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| 1 | An impact angle constraint integral sliding mode guidance law for maneuvering targets interception显示文摘An integral sliding mode guidance law(ISMGL)combined with the advantages of the integral sliding mode control(SMC)method is designed to address maneuvering target interception problems with impact angle constraints.The relative motion equation of the missile and the target considering the impact angle constraint is established in the longitudinal plane,and an integral sliding mode surface is constructed.The proposed guidance law resolves the existence of a steady-state error problem in the traditional SMC.Such a guidance law ensures that the missile hits the target with an ideal impact angle in finite time and the missile is kept highly robust throughout the interception process.By adopting the dynamic surface control method,the ISMGL is designed considering the impact angle constraints and the autopilot dynamic characteristics.According to the Lyapunov stability theorem,all states of the closed-loop system are finally proven to be uniformly bounded.Simulation results are compared with the general sliding mode guidance law and the trajectory shaping guidance law,and the findings verify the effectiveness and superiority of the ISMGL. | ZHANG Wenjie FU Shengnan LI Wei XIA Qunli | 2020 | Journal of Systems Engineering and Electronics2020，31，1： | 10 |
| 2 | Multiconstraint adaptive three-dimensional guidance law using convex optimization显示文摘The traditional guidance law only guarantees the accuracy of attacking a target. However, the look angle and acceleration constraints are indispensable in applications. A new adaptive three-dimensional proportional navigation(PN) guidance law is proposed based on convex optimization. Decomposition of the three-dimensional space is carried out to establish threedimensional kinematic engagements. The constraints and the performance index are disposed by using the convex optimization method. PN guidance gains can be obtained by solving the optimization problem. This solution is more rapid and programmatic than the traditional method and provides a foundation for future online guidance methods, which is of great value for engineering applications. | FU Shengnan LIU Xiaodong ZHANG Wenjie XIA Qunli | 2020 | Journal of Systems Engineering and Electronics2020，31，4： | 3 |
| 3 | Analysis of the Relationship between the Cloud Water Path and Precipitation Intensity of Mature Typhoons in the Northwest Pacific Ocean显示文摘The relationship between precipitation intensity and cloud water in typhoon systems remains unclear.This study combined time-and space-synchronized precipitation and spectral data obtained by the Precipitation Radar(PR)as well as the Visible and Infrared Scanner(VIRS)onboard the TRMM satellite,to overcome the limitations of precipitation properties and cloud parameters not being synchronized in previous studies.A merged dataset of near-surface rain rate(RR)and corresponding cloud water path(CWP)was established and used to analyze the potential correlation between cloud microphysical properties and precipitation,to deepen our understanding of the evolution of cloud to rain.In addition,25 collocated satellite overpasses of mature typhoon cases in the Northwest Pacific Ocean from 1998 to 2012 were obtained,and the relationships between the CWP and RR of 144515 pixels were analyzed in detail.The results show that the CWP and RR of mature typhoon systems with different precipitation types,precipitation cloud phases,and vertical depths of precipitation can be fitted by a notable sigmoid function,which may be useful for estimating CWP and parameterizing precipitation in models.Furthermore,the relationship was applied and tested with an independent sample to show that RR is a significant indicator of CWP. | Shuang LUO Yunfei FU Shengnan ZHOU Xiaofeng WANG Dongyong WANG | 2020 | Advances in Atmospheric Sciences2020，37，4： | 2 |
