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| 1 | Overall assessment of antibiotic substitutes for pigs:a set of meta-analyses显示文摘Background:Antibiotic growth promoters are widely used to improve weight gain.However,the abuse of antibiotics can have many negative effects on people.Developing alternatives to antibiotics is an urgent need in livestock production.We aimed to perform a meta-analysis and network meta-analysis(NMA)to investigate the effects of feed additives as potential antibiotic substitutes(ASs)on bacteriostasis,growth performance,intestinal morphology and immunity.Furthermore,the primary,secondary,and tertiary ASs were defined by comparing their results with the results of antibiotics.Results:Among 16,309 identified studies,37 were summarized to study the bacteriostasis effects of feed additives,and 89 were included in the meta-analysis and NMA(10,228 pigs).We summarized 268 associations of 57 interventions with 32 bacteria.The order of bacteriostasis effects was as follows:antimicrobial peptides(AMPs)≈antibiotics>organic acids>plant extracts>oligosaccharides.We detected associations of 11 feed additives and 11 outcomes.Compared with a basal diet,plant extract,AMPs,probiotics,microelements,organic acids,bacteriophages,lysozyme,zymin,and oligosaccharides significantly improved growth performance(P<0.05);organic acids,probiotics,microelements,lysozyme,and AMPs remarkably increased the villus height:crypt depth ratio(V/C)(P<0.05);and plant extracts,zymin,microelements,probiotics,and organic acids notably improved immunity(P<0.05).The optimal AMP,bacteriophage,lysozyme,microelements,oligosaccharides,organic acids,plants,plant extracts,probiotics,and zymin doses were 0.100%,0.150%,0.012%,0.010%,0.050%,0.750%,0.20%,0.040%,0.180%,and 0.100%,respectively.Compared with antibiotics,all investigated feed additives exhibited no significant difference in effects on growth performance,IgG,and diarrhoea index/rate(P>0.05);AMPs and microelements significantly increased V/C(P<0.05);and zymin significantly improved lymphocyte levels(P<0.05).Furthermore,linear weighting sum models were used to comprehensively estimate the overall impact of each feed additive on pig growth and health.Conclusions:Our findings suggest that AMPs and plant extracts can be used as primary ASs for weaned piglets and growing pigs,respectively.Bacteriophages,zymin,plants,probiotics,oligosaccharides,lysozyme,and microelements can be regarded as secondary ASs.Nucleotides and organic acids can be considered as tertiary ASs.Future studies should further assess the alternative effects of combinational feed additives. | Bocheng Xu Jie Fu Luoyi Zhu Zhi Li Mingliang Jin Yizhen Wang | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 9 |
| 2 | Dietary fatty acids in gut health: Absorption, metabolism and function显示文摘In biological responses,fatty acids(FA)are absorbed and metabolized in the form of substrates for energy production.The molecular structures(number of double bonds and chain length)and composition of dietary FA impact digestion,absorption and metabolism,and the biological roles of FA.Recently,increasing evidence indicates that FA are essentially utilized as an energy source and are signaling molecules that exert physiological activity of gut microbiota and immune responses.In addition,FA could serve as natural ligands for orphan G protein-coupled receptors(GPCR),also called free fatty acid receptors(FFAR),which intertwine metabolic and immune systems via multiple mechanisms.The present review explores the recent findings on FA absorption and its impact on gut health,particularly addressing the mechanism by which dietary FA potentially influences intestinal microbiota and epithelial functions.Also,this work attempts to uncover research ideas for devising future strategies for manipulating the composition of dietary FA to regulate gut health and support a normal immune system for metabolic and immune disorders. | E.Xu Chao Chen Jie Fu Luoyi Zhu Junlan Shu Mingliang Jin Yizhen Wang Xin Zong | 2021 | Animal Nutrition2021，，4： | 4 |
