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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Association between duplex Doppler sonographic flow pattern in right hepatic vein and various liver diseases显示文摘 | Von Herbay A Frieling T Haussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 3 | Association between du- plex Doppler sonographic flow pattern in right hepatic vein and va- rious liver diseases 显示文摘 | van Herbay A Frieling T Haussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 4 | A genetic as- sociation study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM) 显示文摘 | Romero R Friel L A Velez D R | 2010 | Am J Obstet Gynecol2010，5，26： | 1 |
| 5 | Association between duplex Doppler soncgraphic flow pattern in right hepatic vein and various liver diseases显示文摘 | Von Herhay A Frieling T Haussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 6 | Oligonucleotide microarray analysis of gene expression in follicle-stimulating hormone-treated rat Sertoli cells显示文摘 | McLean D J Friel P J Pouchnik D | 2002 | Molecular Endocrinology2002，16，： | 1 |
| 7 | Color Doppler sono- graphic evaluation of spontaneous portosystemic shunts and in- version of portal venous flow in patients with cirrhosis显示文摘 | Von Herbay A Frieling T Haussinger D | 2000 | J Clin Ultrasound2000，28，7： | 1 |
| 8 | Color Doppler sonographic evaluation of spontaneous portosystemic shunts and inversion of portal venous flow in patients with cirrhosis 显示文摘 | von HERBAY A FRIELING T HAUSSINGER D | 2000 | J Clin Ultrasound2000，28，7： | 1 |
| 9 | i oscillations in sympathetic neurons: an experimental test of a theoretical model显示文摘 | Friel D D | 1995 | Biophys J1995，68，5： | 1 |
| 10 | Association between duplex Doppler sonographie flow pattern in fight hepatic vein and various liver diseases显示文摘 | Yon Herbay A Frieling T Haussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 11 | Association between duplex Doppler sonographic flow pattern in right hepatic vein and various liver diseases显示文摘 | Von Herbay AV Frieling T Haussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 12 | Mitochondria as regulators of stimulus-evoked calcium signals in neurons显示文摘 | Friel D D | 2000 | Cell Calcium2000，28，： | 1 |
| 13 | Calcium dynamics:analyzing the Ca2+ re-gulatory network in intact cells显示文摘 | Friel D D Chiel H J | 2008 | Trends Neurosci2008，31，1： | 1 |
| 14 | Measurement and compensation of digital-to-analog converter nonlinearity显示文摘 | Friel G A Hummels D M Irons F H | 2002 | Measurement2002，31，3： | 1 |
| 15 | Oligonucleotide microarray analysis of gene expression in follicle-stimulating hormone-treated rat Sertoli cells显示文摘 | Friel PJ Pouchnik D | 2002 | Mol Endocrinol2002，16，12： | 1 |
| 16 | Association between duplex Doppler sonographic flow pattern in right hepatic vein and various liver diseases显示文摘 | Von Herbay A Frieling T Haussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 17 | Depressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders显示文摘 | Frieling H Romer K D Beyer S | 2006 | Psychiatr Res2006，18，： | 1 |
| 18 | Association between duplex Doppler sonographic flow pattern in right hepatic vein and various liver diseases显示文摘 | Herbay AV Frieling T Hussinger D | 2001 | J Clin Ultrasound2001，29，1： | 1 |
| 19 | Nonoperative treatment of symptomatic spondylolysis 显示文摘 | Kurd M F Patel D Norton R Picetti G Friel B Vaccaro A R | 2007 | J Spinal Disord Tech2007，20，： | 1 |
| 20 | Global DNA hypomethylation and DNA hypermethylation of the alpha synuclein promoter in females with anorexia nervosa 显示文摘 | Frieling H Gozner A Romer K D | 2007 | Mol Psychiatr2007，12，3： | 1 |
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