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| 1 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 2 | Metabolomic Screening Applied to Rice FOX Arabidopsis Lines Leads to the Identification of a Gene-Changing Nitrogen Metabolism显示文摘植物 metabolomics 作为一个强大的工具发展了检验基因功能并且获得更深的卓见进植物房间的生理学。在这研究,我们屏蔽了 Arabidopsis 线 overexpressing 米饭全身(FL ) 用煤气的 chromatographytime-of-flight 团 spectrometry (GCTOF/MS ) 的 cDNAs (米饭狐狸 Arabidopsis 线) 基于技术识别引起了新陈代谢的变化的米饭基因。这个屏蔽系统允许显示出改变的代谢物侧面的候选人线的快、可靠的鉴定。我们执行了怀有 Arabidopsis 的侧面的机关边界(高球) 领域(LBD )/Asymmetric 象 Leaves2 一样(ASL ) 基因的米饭 ortholog 的 FL cDNA 的一根米饭狐狸 Arabidopsis 线的 metabolomic 和 transcriptomic 分析, At-LBD37/ASL39。调查米饭狐狸 Arabidopsis 线在与氮新陈代谢有关的代谢物的层次显示出突出的变化。象从 Arabidopsis At-LBD37/ASL39-overexpressor 植物的代谢物分析的结果一样的 transcriptomic 数据与这些调查结果一致。而且, Os-LBD37/ASL39-overexpressing 米饭植物的 metabolomic 和 transcriptomic 分析显示 Os-LBD37/ASL39 在米饭与与氮新陈代谢有关的过程被联系。因此,一个基于 metabolomics 的屏蔽方法的联合和一条 gain-of-function 途径为在 Arabidopsis 和米饭的新奇基因的快速的描述是有用的。 | Doris Albinsky Miyako Kusano Mieko Higuchi Naomi Hayashi Makoto Kobayashi Atsushi Fukushima Masaki Mori Takanari Ichikawa Keiko Matsui Hirofumi Kuroda Yoko Horii Yuko Tsumoto Hitoshi Sakakibara Hirohiko Hirochika Minami Matsui Kazuki Saito | 2010 | Molecular Plant2010，3，1： | 15 |
| 3 | 重新研究TP53基因突变和免疫组化的关系——157例弥漫型胶质瘤的对照分析显示文摘p53免疫组化与TP53突变状态之间的关系一直存在争议。本组研究重新评估p53免疫组化提示TP53突变状态的价值。通过外显子测序,共检测了157例弥漫型胶质瘤( WHO Ⅱ~Ⅳ级)冷冻组织的TP53基因第4~10外显子。对应所有病例的福尔马林固定石蜡包埋组织检测p53免疫组化(克隆号DO-7),评估表达强度和比率。66例突变病例中发现72个突变,包括60个错义突变,5个无义突变,4个缺失和3个剪切位点变异。通过 ROC曲线分析发现大于10%的肿瘤细胞强阳性可最大程度地提示突变。 | Takami H Yoshida A Fukushima S 刘雪咏 王行富 | 2015 | 临床与实验病理学杂志2015，31，7： | 14 |
| 4 | Relationships among alcoholic liver disease,antioxidants,and antioxidant enzymes显示文摘Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide.The metabolism of ethanol generates reactive oxygen species,which play a significant role in the deterio-ration of alcoholic liver disease(ALD).Antioxidant phytochemicals,such as polyphenols,regulate the expression of ALD-associated proteins and peptides,namely,catalase,superoxide dismutase,glutathione,glutathione peroxidase,and glutathione reductase.These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelch-like ECH-associated protein 1--NF--E2--related factor--2 pathway and antioxidant responsive elements.Furthermore,these antioxidants are reported to alleviate cell injury caused by oxidants or inflammatory cytokines.These phenomena are likely induced via the regulation of mitogen--activating protein kinase(MAPK)pathways by plant antioxidants,similar to preconditioning in ischemia-reperfusion models.Although the relationship between plant antioxidants and ALD has not been adequately investigated,plant antioxidants may be preventive for ALD because of their electrophilic and regulatory activities in the MAPK pathway. | Kyu-Ho Han Naoto Hashimoto Michihiro Fukushima | 2016 | World Journal of Gastroenterology2016，22，1： | 14 |
| 5 | Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients显示文摘AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy(LAC) in elderly colorectal cancer patients with open colectomy(OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC(mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss(mean difference =-93.3738, 95%CI:-132.3437 to-54.4039, P < 0.0001), overall morbidity(OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection(OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus(OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications(OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes(median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival(mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival(mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes(mean difference =-0.1360, 95%CI:-4.0553-3.7833, P = 0.9458).CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer. | Shoichi Fujii Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Koichi Okamoto Takeshi Tsuchiya Keijiro Nozawa Keiji Matsuda Yojiro Hashiguchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 10 |
