTONELLIS P J | 2010 | Diabetes2010，59，11： | 1 |
| 20 | A comparative study of fungal endophytes in xylem and whole stem of Pinus sylves- tris and Fagus syIvatica 显示文摘 | Petrini O Fisher P J | 1988 | Trans Br Mycol Soc1988，91，2： | 1 |
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