| 4 | Trajectory optimization of a reentry vehicle based on artificial emotion memory optimization显示文摘The trajectory optimization of an unpowered reentry vehicle via artificial emotion memory optimization(AEMO)is discussed.Firstly,reentry dynamics are established based on multiple constraints and parameterized control variables with finite dimensions are designed.If the constraint is not satisfied,a distance measure and an adaptive penalty function are used to address this scenario.Secondly,AEMO is introduced to solve the trajectory optimization problem.Based on the theories of biology and cognition,the trial solutions based on emotional memory are established.Three search strategies are designed for realizing the random search of trial solutions and for avoiding becoming trapped in a local minimum.The states of the trial solutions are determined according to the rules of memory enhancement and forgetting.As the iterations proceed,the trial solutions with poor quality will gradually be forgotten.Therefore,the number of trial solutions is decreased,and the convergence of the algorithm is accelerated.Finally,a numerical simulation is conducted,and the results demonstrate that the path and terminal constraints are satisfied and the method can realize satisfactory performance. | FU Shengnan WANG Liang XIA Qunli | 2021 | Journal of Systems Engineering and Electronics2021，32，3： | 2 |
| 5 | A trajectory shaping guidance law with field-of-view angle constraint and terminal limits显示文摘In this paper, a trajectory shaping guidance law,which considers constraints of field-of-view(FOV) angle, impact angle, and terminal lateral acceleration, is proposed for a constant speed missile against a stationary target. First, to decouple constraints of the FOV angle and the terminal lateral acceleration, the third-order polynomial with respect to the line-ofsight(LOS) angle is introduced. Based on an analysis of the relationship between the looking angle and the guidance coefficient,the boundary of the coefficient that satisfies the FOV constraint is obtained. The terminal guidance law coefficient is used to guarantee the convergence of the terminal conditions. Furthermore, the proposed law can be implemented under bearingsonly information, as the guidance command does not involve the relative range and the LOS angle rate. Finally, numerical simulations are performed based on a kinematic vehicle model to verify the effectiveness of the guidance law. Overall, the work offers an easily implementable guidance law with closed-form guidance gains, which is suitable for engineering applications. | FU Shengnan ZHOU Guanqun XIA Qunli | 2022 | Journal of Systems Engineering and Electronics2022，33，2： | 2 |
| 6 | MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1显示文摘Unhealable diabetic wounds need to be addressed with the help of newer,more efficacious strategies.Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment.Here,the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch(SFP)were demonstrated to promote diabetic wound healing.Silk fibroin binding peptide(SFBP)was screened through phage display,and SFBP-Gluc-MS2(SGM)and pac-miR146a-pac fusion protein were constructed.The designed exosomes(SGM-Exos,miR146a-Exos,and SGM-miR146a-Exos)were isolated from the engineered placental mesenchymal stem cells(PMSCs)transduced with SGM or/and pac-miR146a-pac protein.Gluc signals indicated SGM-Exo@SFP markedly increased the binding rate and the stability of SGM-Exo.Moreover,the loading efficiency of miR146a in SGM-miR146a-Exos was ten-fold higher than that in miR146a-Exos.Superior to untreated,SGM-miR146a-Exo-only treated,and SFP-only treated groups,SGM-miR146a-Exo@SFP drived wound healing associated with less inflammation,collagen deposition,and neovascularization.The transcriptomics analysis suggested anti-inflammatory and regenerative effects with SGM-miR146a-Exo@SFP treatment.Here,we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. | Qiankun Li Wenzhi Hu Qilin Huang Jie Yang Bingmin Li Kui Ma Qian Wei Yaxi Wang Jianlong Su Mengli Sun Shengnan Cui Rungong Yang Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 7 | A protein-enabled protective film with functions of self-adapting and anion-anchoring for stabilizing lithium-metal batteries显示文摘Practical implementations of rechargeable lithium(Li)metal batteries have long been plagued by multiple problems of Li anode,such as Li dendrite growth,large volume change,low Coulombic efficiency.Here,we report a protein-enabled film that can provide effective protection for Li metal.The protective film with an integrated design of high flexibility,strong adhesion and high Li-ion transference number(0.80)is fabricated by incorporating denatured zein(corn protein)with polyethylene oxide(PEO)acting as an age nt for sustaining the denatured protein chains against refolding via the intermolecular interactions between them.Thus,a conformable zein-enabled protective film(zein@PEO)with