| 6 | Clinical significance of serum levels of vascular endothelial growth factor and its receptor in biliary disease and carcinoma显示文摘AIM: To investigate the clinical significance of serum vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (VEGFR1/Flt-1) (sVEGFR1) levels in biliary diseases.METHODS: We analyzed the serum levels of these proteins in patients with acute cholangitis (group 1), biliary malignancies (group 2), and primary biliary cirrhosis or primary sclerosing cholangitis (group 3), and in healthy donors (group 4). The influence of inflammation was also analyzed. Serum VEGF levels were expressed as VEGF per platelet (VEGF/PLT, pg/106) in order to exclude the influence of platelet counts.RESULTS: sVEGFR1 levels were significantly higher in groups 1 and 2 than in the control group, but did not correlate with inflammatory markers. VEGF/PLT levels were generally higher in patients with active inflammation than in those with carcinoma. C-reactive protein strongly correlated with the levels of serum VEGF independently of platelet and leukocyte counts, even in cancer patients. In cancer patients, VEGF/PLT and sVEGFR1 levels might be indicators for evaluating the effect of medical treatment or the disease progression.CONCLUSION: Serum VEGF and VEGFR1 might be useful markers for gauging the clinical effect of various treatments on patients. | Munechika Enjoji Makoto Nakamuta Koji Yamaguchi Satoshi Ohta Kazuhiro Kotoh Marie Fukushima Masami Kuniyoshi Tomomi Yamada Masao Tanaka Hajime Nawata | 2005 | World Journal of Gastroenterology2005，11，8： | 9 |
| 7 | Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs显示文摘AIM: To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs.METHODS: The right lateral lobe of pigs, i.e. the 25%of the liver, was transplanted orthotopically. The pigs were divided into two groups: graft without portocaval shunt (n = 11) and graft with portocaval shunt (n=11).Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated.RESULTS: In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h after transplantation. In the group with portocaval shunt,eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 mL/min/100 g liver tissue,respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 mL/min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively (P<0.01). As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed after reperfusion, but these findings were not recognized in the group with portocaval shunt.CONCLUSION: These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury. | Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita Hideyuki Yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi | 2005 | World Journal of Gastroenterology2005，11，44： | 8 |
| 8 | Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats显示文摘AIM: To investigate the total cytochrome P450 (CYP) content, microsomal mixed-function oxidase (MFO) activity, and expression of mRNAs for various CYP isozymes in a simple rat model of reversible obstructive jaundice. METHODS: Obstructive jaundice was created in male rats by causing bile duct obstruction with polyester tape. In another group of rats, bile duct obstruction was followed by internal biliary drainage after releasing the tape. The expression of various CYP isozyme mRNAs was semi-quantitatively assessed by competitive RT- PCR. RESULTS: The total CYP content and microsomal MFO activity showed a significant decrease after biliary obstruction, but returned to respective control levels after biliary drainage. A marked reduction in the expression of CYP1A2, 2B1/2, 2C11, 2E1, 3A1, and 3A2 mRNA was detected during biliary obstruction, while expression increased significantly toward the control level after biliary drainage. Although expression of CYP4A1 mRNA showed no reduction during biliary obstruction, it still increased significantly after biliary drainage. CONCLUSION: These results suggest that not only obstructive jaundice, but also the subsequent internal biliary drainage may affect regulatory medications of the synthesis of individual CYP isozymes differently. | Shintaro Fukushima Hiroyasu Okuno Nobuyuki Shibatani Yoshitsugu Nakahashi Toshihito Seki Kazuichi Okazaki | 2008 | World Journal of Gastroenterology2008，14，16： | 7 |
