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    题名 作者 年代 出处 被引量
1强化竹叶提取物对麦乳精抗氧化性能的改进显示文摘本研究在麦乳精(阿华田)中强化竹叶提取物(Ebl972),以期能显著改进制品的抗自由基和抗氧化能力,并保护其中VA和VE的活性。方法和结果:(1)通过感官评定得出在阿华田中强化1%的EBI972是适宜的;(2)用化学发光法测定阿华田清除活性氧自由基的能力,表明强化样清除O_2和OH的能力分别是对照的2.4和1.6倍;(3)用硫代巴比妥酸法测定其抗油脂氧化的能力,表明强化后有了极显著的提高;(4)将试样保存在50±1℃,22d后分别测定VA和VE含量,表明强化样中的损失量显著少于对照。结论:竹叶提取物不仅是一种优良的生物黄酮类保健功能因子,同时还是很具潜力的食品抗氧化剂,在麦乳精中的应用除了赋予产品的保健功能外,还能显著改进产品的商品性能。张英 吴晓琴 傅小伟 Faisal H.A.Othman 2001食品科学2001,22,6:16
2Three-dimensional hierarchical Pt-Cu superstructures显示文摘三维(3D ) 层次 Pt-Cu 四角形,高度分叉,并且树枝状的上层建筑被一条灵巧的没有模板的热水的途径综合了,出现生长模式沿着(111, 110 ) ,(111 ) ,并且(100 ) 飞机分别地。这些结构被传播电子显微镜学( TEM )描绘了,X光检查衍射( XRD ),精力散X光检查光谱学( EDX ),诱导地联合的血浆光排放 spectrometry ( ICP-OES )和详细形成机制被开发了,它证明在里面形成的 situ 我<潜水艇class=“ a-plus-plus ”>在 Cu 和磅之间的 2 和流电的代替反应<啜class=“ a-plus-plus ”>4+可以指导这些上层建筑的形成。比较 electrocatalytic 性质为甲醇和乙醇氧化被调查了。由于他们的互连的手臂,足够的吸收地点,和暴露的表面,这些上层建筑展览为甲醇和乙醇的电镀物品氧化提高了 electrocatalytic 性能什么时候与商业 Pt/C 和磅黑色相比。Farhat Nosheen Zhicheng Zhang Guolei Xiang Biao Xu Yong Yang Faisal Saleem Xiaobin Xu Jingchao Zhang Xun Wang 2015Nano Research2015,8,3:14
3Preoperative selection of patients with colorectal cancerliver metastasis for hepatic resection显示文摘Surgical resection of colorectal liver metastases(CRLM) has a well-documented improvement in survival. To benefit from this intervention, proper selection of patients who would be adequate surgical candidates becomes vital. A combination of imaging techniques may be utilized in the detection of the lesions. The criteria for resection are continuously evolving; currently, the requirements that need be met to undergo resection of CRLM are: the anticipation of attaining a negative margin(R0 resection), whilst maintaining an adequate functioning future liver remnant. The timing of hepatectomy in regards to resection of the primary remains controversial; before, after, or simultaneously. This depends mainly on the tumor burden and symptoms from the primary tumor. The role of chemotherapy differs according to the resectability of the liver lesion(s); no evidence of improved survival was shown in patients with resectable disease who received preoperative chemotherapy. Presence of extrahepatic disease in itself is no longer considered a reason to preclude patients from resection of their CRLM, providing limited extra-hepatic disease, although this currently is an area of active investigations. In conclusion, we review the indications, the adequate selection of patients and perioperative factors to be considered for resection of colorectal liver metastasis.Rafif E Mattar Faisal A Al-alem Eve Simoneau Mazen Hassanain 2016World Journal of Gastroenterology2016,22,2:13
4Synthesis of an AIE-active fluorogen and its application in cell imaging显示文摘A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor.LAM Jacky Wing Yip FAISAL Mahtab NG Ka Ming LUO Kathy Qian 2009Science China Chemistry2009,52,1:12
