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| 1 | Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice显示文摘Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles(NFTs); these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone(TIB) have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB(0.01 mg/kg and 1 mg/kg, intragastrically for 12 weeks) on the content of total and hyperphosphorylated Tau(PHF-1) proteins and the regulation of GSK3β/Akt/PI3 K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3 K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB: it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3 K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes. | Teresa Neri-Gomez Judith Espinosa-Raya Sofia Diaz Cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan Manuel Gallardo Christian Guerra-Araiza | 2017 | Neural Regeneration Research2017，12，4： | 12 |
| 2 | Linking functional diversity and social actor strategies in a frame- work for interdisciplinary analysis of nature's benefits to society显示文摘 | Sandra Diaz Fabien Qu6tier Daniel M Cdceres | 2011 | PNAS2011，108，3： | 1 |
| 3 | Hematopoiesis-related microRNA expression in myelodysplastic syndromes显示文摘 | Aina Pons Benet Nomdedeu Alfons Navarro Anna Gaya Bernat Gel Tania Diaz Sandra Valera Marí a Rozman Mohamed Belkaid Emili Montserrat Mariano Monzo | 2009 | Leukemia & Lymphoma2009，，11： | 1 |
| 4 | The role of select- ed cytochrome P450 enzymes on the bioactivation of aflatoxin B1 by duck liver microsomes 显示文摘 | DIAZ J MURCIA W SANDRA M | 2010 | Avian Pathology2010，39，4： | 1 |
| 5 | Leaf Traits as Indicators of Resource-Use Strategy in Foras with Succulent Species 显示文摘 | FERNANDA VENDRAMINI SANDRA DIAZ | 2002 | The New phytologist2002，154，1： | 1 |
| 6 | A Handbook of Protocols for Standardized and Easy Meas- urement of Plant Functional Traits Worldwide 显示文摘 | CORNELISSEN J H C SANDRA DIAZ DIEGO E | 2003 | Australian Journal of Botany2003，51，4： | 1 |
| 7 | Preparation and characterization of phosphate-modified mesoporous TiO2 incorporated in a silica matrix and their photocatalytic properties in the photodegradation of Congo red显示文摘 | Alberto ESTRELLA GONZALEZ Maximiliano ASOMOZA Ulises ARELLANO Sandra CIPAGAUTA DiAZ Silvia SOLíS | 2017 | Frontiers of Materials Science2017，11，3： | 0 |
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