| 9 | Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan显示文摘AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral load.METHODS:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were enrolled.Sustained virological response(SVR) and clinical parameters were evaluated.RESULTS:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved SVR.Early virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,respectively.The clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P < 0.0001),adherence to peg-IFN(≥ 80% of planned dose) at week 12(48.1% vs 13.6%,P = 0.00036),adherence to peg-IFN at week 48(54.7% vs 16.2%,P < 0.0001) and adherence to RBV at week 48(56.1% vs 32.1%,P = 0.0102) were determined using univariate analysis,and EVR and adherence to peg-IFN at week 48 were determined using multivariate analysis.In the older patient group(> 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with SVR.CONCLUSION:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru Kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki Motoyasu Ishii Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，47： | 7 |
| 10 | 原发性颅内生殖细胞肿瘤全基因组甲基化分析提示生殖细胞瘤为原始生殖细胞起源显示文摘颅内生殖细胞肿瘤(iGCTs)是日本14岁以下儿童的第二常见脑肿瘤。WHO分类承认了iGCTs的数个亚型,传统将这些亚型分为纯生殖细胞瘤和非生殖细胞瘤性生殖细胞肿瘤。最近详尽的基因组研究显示MAPK和(或)P13K通路的基因突变在iGCTs中很常见,然而,不同亚型的发生,为何经常表现为混合性生殖细胞肿瘤, | Fukushima S Yamashita S Kobayashi H 蔡珊珊 王行富 | 2017 | 临床与实验病理学杂志2017，33，6： | 7 |
| 11 | Nature:单核细胞SatM导致组织纤维化显示文摘在一项新的研究中,来自日本大阪大学免疫学前沿研究中心(IFReC)的研究人员报道了一类新的他们称之为SatM的单核细胞。针对小鼠的研究表明SatNI可能是导致组织纤维化的原因,而且成为一种治疗很少有有效疗法的疾病的新药物靶标。 | Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Takashi Satoh, Katsuhiro Nakagawa, Fumihiro Yamane, Kiyoharu Fukushima, Isao Ebina Shizuo Akira Fuminori Sugihara Yoshichika Yoshioka Ryusuke Kuwahara Motooki Ashihara, Yosuke Minowa Isao Ebina Atsushi Kumanogoh Atsushi Kumanogoh | 2017 | 现代生物医学进展2017，17，3： | 7 |
| 12 | IMP3、GLUT、EMA、CD146和desmin对鉴别恶性间皮瘤与活跃间皮细胞的免疫表型比较分析显示文摘作者对34例恶性间皮瘤和40例生长活跃的间皮细胞用免疫组化方法进行鉴别并进行统计比较分析。恶性间皮瘤阳性标记有胰岛素样生长因子2、信使RNA结合蛋白3(IMP3)、葡萄糖载体1(GLUTl)、上皮膜抗原(EMA)、CDl46,4种抗体的敏感性分别是94%、85%、79%、和71%,特异性分别是78%、100%、88%和98%。在恶性间皮瘤中,EMA的表达明显低于IMP3、GLUT和CDl46(P〈0.001)。ROC曲线(受试者工作特性曲线)面积,IMP3最高,为0.95,GLUT1其次,为0.93。结合最佳拐点,IMP3(30%)和GLUT(10%)的敏感性是100%,特异性是95%。因此,对于鉴别诊断恶性间皮瘤和生长活跃的间皮组织,联合使用IMP3和GLUTl最合适。 | Minato H Kurose N Fukushima M 徐磊 孙咏梅 | 2014 | 临床与实验病理学杂志2014，30，2： | 6 |
| 13 | Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins显示文摘瞄准:Lafutidine,一个组织安 H2 受体对手,展览胃保护的行动由 capsaicin 敏感的传入神经元(CSN ) 调停了。我们比较了在 lafutidine 和辣椒辣素之间的效果,关于和内长的前列腺素(PG ) 的相互作用,氮的氧化物(没有) 并且传入神经元,包括短暂受体潜力 vanilloid 子类型 1 (TRPV1 ) 。方法:男 SD 老鼠和 C57BL/6 老鼠,野类型并且 prostacyclin IP 受体大美人动物,在禁食的 18 h 以后被使用。胃的损害被 HCl/ethanol 的 po 管理导致(60% 在 150 mmol/L HCl ) 在为老鼠的 1 mL 或为老鼠的 0.3 mL 的体积。结果:lafutidine 和辣椒辣素(1-10 mg/kg, po ) 对在老鼠和老鼠的 HCl/ethanol 的负担得起的剂量依赖者保护。效果被两个稀释有 N (G)-nitro-L-arginine 甲基酉旨的 CSN 和预告的处理的脱离,然而,仅仅辣椒辣素的效果被 capsazepine, TRPV1 对手,以及消炎痛的优先的管理减轻。Lafutidine 在 IP 受体大美人老鼠保护了胃免于 HCl/ethanol,类似于野类型的动物,当辣椒辣素没能在缺乏 IP 受体的动物负担得起保护时。任何一个这些代理人都没在老鼠胃影响粘膜 PGE2 或 6-keto PGF (1alpha ) 内容。辣椒辣素唤起了增加在[Ca2+] 在老鼠 TRPV1-transfected HEK293 房间的 i 当时 lafutidine 不。结论:这些结果建议尽管 lafutidine 和辣椒辣素展出,胃保护的行动由 CSN 调停了,他们的效果的模式在内长的 PGs/IP 受体和 TRPV1 上关于相关性不同。lafutidine 在除 TRPV1 以外的还未辩别出的地点与 CSN 交往,这被假定。 | Kazuhiro Fukushima Yoko Aoi Shinichi Kato Koji Takeuchi | 2006 | World Journal of Gastroenterology2006，12，19： | 6 |
