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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Cloning and analysis of a Trichinella britovi gene encoding a cytoplasmic heat shock protein of 72 kDa显示文摘 | VAYSSIER M LE GUERHIER F FABIEN J F | 1999 | Parasitology1999，，： | 1 |
| 3 | Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration显示文摘 | Fabien LG Raphaelle G Philippos M | 2012 | J Cell Biol2012，198，5： | 1 |
| 4 | Clo-ning and analysis of a Trichinella britovi gene encoding a cy-toplasmic heat shock protein of 72ku显示文摘 | VAYSSIER M LE-GUERHIER F FABIEN J F | 1999 | Parasitology1999，119，1： | 1 |
| 5 | Treatment ofdomestic wastewater by an hydroponic NFT system显示文摘 | NATHALIE V FABIEN M HUGUETE S | 2003 | Chem-osphere2003，50，1： | 1 |
| 6 | The Bcl-2 family reunion 显示文摘 | Jerry EC Tudor M Fabien L | 2010 | Mol Cell2010，37，3： | 1 |
| 7 | Cloning and analysis of a Trichinella britovi gene encoding a cytoplasmic heat shock protein of 72KD显示文摘 | Vayssier M Le Guerhier F Fabien J F | 1999 | Parasitology1999，119，： | 1 |
| 8 | Semantic Web technologies to reconcile privacy and context awareness显示文摘 | Fabien L Gandon Norman M Sadeh | 2004 | Journal of Web Semantics2004，1，3： | 1 |
| 9 | Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters显示文摘 | FATIMA T FABIEN M JOELLE E | 2009 | Anal Bioanal Chem2009，393，67： | 1 |
| 10 | Magnetic nanop- article design for medical diagnosis and therapy显示文摘 | Stphane M Sbastien V Fabien G | 2004 | J Ma- ter Chem2004，，14： | 1 |
| 11 | Heavy metal contamination along a soil transect in the vicinity of the iron smelter of Kremikovtzi (Bulgaria) 显示文摘 | Rainer S Fabien C Margarita M | 2007 | Geoderma2007，140，： | 1 |
| 12 | SPME - GCMS study of the natural attenuation of aviation diesel spilled on the perennial ice cover of Lake Fryxell, Antarctica 显示文摘 | Caroline M B Jaraula Fabien Kenig Peter T Doran | 2008 | Science of The Total Environment2008，407，1： | 1 |
| 13 | Methods for synthesizing diethyl carbonate from ethanol and supercritical carbon dioxide by one-pot or two-step reactions in the presence of potassium carbonate显示文摘 | Fabien G Sophie T R Zephirin M | 2009 | The Journal of Supercritical Fluids2009，50，1： | 1 |
| 14 | Growth and irreversible pollution:are emission permits a means of avoiding environmental and poverty traps显示文摘 | Fabien P Alain J M Mabel T | 2013 | Macroeconomic Dynamics2013，17，2： | 1 |
| 15 | Linking functional diversity and social actor strategies in a frame- work for interdisciplinary analysis of nature's benefits to society显示文摘 | Sandra Diaz Fabien Qu6tier Daniel M Cdceres | 2011 | PNAS2011，108，3： | 1 |
| 16 | Cloning and analysis of a Trichinella briotovi gene encoding a cytoplasmic heat shock protein of 72 kD显示文摘 | Vayssier M Legnerhier F Fabien J F | 1999 | Parasitology1999，119，： | 1 |
| 17 | Heterodimers of G protein-coupled receptors as novel and distinct drug targets 显示文摘 | Rozenfeld R Fabien M D Adriaan P I | 2006 | Drug Discov Today : Ther Strat2006，3，4： | 1 |
| 18 | Adefovir dipivoxil is effective for the treatment of cirrhotic patients with lamivudine failure显示文摘 | FABIEN Z PARVIZ P PATRICK M | 2008 | Liver Int2008，67，10： | 1 |
| 19 | Characterization of eleven antigenic groups in Trichinella genus and identification of stage and species markers显示文摘 | Boireau P Vayssier M Fabien JF | 1997 | Parasitology1997，115，： | 1 |
| 20 | Occurrence and fate of antibiotics in the Seine River in various hydrological conditions显示文摘 | FATIMA T FABIEN M BARBARA L B | 2008 | Science of the Total Environment2008，393，1： | 1 |
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