simultaneous en hancement in flexibility,modulus and adhesion strength is gen erated to offer both functi ons of self-adapting and anion-anchoring abilities.The results show that the zein@PEO film is able to accommodate the volume change,reduce the side reactions,and homogenize the ion deposition.Benefiting from these significant properties/fu nctions,the Li/Cu cell with the zein@PEO film delivers prolonged cycle life for over 500 hours with stable performance.Paired with LiMn_(2)O_(4) cathode,the capacity,cycle stability and rate performance of the cell are remarkably improved as well,demonstrati ng the effectiveness in stabilizing Li metal batteries. | Chenxu Wang Xuewei Fu Shengnan Lin Jin Liu Wei-Hong Zhong | 2022 | Journal of Energy Chemistry2022，31，1： | 1 |
| 8 | Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles显示文摘Neutrophil extracellular traps(NETs)have been considered a significant unfavorable factor for wound healing in diabetes,but the mechanisms remain unclear.The therapeutic application of small extracellular vesicles(sEVs)derived from mesenchymal stem cells(MSCs)has received considerable attention for their properties.Hypoxic preconditioning is reported to enhance the therapeutic potential of MSC-derived sEVs in regenerative medicine.Therefore,the aim of this study is to illustrate the detailed mechanism of NETs in impairment of diabetic wound healing and develop a promising NET-targeting treatment based on hypoxic pretreated MSC-derived sEVs(Hypo-sEVs).Excessive NETs were found in diabetic wounds and in high glucose(HG)-induced neutrophils.Further research showed that high concentration of NETs impaired the function of fibroblasts through activating endoplasmic reticulum(ER)stress.Hypo-sEVs efficiently promoted diabetic wound healing and reduced the excessive NET formation by transferring miR-17-5p.Bioinformatic analysis and RNA interference experiment revealed that miR-17-5p in Hypo-sEVs obstructed the NET formation by targeting TLR4/ROS/MAPK pathway.Additionally,miR-17-5p overexpression decreased NET formation and overcame NET-induced impairment in fibroblasts,similar to the effects of Hypo-sEVs.Overall,we identify a previously unrecognized NET-related mechanism in diabetic wounds and provide a promising NET-targeting strategy for wound treatment. | Ziqiang Chu Qilin Huang Kui Ma Xi Liu Wenhua Zhang Shengnan Cui Qian Wei Huanhuan Gao Wenzhi Hu Zihao Wang Sheng Meng Lige Tian Haihong Li Xiaobing Fu Cuiping Zhang | 2023 | Bioactive Materials2023，，9： | 1 |
| 9 | Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting显示文摘Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in carcinogenesis.Therefore,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures.In this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise nanomedicine.Additionally,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine. | Xianglei Fu Yanbin Shi Tongtong Qi Shengnan Qiu Yi Huang Xiaogang Zhao Qifeng Sun Guimei Lin | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 10 | Tuning the crystalline and electronic structure of ZrO_(2)via oxygen vacancies and nano-structuring for polysulfides conversion in lithium-sulfur batteries显示文摘The recent emergence of tetragonal phases zirconium dioxide(ZrO_(2))with vacancies has generated significant interest as a highly efficient and stable electrocatalyst with potential applications in trapping polysulfides and facilitating rapid conversion in lithium-sulfur batteries(LSBs).However,the reduction of ZrO_(2)is challenging,even under strong reducing atmospheres at high temperatures and pressures.Consequently,the limited presence of oxygen vacancies results in insufficient active sites and reaction interfaces,thereby hindering practical implementation.Herein,we successfully introduced abundant oxygen vacancies into ZrO_(2)at the nanoscale with the help of carbon nanotubes(CNTs-OH)through hydrogen-etching at lower temperatures and pressures.The introduced oxygen vacancies on ZrO_(2-x)/CNTs-OH can effectively rearrange charge distribution,enhance sulfiphilicity and increase active sites,contributing to high ionic and electronic transfer kinetics,strong binding energy and low redox barriers between polysulfides and ZrO_(2-x).These findings have been experimentally validated and supported by theory calculations.As a result,LSBs assembled with the ZrO_(2-x)/CNTs-OH modified separators demonstrate excellent rate performance,superior cycling stability,and ultra-high sulfur utilization.Especially,at high sulfur loading of 6 mg cm^(-2),the area capacity is still up to 6.3 mA h cm^(-2).This work provides valuable insights into the structural and functional optimization of electrocatalysts for batteries. | Shengnan Fu Chaowei Hu Jing Li Hongtao Cui Yuanyuan Liu Kaihua Liu Yanzhao Yang Meiri Wang | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
