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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Sepsis stimulates nonlysosomal,energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle显示文摘 | Tiao G Fagan J M Samuels N | 1994 | J Clin Invest1994，94，： | 2 |
| 3 | SOX2,a persistent marker for multipotential neural stem cells derived from embryonic stem cells,the embryo or the adult显示文摘 | Ellis P Fagan B M Magness S T | | 0，，24： | 2 |
| 4 | Porewater distribution and benthic flux measurements of mercury and methylmercury in the Gulf of Trieste (Northern Adriatic Sea)显示文摘 | Covelli S Faganeli J Horvat M | 1999 | Estuarine Coastal and Shelf Science1999，48，： | 1 |
| 5 | A comparison-shopper's guide to connectivity metrics显示文摘 | CALABRESE J M FAGAN W F | 2004 | Frontiers in Ecology and the Environment2004，2，10： | 1 |
| 6 | Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension 显示文摘 | Oka M Fagan KA Jones PL | 2008 | British J Pharmacol2008，155，4： | 1 |
| 7 | Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho - kinase 显示文摘 | FAGAN K A OKA M BAUER N R | 2004 | Am J Physiol Lung Cell Mol Physiol2004，287，4： | 1 |
| 8 | Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension显示文摘 | OKA M FAGAN KA JONES PL | 2008 | Br J Pharmacol2008，155，4： | 1 |
| 9 | Macrophage activating factor (s) secreted by mitogen stimulated goldfish kidney leucocytes syncrgize with bacterial lipopolysaccharide to induce nitric oxide production in tclcost macrophages 显示文摘 | Neumann N F Fagan D Bclosevic M | 1995 | Dev Comp Immunol1995，19，47： | 1 |
| 10 | Disposition Kinetic of ropivacaine in humans显示文摘 | Lee A Fagan D Lamont M | 1989 | Anesth Analg1989，67，6： | 1 |
| 11 | Attenuation of acute hypoxicpulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase显示文摘 | Fagan KA Oka M Bauer NR | 2004 | Am J Physiol Lung Cell MolPhysiol2004，287，4： | 1 |
| 12 | Mercury in Contaminated Coastal Environments:A Case Study:The Gulf of Trieste显示文摘 | Horvat M Covelli S Faganeli J | 1999 | The Science of the Total Environment1999，，： | 1 |
| 13 | Human and murine APOE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimerg disease显示文摘 | Fagan AM Watson M parsadanian M | 2002 | Neurobiol Dis2002，9，3： | 1 |
| 14 | Phase distribution identification in the column leaching of low grade ores using MRI显示文摘 | FAGAN M A SEDERMAN A J HARRISON S T L JOHNS M L | 2013 | Minerals Engineering2013，48，： | 1 |
| 15 | Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase显示文摘 | Fagan KA Oka M Bauer NR | 2004 | Am J Physiol Lung Cell Mol Physiol2004，287，4： | 1 |
| 16 | A Mouse Model for Beta Cell-Specific Ablation of Target Gene(s) Using the Cre-loxP System 显示文摘 | Ray M K Fagan S P Moldovan S | 1998 | Biochemical and Biophysical Research Communications1998，253，1： | 1 |
| 17 | Total mercury and methylmercury and selenium in mercury polluted areas in Guizhou Province,China显示文摘 | Horvat M Nolde N Fajon V Jereb V Logar M Lojen S Jacimovic R Falnoga I Qu Liya Faganeli J DrobneD | 2003 | Science of Total Environment2003，304，： | 1 |
| 18 | Sulfur isotope systematics and platinum group elements behavior in REE-enriched metasomatic fluids: A study of mantle xenoliths from Dish Hill, California, USA显示文摘 | WILSON M R KYESER T K FAGAN R | 1996 | Geochim Cosmochim Acta1996，61，： | 1 |
| 19 | Identifying new tran- scriptional targets for SRC - 1 in breast cancer 显示文摘 | McCartan DP Mcllroy M Fagan A | 2010 | Irish J Med Sci2010，179，9： | 1 |
| 20 | Hypoxia-induced pulmonary vascular remodeling:cellular and molecular mechanisms显示文摘 | Stenmark K R Fagan K A Frid M G | 2006 | Circ Res2006，99，7： | 1 |
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