| 14 | Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice显示文摘瞄准:在 Kupffer 房间的功能上检验 adiponectin 的效果,脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法:D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间,从 Sprague-Dawley 孤立老鼠,是 preincubated 与或没有 adiponectin,然后与 LPS 对待。结果:在猛烈老鼠, GalN/LPS 注射显著地降低了幸存率,显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间, LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次,与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论:Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产,并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。 | Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 15 | Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment显示文摘A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin,and her HCV-RNA became negative at wk 12,but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Jun Inoue Eiji Kakazu Yasunori Matsuda Osamu Kido Yu Nakagome Osamu Kimura Noriyuki Obara Yuta Wakui Takao Iwasaki Tooru Shimosegawa | 2007 | World Journal of Gastroenterology2007，13，32： | 5 |
| 16 | High false-negative proportion of intraoperative histological examination as a serious problem for clinical application of sentinel node biopsy for early gastric cancer: final results of the Japan Clinical Oncology Group multicenter trial JCOG0302显示文摘 | Isao Miyashiro Masahiro Hiratsuka Mitsuru Sasako Takeshi Sano Junki Mizusawa Kenichi Nakamura Atsushi Nashimoto Akira Tsuburaya Norimasa Fukushima | 2014 | Gastric Cancer2014，，2： | 5 |
| 17 | Effect of equal-channel angular pressing on pitting corrosion resistance of anodized aluminum-copper alloy显示文摘The effect of equal-channel angular pressing(ECAP) on the pitting corrosion resistance of anodized Al-Cu alloy was investigated by electrochemical techniques in a solution containing 0.2 mol/L AlCl3 and also by surface analysis.Anodizing was conducted for 20 min at 200 and 400 A/m2 in a solution containing 1.53 mol/L H2SO4 and 0.018 5 mol/L Al2(SO4)3·16H2O at 20 ℃.Anodized Al-Cu alloy was immediately dipped in boiling water for 20 min to seal the micro pores present in anodic oxide films.The time required before initiating pitting corrosion of anodized Al-Cu alloy is longer with ECAP than without,indicating that ECAP process improves the pitting corrosion resistance of anodized Al-Cu alloy.Second phase precipitates such as Si,Al-Cu-Mg and Al-Cu-Si-Fe-Mn intermetallic compounds are present in Al-Cu alloy and the size of these precipitates is greatly decreased by application of ECAP.Al-Cu-Mg intermetallic compounds are dissolved during anodization,whereas the precipitates composed of Si and Al-Cu-Si-Fe-Mn remain in anodic oxide films due to their more noble corrosion potential than Al.FE-SEM and EPMA observation reveal that the pitting corrosion of anodized Al-Cu alloy occurs preferentially around Al-Cu-Si-Fe-Mn intermetallic compounds,since the anodic oxide films are absent at the boundary between the normal oxide films and these impurity precipitates.The improvement of pitting corrosion resistance of anodized Al-Cu alloy processed by ECAP appears to be attributed to a decrease in the size of precipitates,which act as origins of pitting corrosion. | In-Joon SON Hiroaki NAKANO Satoshi OUE Shigeo KOBAYASHI Hisaaki FUKUSHIMA Zenji HORITA | 2009 | 中国有色金属学会会刊:英文版2009，19，4： | 5 |
| 18 | Efects of amine, amine salt and amide on the behaviour of carbon dioxide absorption into calcium hydroxide suspension to precipitate calcium carbonate显示文摘The amount of carbon dioxide(CO2) absorption and calcium ion(Ca2+) concentration besides the pH of aqueous solution were observed during the CO2 absorption to precipitate calcium carbonate(CaCO3) from calcium hydroxide(Ca(OH)2). A reaction rate-limiting efect of an amount of CO2 absorption without any organic additives in the early stage of the precipitation was observed, which was attributed to an interruption efect of bicarbonate ion(HCO 3) on the precipitation of CaCO3. The improvement for the reaction rate was achieved not only by amine additives but also by neutral additives such as ε-caprolactam or amine salt. When the hexamethylene diamine was dissolved in the solution, successive change of crystal forms of CaCO3 aragonite to calcite in aqueous suspensions, confirmed by Ca2+ concentration change and X-ray difraction, was concluded that a local environment around the amine group in aqueous solution and an interaction of the diamine with precipitated CaCO3 particles were important factors for these reactions. | Wittaya Chuajiw Mitsuru Nakano Kazumasa Takatori Toshiya Kojima Yoshiki Wakimoto Yoshiaki Fukushima | 2013 | Journal of Environmental Sciences2013，25，12： | 5 |