| 3 | YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock显示文摘Dear editor,Endotoxic shock usually results from infection-induced physiologic, pathologic, and biologic abnormalities(Singer et al., 2016). Undeniably, it is still a profoundly damaging and life-threatening condition for many individuals(Guan et al., 2019;Ding et al., 2021). Studies have shown that it is associated with the accumulation of apoptotic markers(Kayagaki et al., 2015;Zong et al., 2019). | Xin Zong Xiao Xiao Fu Jie Yuanzhi Cheng Mingliang Jin Yulong Yin Yizhen Wang | 2021 | Science China(Life Sciences)2021，64，11： | 3 |
| 4 | Analyzing Electricity Consumption via Data Mining显示文摘This paper proposes a model to analyze the massive data of electricity.Feature subset is determined by the correla-tion-based feature selection and the data-driven methods.The attribute season can be classified successfully through five classi-fiers using the selected feature subset,and the best model can be determined further.The effects on analyzing electricity consump-tion of the other three attributes,including months,businesses,and meters,can be estimated using the chosen model.The data used for the project is provided by Beijing Power Supply Bureau.We use WEKA as the machine learning tool.The models we built are promising for electricity scheduling and power theft detection. | LIU Jinshuo LAN Huiying FU Yizhen WU Hui LI Peng | 2012 | Wuhan University Journal of Natural Sciences2012，17，2： | 1 |
| 5 | Mechanisms and regulation of defensins in host defense显示文摘As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host defense.Their biological functions in innate immunity,as well as their structure and activity relationships,along with their mechanisms of action and therapeutic potential,have been of great interest in recent years.To highlight the key research into the role of defensins in human and animal health,we first describe their research history,structural features,evolution,and antimicrobial mechanisms.Next,we cover the role of defensins in immune homeostasis,chemotaxis,mucosal barrier function,gut microbiota regulation,intestinal development and regulation of cell death.Further,we discuss their clinical relevance and therapeutic potential in various diseases,including infectious disease,inflammatory bowel disease,diabetes and obesity,chronic inflammatory lung disease,periodontitis and cancer.Finally,we summarize the current knowledge regarding the nutrient-dependent regulation of defensins,including fatty acids,amino acids,microelements,plant extracts,and probiotics,while considering the clinical application of such regulation.Together,the review summarizes the various biological functions,mechanism of actions and potential clinical significance of defensins,along with the challenges in developing defensins-based therapy,thus providing crucial insights into their biology and potential clinical utility. | Jie Fu Xin Zong Mingliang Jin Junxia Min Fudi Wang Yizhen Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 6 | Rice3K56 is a high-quality SNP array for genome-based genetic studies and breeding in rice(Oryza sativa L.)显示文摘Single nucleotide polymorphism(SNP)genotyping arrays provide an optimal high-throughput platform for genetic research and molecular breeding programs in both animals and plants.In this study,a highquality and custom-designed Rice3K56 SNP array was developed with the resequencing data of 3024 rice accessions worldwide,which was then tested extensively in 192 representative rice samples.Printed on the Gene Titan chips of Affymetrix Axiom each containing 56,606 SNP markers,the Rice3K56 array has a high genotyping reliability(99.6%),high and uniform genome coverage(an average of 6.7-kb between adjacent SNPs),abundant polymorphic information and easy automation,compared with previously developed rice SNP arrays.When applied in rice varietal differentiation,population diversity analysis,gene mapping of 13 complex traits by a genome-wide association study analysis(GWAS),and genome selection experiments in a recombinant inbred line and a multi-parent advanced generation inter-cross populations,these properties of the Rice3K56 array were well demonstrated for its power and great potential to be a highly efficient tool for rice genetic research and genomic breeding. | Chaopu Zhang Min Li Lunping Liang Jun Xiang Fan Zhang Chenyang Zhang Yizhen Li Jing Liang Tianqing Zheng Fanlin Zhang Hua Li Binying Fu Yingyao Shi Jianlong Xu Bingchuan Tian Zhikang Li Wensheng Wang | 2023 | The Crop Journal2023，11，3： | 0 |
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