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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | A four-channel,low-power CMOS charge preamplifier for silicon detectors with medium value of capacitance显示文摘 | RANDAZZO N RUSSO G V PRESTI D L | 1997 | IEEE Transactions on Nuclear Science1997，44，1： | 1 |
| 3 | Diversity,dynamics,and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | Randazzo C L Torriani S Antoon D L | 2002 | Appl Environ Microbiol2002，68，4： | 1 |
| 4 | Role of surfactants in optimizing fluoreue assimilation and intermediate formation by rhodochrous VKMB-2469 显示文摘 | KOLOMYTSEVA M P RANDAZZO D BASKUNOV B P | 2009 | Bioresource Technology2009，100，： | 1 |
| 5 | Arf GAPs: multifunctional proteins thatregulate membrane traffic and actin remodelling 显示文摘 | Randazzo P A Hirsch D S | 2004 | Cell Signal2004，16，4： | 1 |
| 6 | Diversity,dynamics,and activity of bacterial communities during production of anartisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | RANDAZZO C L TORRIANI S AKKERMANS A D L at el | 2002 | ApplEnviron Microbiol2002，68，4： | 1 |
| 7 | Lactobacillus casei, dominant species in naturally fermented Sicilian green olives显示文摘 | Randazzo C L Restuccia C Romano A D | 2004 | Int Food nicrobiol2004，90，1： | 1 |
| 8 | Diversity , dynamics and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | Randazzo C L Torriani S Akkermans A D L | 2002 | Applied and Environmental Microbiology2002，68，4： | 1 |
| 9 | Diversity, dynamics and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | Randazzo C L Torriani S Akkermans A D L | 2002 | Appl Environ Microbiol2002，68，： | 1 |
| 10 | Oxiracetam treatment of exogenous post-concussion syndrome:statistical evaluation of results 显示文摘 | Russello D Randazzo G Favetta A | 1990 | Minerva Chir1990，45，20： | 1 |
| 11 | Axinellis A and B: New praline-containing antiproliferative cyclopeptides from the vanuatu sponge Axinella carteri显示文摘 | RANDAZZO A PIAZ F D ORRU S | 1998 | Eur J Org Chem1998，11，6： | 1 |
| 12 | Diversity,dynarnics and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | RANDAZZO C L TORRIANI S AKKERMANS A D L | 2002 | Applied and Envrionmental Microbiology2002，68，： | 1 |
| 13 | Diversity,dynamics and activity of bacterialcommunities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | Randazzo C L Torriani S Akkermans A D L de Vos W M Vaughan E E | 2002 | Appl Environ Microbiol2002，68，： | 1 |
| 14 | Diversity, dynamics, and activity of bacterial communities during production of an artisanal sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | RANDAZZO C L TORRIANI S AKKERMANS A D L | 2002 | Appfied and Environmental Microbiology2002，68，4： | 1 |
| 15 | Diversity,dynamics,and activity of bacterial communities during production of an artisanal sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | Randazzo C L Torriani S Akkermans A D L | 2000 | Appl Environ Microbiol2000，68，： | 1 |
| 16 | Diver- sity, dynamics and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis 显示文摘 | Randazzo C L Torriani S Akkermans A D L | 2002 | Appl Environ Microbiol2002，68，4： | 1 |
| 17 | Diversity,dynamics and activity of bacterial communities during production of an artisanal Sicilian cheese as evaluated by 16S rRNA analysis显示文摘 | RANDAZZO C L TORRIANI S AKKERMANS A D L | 2002 | Appl Environ Microbiol2002，68，： | 1 |
| 18 | Structural revision of halipeptins, Synthesis of the thiazoline unit and isolation of halipeptinc显示文摘 | MONICA C D RANDAZZO A BIFULCO G | 2002 | Tetrahedron Letters2002，43，： | 1 |
| 19 | A Brgl null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes显示文摘 | Bultman S Gebuhr T Yee D La Mantia C Nicholson J Gilliam A Randazzo F Metzg | | 0，，06： | 1 |
| 20 | Oxiracetam treatemet of exogenous postconcussion syndrome statisticale valuation of results显示文摘 | Russello D Randazzo G Favetta A | 1990 | Minerva Chir1990，45，20： | 1 |
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