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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Acute stress facilitates long-lasting changes in chrolinergic gene expression显示文摘 | Kaufer D Friedman A Seidman S | 1998 | Nature1998，393，6683： | 1 |
| 3 | Inhibition of the HIV-1 Protease by Fullerene Derivatives: Model Building Studies and Experimental Verification显示文摘 | Friedman S H DeCamp D L Sijbesma R P etc | 1993 | J Am Chem Soc1993，115，： | 1 |
| 4 | The anticariogenic effect of amine fluorides on streptococcus sobrinus and glucosyhransferase in biofilms 显示文摘 | Sharti S Friedman M Steinberg D | 2000 | Caries Res2000，34，3： | 1 |
| 5 | Important causes of visual impairment in the world today显示文摘 | Congdon N G Friedman D S Lietman T | 2003 | JAMA2003，290，15： | 1 |
| 6 | Pneumonia with serological evidence of acute infection with the Chlamydia-like microorganism 'Z'显示文摘 | Kahane S Friedman MG | 1997 | Am J Respir Crit Care Med1997，156，： | 1 |
| 7 | Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry显示文摘 | Friedman D B Hill S Keller J W | 2004 | Proteomics2004，4，3： | 1 |
| 8 | Observation of brittledeformation features at the maximum stress of westerly granite and Solnhofen limestone显示文摘 | Friedman M Perkins R D Green S J | 1970 | International Journal of Rock Mechanics and Mining Sciences1970，7，3： | 1 |
| 9 | Angiomyoli- Ioma: computed tomographic-pathologie correlation of 17 cases 显示文摘 | Sherman J L Hartman D S Friedman A C | 1981 | AJR1981，37，6： | 1 |
| 10 | Validation of a polymerase chain reaction method for the detection of rendered bovine-derived materials in feedstuffs 显示文摘 | Myers M J Friedman S L Farrell D E | 2001 | J Food Prot2001，64，4： | 1 |
| 11 | Withering syndrome in farmed red abalone Haliotis rufescens :thermal induction andassociation with a gastrointestinal Rickettsiales-hke prokaryote显示文摘 | MOORE J D ROBBINS T T FRIEDMAN C S | 2000 | Aquat Anim Health2000，12，： | 1 |
| 12 | Superparamagnetic photonic crystals显示文摘 | Xu X L Friedman G Humfeld K D Majetich S A Asher S A | 2001 | Adv Mater2001，13，： | 1 |
| 13 | Stress myocardial perfusion single-photon emission computed tomography is clinically effective and cost effective in risk stratification of patients with a high likelihood of coronary artery disease (CAD) but no known CAD显示文摘 | Hachamovitch R Hayes S W Friedman J D | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 14 | All about DIGE: quantification echnology for differential - display 2D - gel proteomics显示文摘 | Lilley K S Friedman D B | 2004 | Expert Rev Proteomics2004，1，4： | 1 |
| 15 | 1-eV solar cells with GaInNAs active layer 显示文摘 | Friedman D J Geisz J F Kurtz S R | 1998 | J Cryst Growth1998，195，： | 1 |
| 16 | 1-eV solar cellswith GalnNAs active layer 显示文摘 | FRIEDMAN D J GEISZ J F KURTZ S R | 1998 | Journal of Crystal Growth1998，195，14： | 1 |
| 17 | High-speed Integrated Nanowire Circuits显示文摘 | FRIEDMAN R S MCALPINE M C RICKETTS D S | 2005 | Nature2005，434，： | 1 |
| 18 | The search for BRCA1显示文摘 | Friedman L S Ostermeyer E A Lynch E D | 1994 | Cancer Res1994，54，24： | 1 |
| 19 | 1-eV Solar Cells with GaInNAs Active Layer 显示文摘 | Friedman D J Geisz J F Kurtz S R etal | 1998 | Journal of Crystal Growth1998，195，： | 1 |
| 20 | Hepatic fibrosis 2006:report of the Third AASLD Single Topic Conference 显示文摘 | Friedman S L Rockey D C Bissell D M | 2007 | Hepatology2007，45，1： | 1 |
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