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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | E6 molecular variants of human papillomavirus (HPV) type 16: An updated and unified criterion for clustering and nomenclature显示文摘 | Antonio Huertas-Salgado Diana C. Martín-Gámez Pablo Moreno Raúl Murillo María Mercedes Bravo Luisa Villa Mónica Molano | 2010 | Virology2010，，： | 2 |
| 5 | Nitrogen fertili- zation timing effect on wheat production, nitrogen uptake efficiency,and residual soil nitrogen显示文摘 | Mercedes M A Frank M H Vincont A H | 1993 | Agron J1993，85，： | 1 |
| 6 | Nitrogen fertili- zation timing effect on wheat production, nitrogen uptake efficiency, and residual soil 显示文摘 | Mercedes M A Frank M H Vincont A H | 1993 | Nitrogen Agron J1993，85，： | 1 |
| 7 | Integrated biodiesel production: A comparison of different homogeneous catalysts systems 显示文摘 | Gemma V Mercedes M Jose A | 2004 | BioresourceTechnology2004，92，3： | 1 |
| 8 | Residues of organochlorine pesticides in soils from the southern Sonora, Mexico显示文摘 | Cantu E U Mercedes M M Valenzuela A I | 2011 | Bulletin of Environmental Contamination and Toxicology2011，87，5： | 1 |
| 9 | Synthesis and characterization of a new gemini suffactant derived from 3α, 12α -di- hydroxy - 58 - cholan - 24 - amine ( steroid residue) and ethylenedi- amintetraacetic acid (spacer) 显示文摘 | MERCEDES A A AIDA J FRANCISCO M | 2008 | Langmuir2008，24，： | 1 |
| 10 | Treatment of a styrene-butadiene-styrene rubber with corona discharge to improve the adhesion to polyurethane adhesive显示文摘 | María D Romero-Sánchez M Mercedes Pastor-Blas an José Miguel Martín-Martínez | 2003 | International Journal of Adhesion and Adhesives2003，23，1： | 1 |
| 11 | Integrated biodiesel production: a comparison of different homogeneous catalyst systems 显示文摘 | Vicente G Mercedes M Jose A | 2004 | Bioresouce Technology2004，92，3： | 1 |
| 12 | Optimization of brassica carinata oil methanolysis for biodiesel production 显示文摘 | GEMMA V MERCEDES M JOS A | 2005 | Journal of American Oil Chemists''Society2005，82，： | 1 |
| 13 | Pilot interferon-β trial in children with chronic hepatitis B who had previously not responded to interferon-α therapy显示文摘 | Mercedes R M Patriciafernanedez A Ana L | 1997 | Pediatrics1997，99，2： | 1 |
| 14 | Optimization of brassica carinata oil methanolysis for biodiesel production显示文摘 | Gemma V Mercedes M Jos A | 2005 | Journal of American Oil Chemists'' Society2005，82，： | 1 |
| 15 | Calcium carbonate precipitation by heterotrophic bacteria isolated from biofilms formed on deteriorated ignimbrite stones: influence of calcium on EPS production and biofilm formation by these isolates 显示文摘 | Lopez-Moreno A Sepulveda-Sanchez J D Mercedes Alonso Guzman E M | 2014 | Biofouling2014，30，： | 1 |
| 16 | Analysis of Acetamiprid in Vegetables Using Gas Chromatography-Tandem Mass Spectrometry显示文摘 | MANUEL M-S MERCEDES M F JAVIER A | 2003 | Analytical Sciences2003，19，5： | 1 |
| 17 | Integrated biodiesel production : A comparison of different homogeneous catalysts systems 显示文摘 | Gemma V Mercedes M Jose A | 2004 | Bioresource Technology2004，92，3： | 1 |
| 18 | Accumulation of very - long - chain fatty acids in membrane glycerolipids is associated with dramatic aAlterations in plant morphology显示文摘 | Anthony A M Mercedes W Ljerka K | 1998 | Plant Cell1998，10，： | 1 |
| 19 | Photophysics of fluorene copolymers containing 1,3,4-oxadiazole or 1,3,4-oxadiazole and carbazole units显示文摘 | MAYKEL D M MERCEDES A | 2010 | J Phys Chem C2010，114，14： | 1 |
| 20 | The Bacillus subtilis 168 csn gene encodes a chitosanase with similar properties to a Streptomyces enzyme显示文摘 | Rivas L A Parro V Mercedes M P | 2000 | Microbiology2000，146，： | 1 |
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