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| 1 | Model for end-stage liver disease score versus Child score in predicting the outcome of surgical procedures in patients with cirrhosis显示文摘AIM:To determine factors affecting the outcome of patients with cirrhosis undergoing surgery and to compare the capacities of the Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD)score to predict that outcome. METHODS:We reviewed the charts of 195 patients with cirrhosis who underwent surgery at two teaching hospitals over a five-year period.The combined endpoint of death or hepatic decompensation was considered to be the primary endpoint. RESULTS:Patients who reached the endpoint had a higher MELD score,a higher CTP score and were more likely to have undergone an urgent procedure.Among patients undergoing elective surgical procedures,no statistically significant difference was noted in the mean MELD(12.8±3.9 vs 12.6±4.7,P=0.9)or in the mean CTP(7.6±1.2 vs 7.7±1.7,P=0.8)between patients who reached the endpoint and those who did not.Both mean scores were higher in the patients reaching the endpoint in the case of urgent procedures(MELD:22.4± 8.7 vs 15.2±6.4,P=0.0007;CTP:9.9±1.8 vs 8.5±1.8, P=0.008).The performances of the MELD and CTP scores in predicting the outcome of urgent surgery were only fair,without a significant difference between them (AUC=0.755±0.066 for MELD vs AUC=0.696±0.070 for CTP,P=0.3). CONCLUSION:The CTP and MELD scores performedequally,but only fairly in predicting the outcome of urgent surgical procedures.Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with cirrhosis. | Maarouf A Hoteit Amaar H Ghazale Andrew J Bain Eli S Rosenberg Kirk A Easley Frank A Anania Robin E Rutherford | 2008 | World Journal of Gastroenterology2008，14，11： | 16 |
| 2 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 5 | Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages显示文摘 | Wilson B A Smith V H Frank D J R | 2003 | Environ Sci Technol2003，37，9： | 1 |
| 6 | Esomeprazole reduces gastroe- sophageal reflux after beer consumption in healthy volunteers 显示文摘 | Franke A Hepp C Harder H | 2008 | Seand J Gastroenterol2008，43，12： | 1 |
| 7 | Measurements and correlations of the physical of CO_Wheavy crude oil mixtures显示文摘 | Chung Frank T H Jones Ray A Nguyen Hai T | 1988 | SPE Reservoir Engi- neering1988，40，8： | 1 |
| 8 | Choree and change of measures in performance measurement modals显示文摘 | Mary A M Frank H S | 2004 | Management Accounting Research2004，15，： | 1 |
| 9 | Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specifl 16S rRNA-targeted oligonucleotide probes显示文摘 | FRANKS A HARMSEN H J M RAANGS G | 1998 | Applied and Environmental Microbiology1998，64，9： | 1 |
| 10 | Improving Vehicle Fuel Economy with Hybrid Power System显示文摘 | NORMAN B FRANK H ANDREW A | 1978 | SAE Paper1978，，： | 1 |
| 11 | Meth - ods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging 显示文摘 | FRANK J A ANDERSON S A KALSIH H | 2004 | Cytotherapy2004，6，6： | 1 |
| 12 | Carotenoids in Photosynthesis 显示文摘 | Frank H A Cogdell R J | 1996 | Photochemistry and Photobiology1996，63，3： | 1 |
| 13 | Nitrogen fertili- zation timing effect on wheat production, nitrogen uptake efficiency,and residual soil nitrogen显示文摘 | Mercedes M A Frank M H Vincont A H | 1993 | Agron J1993，85，： | 1 |
| 14 | Cell culture models of human trophoblast Ⅱ: Trophoblast cell lines-α workshop report显示文摘 | Shiverick KT King A Frank H | 2001 | Placenta2001，22，： | 1 |
| 15 | Nitrogen fertili- zation timing effect on wheat production, nitrogen uptake efficiency, and residual soil 显示文摘 | Mercedes M A Frank M H Vincont A H | 1993 | Nitrogen Agron J1993，85，： | 1 |
| 16 | Anaerobic threshold alterations caused by endurance training in middle aged men显示文摘 | DAVIS J A FRANK M H WHIPP B J | 1979 | J Appl Physiol1979，46，6： | 1 |
| 17 | Quantitative Determination of Perfluorinated Surfactants in Water by LC-ESI-MS! MS显示文摘 | Weremiuk A M Gerstmann S Frank H | 2006 | J Sep Sci2006，29，： | 1 |
| 18 | Design, demonstrations andsustainability impact assessments for plug-in hybridelectric vehicles显示文摘 | Bradley T H Frank A A | 2009 | Renewable and Sustainable EnergyReviews2009，13，1： | 1 |
| 19 | Computer simulation of local order in condensed phases of silicon显示文摘 | Frank H Stillinger Thomas A Weber | | 0，，： | 1 |
| 20 | Temperature and mixing field measurements in stratified lean premixed turbulent flames 显示文摘 | Bohm B Frank J H Dreizler A | 2011 | Proceedings of the Combustion Institute2011，33，： | 1 |
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