|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Methane emission from rice fields as influenced by solar radiation, temperature, and straw incorporation显示文摘 | Sass R L Fisher F M Turner F T | 1991 | Global Biogeochemical Cycles1991，5，4： | 1 |
| 3 | Allelopathy: A Potential Cause pf Regeneration Failure 显示文摘 | Fisher R F | 1980 | Forestry1980，78，6： | 1 |
| 4 | Methane emissions from rice paddies: a process study summary 显示文摘 | Sass R L Fisher F M Jr | 1997 | Nutrient Cycling in Agroecosystems1997，49，13： | 1 |
| 5 | Characterization of mice deficient in aromatase (ArKO) be- cause of targeted disruption of the Cyp19 gene显示文摘 | Fisher C R Graves K H Parlow A F | 1998 | PNAS1998，95，： | 1 |
| 6 | Characterization of the hypoosmotically- induced Ca2 + response in primary astrocytes 显示文摘 | FISHER R SCHLIESS F | 1997 | Glia1997，20，： | 1 |
| 7 | Mitigation of methane emissions from rice fields: possible adverse effects of incorporated rice straw 显示文摘 | Sass R L Fisher F M Hareombe | 1991 | Global Biogeochemical Cycles1991，5，3： | 1 |
| 8 | Exchange ofmethane from rice fields:national,regional and global budgets 显示文摘 | Sass R L Fisher F M Ding A | 1999 | J Geophys Res1999，，26： | 1 |
| 9 | Longevity record for deep-sea invertebrate显示文摘 | BERGQUIST D C WILLIAMS F M FISHER C R | 2000 | Nature2000，403，： | 1 |
| 10 | Allelopathy:A potential cause of regeneration of failure显示文摘 | Fisher R F | | 0，，： | 1 |
| 11 | The force of contraction of the human ciliary muscle during accommodation显示文摘 | FISHER R F | 1977 | J Physiol1977，270，1： | 1 |
| 12 | Amino-functionalized carbon nanotubes for binding to polymers and biological systems显示文摘 | Ramanathan T Fisher F T Ruoff R S | 2005 | Chem Mater2005，17，： | 1 |
| 13 | Reinforcement mechanisms in MWNT-filled polyearbonate 显示文摘 | Eitan A Fisher F T Andrews R | 2006 | Compos Sci Technol2006，66，9： | 1 |
| 14 | Viscous shear as an agent for grain refinement in cast metal显示文摘 | Crossley F A Fisher R D Metcalfe A G | 1961 | Trans Metall Soc AIME1961，，221： | 1 |
| 15 | Enterovirus 2Apro targets MDA5and MAVS in infected cells显示文摘 | Feng Q Langereis M A Lork M Nguyen M Hato S V Lanke K Emdad L Bhoopathi P Fisher P B Lloyd R E van Kuppeveld F J | 2014 | J Virol2014，88，6： | 1 |
| 16 | Investigation Into the Interference Potential of Spread-Spectrum Clock Generation to Broadband Digital Communications显示文摘 | Hardin K Oglesbee R A Fisher F | 2003 | IEEE Trans on Electromagnetic Compatibility2003，45，1： | 1 |
| 17 | Opal phytoliths as an indicator of the foristies of prehistoric grasslands显示文摘 | Fisher R F Newell Bourne C Fisher W F | 1995 | Geo-derma1995，68，4： | 1 |
| 18 | Reduced peak-to-average power ratio of multicarrier modulation by selective Mapping显示文摘 | Baurnl R W Fisher R F H Huber J B | 1996 | Electronics Letters1996，32，22： | 1 |
| 19 | Fiber waviness in nanotube-reinforced polymer composites I: modulus predictions using effective nanotube properties 显示文摘 | Fisher F T Bradshawl R D Bfinson L C | 2003 | Composites Science and Technology2003，63，11： | 1 |
| 20 | Hypoxia inducible factor-1 upregulates adiponectin in diabetic mouse hearts and attenuates post-ischemie injury 显示文摘 | Natarajan R Salloum F Fisher B | 2008 | J Cardiovasc Pharmacol2008，51，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员