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	题名	作者	年代	出处	被引量
1	Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC.	Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove	2014	World Journal of Gastroenterology2014，20，4：	2
2	The degree of nonlinearity and anisotropy of blood vessel elasticity显示文摘	ZHOU J FUNG YC	1997	Proc Natl Acad Sci USA1997，23，14：	2
3	Changes in the rheological properties of blood vessel tissue remodeling in the course of development of diabetes显示文摘	LIU SQ FUNG YC	1992	Biorheology1992，29，56：	2
4	Pseudoelasticity of arteries and the choice of its mathematical expression显示文摘	Fung YC Fronek K Patitucci P	1979	J Physiol1979，237，5：	2
5	Pseudoelasticity of arteries and the choice of its mathematical expression 显示文摘	Fung YC	1979	Am J Physiol1979，6，5：	1
6	Change of residual strains in arteries due to hypertrophy caused by aortic constrication显示文摘	Fung YC Liu SQ	1989	Circulation Research1989，65，：	1
7	Peristaltic carrying and mixing of chime in the small intestine(an analysis of a methodical model of peristalsis of the small intestine) 显示文摘	Lew HS Fung YC	1971	J Biotech1971，14，：	1
8	Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension 显示文摘	Mandegar M Fung YC Huang W	2004	Microvasc Res2004，68，2：	1
9	A variablestructure control with proportional and integral comperisations for electro--hydraulic position servo control system显示文摘	Fung RF Wang YC Yang RT etal	1997	Mechatronics1997，7，1：	1
10	Elementary mechanics of the endothelium of blood vessels 显示文摘	Fung YC Liu SQ	1993	J Biomech Eng1993，115，1：	1
11	Changes of zero-stress state of rat pulmonary arteries in hypoxic hypertension 显示文摘	Fung YC Liu SQ	1991	J Appl Physiol Respi Environ Excerc Physiol1991，70，6：	1
12	Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension 显示文摘	Mandegar M Fung YC Huang W	2004	Microvasc Res2004，68，2：	1
13	Analysis of Pig's coro-nary arterial blood flow with detailed anatomical ddata显示文摘	Berkley J Fung YC	1997	Ann bimed Eng1997，25，：	1
14	Cellular and molecular mechanisms of pulmonary vascular remodeling:role in the development of pulmonary hypertension显示文摘	Mandegar M Fung YC Huang W	2004	Microvasc Res2004，68，2：	1
15	Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the devel- opment of pulmonary hypertension显示文摘	Mandegar M Fung YC Huang W	2004	Microvasc Res2004，68，2：	1
16	Three-dimensional stress distribution in arteries显示文摘	Chuong CJ Fung YC	1983	Journal of Biomechanieal Engineering1983，105，：	1
17	Elementary mechanics of the endothelium of blood vessels显示文摘	Fung YC Liu SQ	1993	J Biomech Eng1993，115，：	1
18	On residual stresses in arteries显示文摘	Chuong CJ Fung YC	1986	Journal of Biomechanical Engineering1986，108，：	1
19	Mechanical properties of resting taenia coli smooth muscle显示文摘	Price JM Patitucci PJ Fung YC		0，，05：	1
20	Diameter-defined Strahler system and connectivity matrix of the pulmonary arterial tree显示文摘	Jiang Z Kassab GS Fung YC	1994	J Appl Physiol1994，76，：	1

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