| 11 | Transcriptome and morphological analyses of double flower formation in Dianthus chinensis显示文摘The double flower developmental process is regulated via a complex transcriptional regulatory network.To understand this highly dynamic and complex developmental process of Dianthus spp.,we performed a comparative analysis of floral morphology and transcriptome dynamics in simple flowers and double flowers.We found that the primordium of double flowers of‘X’was larger in size compared to that of simple flowers of‘L’in Dianthus chinensis.RNA-seq and Weighted Gene Co-expression Network Analysis(WGCNA)during flower development,identified stage-specific gene network modules.Expression analysis by RNA-seq indicated that a group of genes related to floral meristem identity,primordia position and polarity were highly expressed in double flowers genotypes compared to simple flowers genotypes,suggesting their roles in double-petal formation.A total of 21 DEGs related to petal number were identified between simple and double flowers.The experiments of in situ hybridization revealed that DcaAP2L,DcaLFY and DcaUFO genes were expressed in the intra-sepal boundary and petal boundary.We proposed a potential transcriptional regulatory network for simple and double flower development.This study provides novel insights into the molecular mechanism underlying double flower formation in Dianthus spp. | Xiaoni Zhang Shengnan Lin Quanshu Wu Qijian Wang Chunmei Shi Manzhu Bao Mohammed Bendahmane Xiaopeng Fu Zhiqiang Wu | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
| 12 | The mutation of ent-kaurene synthase,a key enzyme involved in gibberellin biosynthesis,confers a non-heading phenotype to Chinese cabbage(Brassica rapa L.ssp.pekinensis)显示文摘The presence of a leafy head is a vital agronomic trait that facilitates the evaluation of the yield and quality of Chinese cabbage.A non-heading mutant(nhm1)was identified in an ethyl methanesulfonate mutagenesis population of the heading Chinese cabbage double haploid line FT.Segregation analysis revealed that a single recessive gene,Brnhm1,controlled the mutant phenotype.Using MutMap,Kompetitive allele-specific PCR,and cloning analyses,we demonstrated that BraA07g042410.3C,which encodes an ent-kaurene synthase involved in the gibberellin biosynthesis pathway,is the nhm1 mutant candidate gene.A single-nucleotide mutation(C to T)in the fourth exon of BraA07g042410.3C caused an amino acid substitution from histidine to tyrosine.Compared to that of the wild-type FT,BraA07g042410.3C in the leaves of the nhm1 mutant had lower levels of expression.In addition,gibberellin contents were lower in the mutant than in the wild type,and the mutant plant phenotype could be restored to that of the wild type after exogenous GA3 treatment.These results indicate that BraA07g042410.3C caused the non-heading mutation.This is the first study to demonstrate a relationship between gibberellin content in the leaves and leafy head formation in Chinese cabbage.These findings facilitate the understanding of the mechanisms underlying leafy head development in Chinese cabbage. | Yue Gao Shengnan Huang Gaoyang Qu Wei Fu Meidi Zhang Zhiyong Liu Hui Feng | 2020 | Horticulture Research2020，7，1： | 0 |
| 13 | Ultrafast photocarrier and coherent phonon dynamics in type-II Dirac semimetal PtTe2 thin films probed by optical spectroscopy显示文摘We report the ultrafast photocarrier dynamics and coherent phonon excitation in type-II Dirac semimetal platinum ditelluride(PtTe2)thin films via femtosecond(fs)pump-probe spectroscopy at room temperature.Quantitative analysis revealed that the incoherent electronic relaxation consists of two components:a subpicosecond fast relaxation process and a slow component with a time constant of hundreds of picoseconds(ps).Furthermore,the launch of a coherent acoustic phonon(CAP)in the 20 nm film but absence in the 6.8 nm film uncovers the dominant role of temperature gradient in producing a strain wave.The sound velocity and Young’s modulus in the thick PtTe_(2) are determined to be 1.736 km/s and 29.5 