|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 2 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 3 | Knowledge, perception and practices about malaria, climate change, livelihoods and food security among rural communities of central Tanzania显示文摘Background:Understanding the interactions between malaria and agriculture in Tanzania is of particular significance when considering that they are the major sources of illness and livelihoods.The objective of this study was to determine knowledge,perceptions and practices as regards to malaria,climate change,livelihoods and food insecurity in a rural farming community in central Tanzania.Methods:Using a cross-sectional design,heads of households were interviewed on their knowledge and perceptions on malaria transmission,symptoms and prevention and knowledge and practices as regards to climate change and food security.Results:A total of 399 individuals(mean age=39.8±15.5 years)were interviewed.Most(62.41%)of them had attained primary school education and majority(91.23%)were involved in crop farming activities.Nearly all(94.7%)knew that malaria is acquired through a mosquito bite.Three quarters(73%)reported that most people get sick from malaria during the rainy season.About 50%of the respondents felt that malaria had decreased during the last 10 years.The household coverage of insecticide treated mosquito nets(ITN)was high(95.5%).Ninety-six percent reported to have slept under a mosquito net the previous night.Only one in four understood the official Kiswahili term(Mabadiliko ya Tabia Nchi)for climate change.However,there was a general understanding that the rain patterns have changed in the past 10 years.Sixty-two percent believed that the temperature has increased during the same period.Three quarters of the respondents reported that they had no sufficient production from their own farms to guarantee food security in their household for the year.Three quarters(73.0%)reported to having food shortages in the past five years.About half said they most often experienced severe food shortage during the rainy season.Conclusion:Farming communities in Kilosa District have little knowledge on climate change and its impact on malaria burden.Food insecurity is common and community-based strategies to mitigate this need to be established.The findings call for an integrated control of malaria and food insecurity interventions. | Benjamin K Mayala Carolyn A Fahey Dorothy Wei Maria M Zinga Venera M Bwana Tabitha Mlacha Susan F Rumisha Grades Stanley Elizabeth H Shayo Leonard EG Mboera | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 4 | Selected fructooligosaccharide (l-kestose,nystose,and 1F-β-fructofuranosylnystose) composition of foods and feeds显示文摘 | CAMPBELL J M BAUER L L FAHEY G C | 1997 | Journal of Agricultural and Food Chemistry1997，45，8： | 1 |
| 5 | Sex Hormone Regulation of Innate Immunity in the Female Reproductive Tract:The Role of Epithelial Cells in Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens显示文摘 | Wira CR Fahey JV Ghosh M | | 0，，06： | 1 |
| 6 | Soil freezing alters fine root dynamics in a northern hardwood forest 显示文摘 | Tierney G L Fahey T J Groffman P M | 2001 | Biogeochem- istry2001，56，2： | 1 |
| 7 | A new dominantly inherited pure cerebellar ataxia, SCA30显示文摘 | Storey E Bahlo M Fahey MC | 2009 | J Neurol Neurosurg Psychiatry2009，80，： | 1 |
| 8 | Bone tunnel enlargement after anterior cruciate ligament replacement显示文摘 | Fahey M Indelicato PA | 1994 | Am J Sports Med1994，22，3： | 1 |
| 9 | Comparative effects of infrared and one-third hot-blade trimming on beak to- pography, behavior, and growth 显示文摘 | Marchant-Forde R M Fahey A G Cheng H W | 2008 | Poultry Science2008，87，8： | 1 |
| 10 | Deformation of granular materials due to rotation of principal axes显示文摘 | JOER H A LANIER J FAHEY M | 1998 | Geoteehnique1998，48，5： | 1 |
| 11 | Numerical modeling of cemented mine backfill deposition显示文摘 | Helinski M Fahey M Fourie A | | 0，，10： | 1 |
| 12 | An enteral formula containing fish oil, Iindigestible oligosaccharides, gum arabic and antioxidants affects plasma and colonic phospholipid fatty acid and prostaglandin profiles in pigs显示文摘 | Campbell J M Fahey G C Jr Lichtensteige | 1997 | J Nutr1997，127，1： | 1 |
| 13 | Meta-analytic methods for diagnostic test accuracy显示文摘 | Irwig L Macaskill P Glasziou P Fahey M | 1995 | J Clin Epidemiol1995，48，： | 1 |
| 14 | Consolidation in accreting sediments:Gibson's solution applied to backfilling of mine stopes显示文摘 | Fahey M Helinski M Fourie A | 2010 | Géotechnique2010，，11： | 1 |
| 15 | Deformation of granular materials due to rotation of principal axes显示文摘 | JOER H A LANIER J FAHEY M | 1998 | Geoteehnique1998，48，5： | 1 |
| 16 | Development of specimen curing procedures that account for the influence of effective stress during curing on the strength of cemented mine backfill显示文摘 | Fahey M Helinski M Fourie A | | 0，，： | 1 |
| 17 | The pathogenesis of Schmorl′s nodes in relation to acute trauma:an autopsy study显示文摘 | Opeskin K Silberstein M | 1998 | Spine1998，23，： | 1 |
| 18 | Sex Hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens 显示文摘 | Wira CR Fahey JV Ghosh M | 2010 | Am J Re-prod Immunol2010，63，6： | 1 |
| 19 | Effect s of mild winter freezing on soil nitrogen and carbon dynamics in a north- em hardwood forest显示文摘 | Grofman P M Driscoll C T Fahey T J | 2001 | Biogeochemistry2001，56，： | 1 |
| 20 | Bone tunnel enlargement after ACL allograft reconstruction显示文摘 | Fahey M Indelicato P | | 0，，03： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员