| 19 | High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosis显示文摘AIM: In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life. Since musculature is catabolized to supply amino acids for albumin synthesis in malnutritional cirrhotic patients, muscular volume is hypothesized to play an important role in albumin production. Therefore, we investigated the correlation between serum albumin levels and the fat-free mass (FFM) in cirrhotic patients.METHODS: Fifty-seven patients (26 males and 31 females)with compensated liver cirrhosis were evaluated. Patients with edema or ascites were excluded from the study.Healthy volunteers (n = 104; 48 males and 56 females)were also evaluated as controls. FFM was measured using 5-500 kHz multifrequency bioelectric impedance analysis.To minimize the difference in FFM distribution between males and females, we introduced a new marker, relative FFM (rFFM), which represents the ratio of FFM in a patient relative to that in a volunteer of the same height. Following FFM measurement, the serum albumin levels of patients were assayed monthly.RESULTS: In patients with active cirrhosis (alanine aminotransaminase [ALT] >50 U/L), both albumin (the difference between maximum and minimum levels) and the standard deviation of albumin levels (SD-albumin) during the observation period showed a significant correlation with rFFM. Multiple linear regression analysis using variables such as rFFM, platelet number, and serum cholesterol levels,choline esterase, albumin, bilirubin, and ALT revealed that rFFM and ALT were significant and independent factors that influenced albumin or SD-albumin in cirrhotic patients.CONCLUSION: Our results indicate that cirrhotic patients with high rFFM showed less of a decrease in albumin levels, and that the muscle volume is one of the most important factors for maintaining serum albumins level in active cirrhosis. Exercise and protein-rich nutrition at the early stage of liver cirrhosis may be advisable for maintaining or increasing muscular volume. | Kazuhiro Kotoh Makoto Nakamuta Marie Fukushima Chitose Matsuzaki Munechika Enjoji Hironori Sakai Hajime Nawata | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 20 | Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis显示文摘Eosinophilic cholangiopathy is a rare condition characterized by eosinophilic infiltration of the biliary tract and causes sclerosing cholangitis.We report a patient with secondary sclerosing cholangitis with eosinophilic cholecystitis.A 46-year-old Japanese man was admitted to our hospital with jaundice. Computed tomography revealed dilatation of both the intrahepatic and extrahepatic bile ducts,diffuse thickening of the wall of the extrahepatic bile duct,and thickening of the gallbladder wall.Under the diagnosis of lower bile duct carcinoma,he underwent pyloruspreserving pancreatoduodenectomy and liver biopsy. On histopathological examination,conspicuous fibrosis was seen in the lower bile duct wall.In the gallbladder wall,marked eosinophilic infiltration was seen.Liver biopsy revealed mild portal fibrosis.He was diagnosed as definite eosinophilic cholecystitis with sclerosing cholangitis with unknown etiology.The possible etiology of sclerosing cholangitis was consequent fibrosis from previous eosinophilic infiltration in the bile duct.The clinicopathological findings of our case and a literature review indicated that eosinophilic cholangiopathy could cause a condition mimicking primary sclerosing cholangitis(PSC).Bile duct wall thickening in patientswith eosinophilic cholangitis might be due to fibrosis of the bile duct wall.Eosinophilic cholangiopathy might be confused as PSC with eosinophilia. | Fumihiko Miura Takehide Asano Hodaka Amano Masahiro Yoshida Naoyuki Toyota Keita Wada Kenichiro Kato Tadahiro Takada Junichi Fukushima Fukuo Kondo Hajime Takikawa | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
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