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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Fluctuations in Pre- cambrian atmospheric oxygenation recorded by chromium iso- topes显示文摘 | Frei R Gaucher C Poulton S W | 2009 | Nature2009，461，： | 1 |
| 4 | Bacterial and Fungal Contributions to Carbon Sequestration in Agroecosystems 显示文摘 | SIX J FREY S D THIET R K | 2006 | Soil Biology and Biochemistry2006，70，： | 1 |
| 5 | Bacterial and fungal contributions to carbon sequestration in agroecosystems显示文摘 | Six J Frey S D Thiet R K | 2006 | Soil Science Society of America Journal2006，70，2： | 1 |
| 6 | Surface-medi- ated release of a small-molecule modulator of bacterial biofilm formation: a non-Bactericidal approach to inhibi- ting biofilm formation in pseudomonas aeruginosa 显示文摘 | Broderick A H Breitbach A S Frei R | 2013 | Adv Healthc Mater2013，2，7： | 1 |
| 7 | A perinucleolar compartment contains several RNA polymerase Ⅲ transcripts as well as the polypyrirnidine tract - binding protein, hnRNP I 显示文摘 | Matera A G Frey M R Margelot K Wolin S L | 1995 | J Cell Biol1995，129，： | 1 |
| 8 | Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells 显示文摘 | Meister S Frey B Lang V R | 2010 | Neoplasia2010，12，7： | 1 |
| 9 | Intranasal delivery of neurotrophic factors BDNF,CNTF,EPO,and NT-4 to the CNS显示文摘 | Alcalá-Barraza S R Lee M S Hanson L R McDonald A A Frey W H 2nd McLoon L K | | 0，，： | 1 |
| 10 | Appendicitis outcomes with increasing computed tomographic scanning 显示文摘 | Frei S P Bond W F Bazuro R K | 2008 | Am J Emerg Med2008，26，1： | 1 |
| 11 | Pitfalls and new approaches in granulite chronometry: An example from the Limpopo Belt,Zimbabwe显示文摘 | Kamber B S Frei R Gibb A J | 1998 | Precambrian Research1998，91，： | 1 |
| 12 | Bone morphogenetic proteins in clinical applications显示文摘 | Gautschi O P Frey S P Zellweger R | | 0，，08： | 1 |
| 13 | Accelerated aging tests of chromium containing amorphous hydrogenated carbon coatings for solar collectors 显示文摘 | GAMPP R OELHAFEN P GANTENBEIN P BRUNOLD S FREI U | 1998 | Sol Energy Mat Sol C1998，54，： | 1 |
| 14 | PTIC/87/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vas- cular endothelial growth factor-induced responses and tumor growth after oral administration 显示文摘 | Wood JM Bold G Buchdtmger E Cozens R Ferrari S Frei J | 2000 | Cancer Res2000，60，8： | 1 |
| 15 | Intranasal delivery to the central nervous system:mechanisms and experimental considerations显示文摘 | Dhuria S V Hanson L R Frey W H 2nd | | 0，，04： | 1 |
| 16 | Quantification of metabolic differences in the frontal brain of depressive pa- tients and controls obtained by 1H-MRS at 3 Tesla显示文摘 | Gruber S Frey R Mlynarik V | 2003 | Invest Radiol2003，38，7： | 1 |
| 17 | Effect of Meloidogyne incognita inoculum density and application rate of Paecilomyces lilacinus strain 251 on biocontrol efficacy and colonization of egg masses analyzed by real-time quantitative PCR显示文摘 | Kiewnick S Neumann S Sikora R A Frey J E | 2011 | Phytopathology2011，101，1： | 1 |
| 18 | Bacterial and fungal contributions to carbon sequestration in agroecosystems显示文摘 | SIX J FREY S D THIET R K | 2006 | Soil Science Society of America Journal2006，70，： | 1 |
| 19 | Quality of life in long-term childhood cancer survivors and the relation of late effects and subjective well-being显示文摘 | PEMBERGER S JAGSCH R FREY E | 2005 | Support Care Cancer2005，13，1： | 1 |
| 20 | Trace fossil nomencla- ture and the Plarolites-Palaeophycus dilemma显示文摘 | Pemberton S G Frey R W | 1982 | Journal of Paleontology1982，56，： | 1 |
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