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| 1 | Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer显示文摘Postoperative recurrence occurs in approximately half of patients with non-small cell lung cancer(NSCLC), even after complete resection. Disease recurrence after surgical resection reduces the patient's life expectancy sharply. The prognosis after postoperative recurrence is considered to largely depend on both the mode of first recurrence(distant, locoregional or combined) and the treatment modality:(1) The majority of cases of postoperative recurrence involve distant metastasis with or without locoregional recurrence. Platinum-based systemic chemotherapy is practically accepted as the treatment for these diseases on the basis of evidence for original stage Ⅳ disease. The advent of both pemetrexed and molecular-targeted drugs has improved the survival of nonsquamous NSCLC and changed the chemotherapeutic algorithm for NSCLC;(2) Among patients with distant metastatic recurrence without locoregional recurrence at the primary tumor site, the metastasis is often limited in both organ and number. Such metastases are referred to as oligometastases. Local therapy, such as surgical resection and radiotherapy, has been suggested to be the first-line treatment of choice foroligometastatic recurrence; and(3) While locoregional recurrence is likely to cause troublesome symptoms, it is a potentially limited disease. Therefore, providing local control is important, and radiation is usually beneficial for treating local recurrence. In order to obtain better control of the disease and provide treatment with curative intent in patients with limited disease, the administration of concurrent platinum-based chemoradiotherapy is recommended according to the results of originally nonresectable stage ⅢA and ⅢB disease. | Tokujiro Yano Tatsuro Okamoto Seiichi Fukuyama Yoshihiko Maehara | 2014 | World Journal of Clinical Oncology2014，5，5： | 10 |
| 2 | Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs:A case report显示文摘BACKGROUND Despite an expanding number of studies on intraductal papillary neoplasm of the bile duct(IPNB),distant metastasis remains unexplained especially in cases of carcinoma in situ.In the present study,we report a rare and interesting case of IPNB without invasive components that later metastasized to lungs and brain.CASE SUMMARY A 69-year-old male was referred to our hospital due to suspected cholangiocarcinoma.Laboratory tests on admission reported a mild elevation of alkaline phosphatase,γ-glutamyl transpeptidase,and total bilirubin in serum.Endoscopic retrograde cholangiography revealed a filling defect in the common bile duct(CBD)extending to the left hepatic duct.Peroral cholangioscopy delineated a tumor in the CBD that had a papillary pattern.Multidetector computed tomography and magnetic resonance cholangiopancreatography detected partial blockage ot interlude in the CBD leading to cholestasis without evidence of metastasis.Therefore,a diagnosis of IPNB cT1N0M0 was established.Left hepatectomy with bile duct reconstruction was performed.Pathological examination confirmed an intraepithelial neoplasia pattern without an invasive component and an R0 resection achievement.The patient was monitored carefully by regular examinations.However,at 32 mo after the operation,a 26 mm tumor in the lungs and a 12 mm lesion in the brain were detected following a suspicious elevated CA 19-9 level.Video-assisted thoracoscopic surgery of left upper lobectomy and stereotactic radiotherapy are indicated.In addition to histopathological results,a genomic profiling analysis using whole exome sequencing subsequently confirmed lung metastasis originating from bile duct cancer.CONCLUSION This case highlights the important role of genomic profiling analysis using whole exome sequencing in identifying the origin of metastasis in patients with IPNB. | Nguyen Hai Nam Kojiro Taura Masashi Kanai Keita Fukuyama Norimitsu Uza Hirona Maeda Yojiro Yutaka Toyofumi F Chen-Yoshikawa Manabu Muto Shinji Uemoto | 2020 | World Journal of Gastroenterology2020，26，3： | 5 |
| 3 | A directional slacks-based measure of technical inefficiency显示文摘 | Hirofumi Fukuyama William L. Weber | 2008 | Socio-Economic Planning Sciences2008，，4： | 4 |
| 4 | Cancer/testis antigen, Kita-Kyushu lung cancer antigen-1 and ABCD stratification for diagnosing gastric cancers显示文摘BACKGROUND The ABCD stratification[combination of serum pepsinogen(PG)levels and titers of antibody(immunoglobulin G,IgG)against Helicobacter pylori(H.pylori)]is effective for the classification of individuals at risk of developing gastric cancer(GC).The Kita–Kyushu lung cancer antigen-1(KK-LC-1)is a Cancer/Testis antigen frequently expressed in GC.AIM To evaluate the effectiveness of KK-LC-1 and ABCD stratification in the diagnosis of GC.METHODS We analyzed the gene expression of KK-LC-1 in surgical specimens obtained from GC tumors.The levels of serum PG I/PG II and IgG against H.pylori were measured.According to their serological status,the patients were classified into the four groups of the ABCD stratification.RESULTS Of the 77 examined patients,63(81.8%)expressed KK-LC-1.The IgG titers of H.pylori and PG II were significantly higher in patients expressing KK-LC-1 than those measured in patients not expressing KK-LC-1(P=0.0289 and P=0.0041,respectively).The expression of KK-LC-1 in group C[PG method(+)/H.pylori infection(+)]was as high as 93.9%high.KK-LC-1 was also detected in group A[-/-].CONCLUSION The KK-LC-1 expression in GC was associated with H.pylori infection and atrophic status,so that,KK-LC-1 may be a useful marker for the diagnosis of GC. | Akiko Shida Takashi Fukuyama Nobue Futawatari Haruki Ohmiya Yoshinobu Ichiki Tetsuro Yamashita Yatsushi Nishi Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe Yoshihito Takahashi | 2020 | World Journal of Gastroenterology2020，26，4： | 3 |
