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| 1 | Long acting octreotide in the treatment of advanced hepatocellular cancer and overexpression of somatostatin receptors: Randomized placebo-controlled trial显示文摘AIM: To estimate if and to what extent long acting octreotide (LAR) improves survival and quality of life in patients with advanced hepatocellular carcinoma (HCC). METHODS: A total of 127 cirrhotics, stages A-B, due to chronic viral infections and with advanced HCC, were enrolled in the study. Scintigraphy with 111Indium labeled octreotide was performed in all cases. The patients with increased accumulation of radionuclear compound were randomized to receive either oral placebo only or octreotide/octreotide LAR only as follows: octreotide 0.5mg s.c. every 8 h for 6 wk, at the end of wk 4-8 octreotide LAR 20 mg i.m. and at the end of wk 12 and every 4 wk octreotide LAR 30mg i.m.. Follow-up was worked out monthly as well as the estimation of quality of life (QLQ-C30 questionnaire). Patients with negative somatostatin receptors (SSTR) detection were followed up in the same manner. RESULTS: Scintigraphy demonstrated SSTR in 61 patients. Thirty were randomized to receive only placebo and 31 only octreotide. A significantly higher survival time was observed for the octreotide group (49 ± 6 wk) as compared to the control group (28 ± 1 wk) and to the SSTR negative group (28 ± 2 wk), LR = 20.39, df = 2, P < 0.01. The octreotide group presented 68.5% lower hazard ratio [95% CI (47.4%-81.2%)]. During the f irst year, a 22%, 39% and 43% decrease in the QLQ-C30 score was observed in each group respectively.CONCLUSION: The proposed therapeutic approach has shown to improve the survival and quality of life in SSTR positive patients with advanced HCC. | D Dimitroulopoulos D Xinopoulos K Tsamakidis A Zisimopoulos E Andriotis D Panagiotakos A Fotopoulou C Chrysohoou A Bazinis D Daskalopoulou E Paraskevas | 2007 | World Journal of Gastroenterology2007，13，23： | 18 |
| 2 | Primary radical surgery in elderly patients With Epithelial Ovarian Cancer Analysis of Surgical Out-come and Long-Term Survival显示文摘 | Fotopoulou C Savvatis K | 2010 | Int J Gynecol Cancer2010，20，1： | 1 |
| 3 | Venous thromboembolism in recurrent ovarian cancer-patients: a systematic evaluation of the North-Eastern German Society of Gynaecologic Oncology Ovarian Cancer Study Group ( NOGGO ) 显示文摘 | Fotopoulou C Karavas A Trappe R | 2009 | Thromb Res2009，124，5： | 1 |
| 4 | Evidence-based perioperative management:strategic shifts in times of fast track surgery显示文摘 | Chopra SS Schmidt SC Fotopoulou C | 2009 | Anticancer Res2009，29，7： | 1 |
| 5 | A randomized phase m adjuvant study in high-risk cervical cancer: simultane- ous radiochemotherapy with cisplatin ( S-RC ) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R) : a NOGGO-AGO Intergroup Study 显示文摘 | Sehouli J Runnebaum IB Fotopoulou C | 2012 | Ann Oncol2012，23，： | 1 |
| 6 | Primary radical surgery in elderly patients with epithelial ovarian cancer analysis of surgical out come and long-term survival显示文摘 | Fotopoulou C Savvatis K | 2010 | Int J Gynecol Cancer2010，20，1： | 1 |
| 7 | Long-term clinical outcome of pelvic exenteration in patients with advanced gy necological malignaneies显示文摘 | Fotopoulou C Neumann U Kraetschell R | 2010 | J Surg Oncol2010，101，6： | 1 |
| 8 | Long-term effects of neovaginal reconstruction with sigmoid loop technique on sexual function and self image in patients with gynecologic malignancies:results of a prospective study显示文摘 | FOTOPOULOU C NEUMANN U KLAPP C | 2008 | Gynecol Oncol2008，111，3： | 1 |
| 9 | Serum glycome profiling:a biomarker for diagnosis of ovarian cancer显示文摘 | Biskup K Braicu EI Sehouli J Fotopoulou C Tauber R Berger M | 2013 | J Proteome Res2013，12，9： | 1 |
| 10 | Mid-trimester amniotic fluid concentrations of the proinflammatory cytokines IL-6, IL-8, TNF-, and lipopolysaccharide binding protein in normal pregnancies : a prospective evaluation according to parity, gestational age, and fetal gender 显示文摘 | Bamberg C Fotopoulou C Linder M | 2011 | J Perinat Med2011，39，4： | 1 |
| 11 | Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period显示文摘 | Fotopoulou C Kretz R Bauer S | 2009 | Epilepsy Res2009，85，1： | 1 |
| 12 | Empathy from Others Influence My Pain显示文摘 | Sambo C Fotopoulou K | | 0，，： | 1 |
| 13 | Post - column terbium complexation and sensitized fluorescence detection for the determination of norepinephrine, epinephrine and dopamine using high- performance liquid chromatography显示文摘 | Maria A Fotopoulou Penelope C Ioannou | 2002 | Analytica Chimica Acta2002，462，2： | 1 |
| 14 | Functional and anatomic results of amnion vaginoplasty in young women with Mayer- Rokitansky - Ktlster - Hauser syndrome 显示文摘 | Fotopoulou C Sehouli J Gehrmann N | 2010 | Fertil Steril2010，94，1： | 1 |
| 15 | Clinical outcome of tertiary surgical cytoreduetion in patients with recurrent epithelial ovarian cancer显示文摘 | Fotopoulou C Richter R Braieu IE | 2011 | Ann Surg Oncol2011，18，1： | 1 |
| 16 | Evidence-based perioper- ative management : strategic shifts in times of fast track surgery显示文摘 | Chopra SS Schmidt SC Fotopoulou C | 2009 | Anticancer Res2009，29，7： | 1 |
| 17 | Value of tertiary cytoreduc- tive surgery in epithelial ovarian cancer:an international muhicenter evaluation显示文摘 | Fotopoulou C Zang R Gultekin M | 2013 | Ann Surg Oncol2013，20，4： | 1 |
| 18 | Maternalcharacteristics and twingestation outcomes over 10 years: Impact of conception methods显示文摘 | Bamberg C Fotopoulou C Neissner P | 2012 | Fertil Steri12012，98，1： | 1 |
| 19 | Post-column terbium complexation and sensitized fluorescence detection for the determination of norepinephrine,epinephrine and dopamine using high-performance liquid chromatography显示文摘 | Ioarmou P C | 2002 | Anal Chim Acta2002，462，2： | 1 |
| 20 | Quaternary cytoreductive surgery in ovarian cancer:does surgical effort still matter? 显示文摘 | Fotopoulou C Sawatis K Kosian P | 2013 | Br J Cancer2013，108，1： | 1 |
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