GPa,respectively.In addition,the coherent optical phonon(COP)with a frequency of 4.7 THz corresponding to Te atoms out-of-plane A1g vibration has been well resolved in all films,which is ascribed to displacive excitation of coherent phonon(DECP).The observation of a strong probe-wavelength dependent COP amplitude reveals the resonant feature of the optical excitation-induced atomic displacement in PtTe2.Our findings provide deep insight into the excitation and dynamics of CAP and COP as well as the photocarriers’recovery pathway and lifetimes in PtTe_(2).Our study also demonstrates that the COP spectroscopy is a powerful tool to reveal the modulation of frequency-dependent optical constants induced by atomic vibrations,which may find applications in the fields of optoelectronics and ultrafast photonics. | Peng Suo Shengnan Yan Ruihua Pu Wenjie Zhang Di Li Jiaming Chen Jibo Fu Xian Lin Feng Miao Shi-Jun Liang Weimin Liu Guohong Ma | 2022 | Photonics Research2022，10，3： | 0 |
| 14 | BrDDB1A maintains regular growth of Chinese cabbage via UV tolerance显示文摘Normal plant growth and development ensures the timely maturity and expected yield of crops.The repair mechanism of genome damage under adverse circumstances is essential for maintaining regular plant growth.Herein,two allelic growth retardation mutants of Chinese cabbage,grm1 and grm2,were obtained from EMS-mutagenized populations of wild-type'FT'isolated-cultured microspores and seeds,respectively.Both mutants stably inherited and exhibited stunted growth with smaller leafy-heads.Genetic analysis and allelism test manifested that the mutated trait was triggered by a same single recessive nuclear gene.Via BSR-Seq,Brgrm1 was mapped to a target region including 20 genes on chromosome A09.Whole-genome re-sequencing revealed that BraA09g024830.3C in grm1 had a single base(A)deletion in the 17th exon,leading to a termination codon(TAG).Genotyping showed that the mutated phenotype co-segregated with the InDel in recombinants of the closest linkage markers.In addition,cloning of BraA09g024830.3C in grm2 found that a base substitution(G-A)occurred in the last base of the 1st intron causing an additional 263-bp retention in coding sequences,which in turn led to a termination codon(TAA).BraA09g024830.3C(BrDDB1A)is a homolog of Arabidopsis thaliana Damaged DNA Binding Protein 1A(DDB1A),a key gene of UV tolerance involved in DNA damage repair.The two mutants exhibited normal plant growth identical with wild-type under an extremely low UV radiation.Our results demonstrated that BrDDB1A contributes to maintaining regular plant growth in Chinese cabbage,which provide insights into elucidating the molecular mechanism underlying Chinese cabbage growth and development. | Meidi Zhang Jiaqi Zou Shengnan Huang Wei Fu Yue Gao Gaoyang Qu Yonghui Zhao Ying Zhao Zhiyong Liu Hui Feng | 2022 | Vegetable Research2022，2，1： | 0 |
| 15 | Fine mapping of Brebm6,a gene conferring the early-bolting phenotype in Chinese cabbage(Brassica rapa ssp.pekinensis)显示文摘In flowering plants,bolting signals the transition from vegetative to reproductive growth,and it is consequently an important agronomic trait for the stalk-use Chinese cabbage Baicaitai.There is an urgent need to create germplasm resources for Chinese cabbage that have easy bolting characteristics.In this investigation,early bolting mutant 6(ebm6)was created by treating Chinese cabbage double haploid(DH)'FT'seeds with an ethyl methanesulfonate(EMS)solution.Phenotypic analysis showed that the mutant ebm6 flowered remarkably earlier than the wild-type'FT'.Genetic analysis indicated that this early bolting trait was controlled by a recessive nuclear gene.In mutant ebm6,the causal gene BraA02g003340.3C(BrFLC2)was predicted using MutMap and Kompetitive Allele Specific PCR genotyping(KASP),as the gene encodes a MADSbox transcription factor.The 3259-bp BrFLC2 gene possessed seven exons and six introns,and in the first exon,a single nucleotide C-to-T substitution in the highly conserved MADS-box domain resulted in the premature termination of translation of the BrFLC2 protein sequence.This research supported a critical role of BrFLC2 in controlling flowering time in B.rapa.The early flowering ebm6 mutant could also be a useful material in Baicaitai breeding. | Wei Fu Shengnan Huang Zhiyong Liu Yue Gao Meidi Zhang Nan Wang Gaoyang Qu Hui Feng | 2021 | Vegetable Research2021，1，1： | 0 |
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