| 5 | Early gastric cancer frequently has high expression of KKLC-1, a cancer-testis antigen显示文摘AIM To assess cancer-testis antigens(CTAs) expression in gastric cancer patients and examined their associations with clinicopathological factors.METHODS Eighty-three gastric cancer patients were evaluated in this study. Gastric cancer specimens were evaluated for the gene expression of CTAs, Kitakyushu lung cancer antigen-1(KK-LC-1), melanoma antigen(MAGE)-A1, MAGE-A3 and New York esophageal cancer-1(NYESO-1), by reverse transcription PCR. Clinicopathological background information, such as gender, age, tumor size, macroscopic type, tumor histology, depth of invasion, lymph node metastasis, lymphatic invasion, venous invasion, and pathological stage, was obtained. Statistical comparisons between the expression of each CTA and each clinicopathological background were performed using the χ2 test. RESULTS The expression rates of KK-LC-1, MAGE-A1, MAGE-A3, and NY-ESO-1 were 79.5%, 32.5%, 39.8%, and 15.7%, respectively. In early stage gastric cancer specimens, the expression of KK-LC-1 was 79.4%, which is comparable to the 79.6% observed in advanced stage specimens. The expression of KK-LC-1 was not significantly associated with clinicopathological factors, while there were considerable differences in the expression rates of MAGE-A1 and MAGE-A3 with vs without lymphatic invasion(MAGE-A1, 39.3% vs 13.6%, P = 0.034; MAGE-A3, 47.5% vs 18.2%, P = 0.022) and/or vascular invasion(MAGE-A1, 41.5% vs 16.7%, P = 0.028; MAGE-A3, 49.1% vs 23.3%, P = 0.035) and, particularly, MAGE-A3, in patients with early vs advanced stage(36.5% vs 49.0%, P = 0.044), respectively. Patients expressing MAGE-A3 and NYESO-1 were older than those not expressing MAGE-A3 and NY-ESO-1(MAGE-A3, 73.7 ± 7.1 vs 67.4 ± 12.3, P = 0.009; NY-ESO-1, 75.5 ± 7.2 vs 68.8 ± 11.2, P = 0.042). CONCLUSION The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer. | Nobue Futawatari Takashi Fukuyama Rui Yamamura Akiko Shida Yoshihito Takahashi Yatsushi Nishi Yoshinobu Ichiki Noritada Kobayashi Hitoshi Yamazaki Masahiko Watanabe | 2017 | World Journal of Gastroenterology2017，23，46： | 3 |
| 6 | A slacks-based inefficiency measure for a two-stage system with bad outputs显示文摘 | Hirofumi Fukuyama William L. Weber | 2009 | Omega2009，，5： | 2 |
| 7 | The Post-Washington Consensus: Development After the Crisis显示文摘 | Birdsall Nancy Fukuyama Francis | 2011 | Foreign Affairs2011，，2： | 2 |
| 8 | Mucosal necrosis of the small intestine in myopathy,encephalopathy,lactic acidosis,and stroke-like episodes syndrome显示文摘This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with vomiting.Computed tomography showed portomesenteric venous gas and pneumatosis intestinalis.She underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial wall.Immunohistochemistry showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic mucosa.The microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine. | Keita Fukuyama Yasuhide Ishikawa Tetsuro Ogino Hidenobu Inoue Ryoya Yamaoka Tetsuro Hirose Tomohiko Nishihira | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 9 | The Efficiency and Productivity of Japanese Securities firms, 1988--1993 显示文摘 | Fukuyama Weber | 1999 | Japan and the World Economy1999，，11： | 1 |
| 10 | RuHCl( CO ) ( PPh3 ) 3 -catalyzed chemoselective transfer-hydrogenation of enones leading to saturated ketones 显示文摘 | Takahide D Fukuyama T Horiguchi J | 2006 | Synlett2006，，5： | 1 |
| 11 | Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium 显示文摘 | Miyazawa M Okuno Y Fukuyama M etal | 1999 | J AgricFoodChem1999，47，12： | 1 |
| 12 | Cerebral atrophy in pa- tients with lacunar infaltion and extensive leukoaraiosis 显示文摘 | Yamacuchi H Fukuyama H Ogawa M | 1994 | Stroke1994，25，9： | 1 |
| 13 | FRP composites in Japan 显示文摘 | Fukuyama H | 1999 | Concrete International ACI1999，21，10： | 1 |
| 14 | Essential role of the Fas-ligand in the development of hepatitis显示文摘 | Kondo T Suda T Fukuyama H | 1997 | Nat Med1997，3，4： | 1 |
| 15 | Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain 显示文摘 | Takizawa S Aratani Y Fukuyama N | 2002 | J CereBlood Flow Metab2002，22，1： | 1 |
| 16 | Pancreatic Ischemia Associated with Vasospasm in the Early Phase of Human Acute Necrotizing Pancreatitis显示文摘 | Takeda K Mikami Y Fukuyama S | 2005 | Pancreas2005，30，1： | 1 |
| 17 | Phosphate provides an extracelllular signal that drives nuclear export of Runx2/Cbfa1 显示文摘 | Fujita T Izumo N Fukuyama T | 2001 | Biochem Biophys Res Commun2001，280，1： | 1 |
| 18 | Cardiac remodeling and angiotensin Ⅱ-forming enzyme activity of the left ventricle in hamsters with chronic pressure overload induced by ascending aortic stenosis显示文摘 | Shimizu M Tanaka R Fukuyama T | 2006 | J Vet Med Sci2006，68，3： | 1 |
| 19 | Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity显示文摘 | Cicek M Fukuyama R Welch D R | 2005 | Cancer Res2005，65，9： | 1 |
| 20 | Investigation into bacteremia and spontaneous bacterial peritonitis in patients with liver cirrhosis in Japan显示文摘 | Shizuma T Fukuyama N | 2012 | Turk J Gastroenterol2012，23，2： | 1 |
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