5新疆塔什库尔干野生动物自然保护区马可波罗盘羊潜在生态廊道识别显示文摘识别野生动物的适宜生境并在适宜生境之间构建生态廊道能够提高生境连通性,有利于加强种群间基因交流并缓解生境破碎化带来的不利影响。本研究基于生境适宜性评价结果确定了塔什库尔干野生动物自然保护区内马可波罗盘羊(Ovis polii)的核心生境斑块,运用廊道设计模型Linkage Mapper识别最低成本廊道并确定其优先级。结果表明,马可波罗盘羊适宜生境主要分布在保护区西北部,核心生境斑块少且破碎化明显,夏冬两季核心生境斑块均为28个,潜在生态廊道分别为45和47条。采用成本加权距离与欧几里得距离之比(CWD:EucD)以及成本加权距离与最低成本路径长度之比(CWD:LCP)两种度量方法评估了生态廊道的质量与重要性。以CWD:EucD来衡量,夏季质量最高的4条廊道分别是皮斯岭至帕日帕克、同库至马尔洋、科克吐鲁克至帕日帕克,以及哈尔努孜至同库;冬季质量最高的3条廊道分别是其克尔克尔至亚希洛夫、萨提曼至依西代尔、其克尔克尔至科克吐鲁克。CWD:LCP分析表明,夏季质量最高的廊道分别是哈尔努孜至阔克加尔和阔克加尔至马尔洋;冬季质量最高的廊道分别是爱勒米希至塔萨拉、沙尔比列西南至依西代尔。利用流中心性评估各核心生境斑块和廊道的重要性表明,帕日帕克、塔萨拉和马尔洋这三个斑块在促进马可波罗盘羊迁移扩散方面的贡献值最高。夏季皮斯岭至帕日帕克、同库至马尔洋和马拉特至其克尔克尔这3条廊道的贡献值最高;冬季爱勒米希至塔萨拉、沙尔比列至沙尔比列西南和铁尔布尔列至沙尔比列这3条廊道的贡献值最高,上述核心生境斑块和生态廊道在维持保护区马可波罗盘羊种群迁徙扩散中发挥着关键作用。此外,赞坎、沙尔比列等斑块虽然面积小、贡献值低,但起到了维持景观中重要斑块连通的踏脚石作用,其重要性也不可忽略。研究结果可为塔什库尔干野生动物保护区马可波罗盘羊有效保护、保护区功能区划优化以及当地基础建设项目的规划选址提供科学指导。陈强强 李美玲 王旭 Faisal Mueen Qamer 王鹏 杨建伟 汪沐阳 杨维康 2019生物多样性2019,27,2:10
6Role of ZnO-CeO_2 Nanostructures as a Photo-catalyst and Chemi-sensor显示文摘ZnO-CeO2 nanostructures were synthesized by simple and effcient low temperature method. The structure and morphology of the ZnO-CeO2 nanostructures were characterized by X-ray powder diffraction (XRD) and field emission scanning electron microscopy (FESEM), which revealed elongated shaped CeO2 nanoparticles with diameters of 40-90 nm distributed on the surface of elongated ZnO nanostructures with diameters of 50-200 nm (edge-centre). Further the structure of the synthesized ZnO-CeO2 nanostructure was supported by Raman spectra and Fourier transform infrared spectroscopy (FTIR). UV-vis absorption spectrum was used to confirm the optical properties of the CeO2 doped ZnO nanostructures. Photo-catalytic activity of CeO2 doped ZnO nanostructure was evaluated by degradation of acridine orange and methylene blue which degraded 84.55% and 48.65% in 170 min, respectively. ZnO-CeO2 nanostructures also showed good sensitivity (0.8331 μA·cm-2·(mol/l)-1) in short response time (10 s) by applying to chemical sensing using ethanol as a target compound by I-V technique. These degradation and chemical sensing properties of ZnO-CeO2 nanostructures are of great importance for the application of ZnO-CeO2 system as a photo-catalyst and chemical sensor.M. Faisal Sher Bahadar Khan Mohammed M. Rahman Aslam Jamal Kalsoom Akhtar M.M. Abdullah 2011Journal of Materials Science & Technology2011,27,7:9
7Assessment of knowledge, attitude and practice regarding oxygen therapy at emergency departments in Riyadh in 2017: A cross-sectional study显示文摘BACKGROUND: Administering oxygen therapy(OT) has an essential role in preventing/managing hypoxemia in both acute and chronic conditions. It should be adjusted to achieve the normal oxygen saturation of 94%–98% in most cases. This study aims to evaluate knowledge, attitude and practice(KAP) of nurses, paramedics, emergency medical technicians(EMTs) and Emergency Medical Services(EMS) physicians working at emergency departments(ED) in Riyadh, Saudi Arabia. METHODS: In this cross-sectional study, a structured questionnaire was used to assess KAP related to OT of nurses, paramedics, EMTs and EMS physicians currently working at an ED of a tertiary care hospital. Knowledge and attitude were assessed using a Likert scale from 1–5, whereas practice was assessed as a yes/no categorical variable.RESULTS: A total of 444 emergency health-care workers(EHCWs) participated, of which 225(50.7%) were male, with the majority(77%) in the age group of 20–35 years. Over half of the sample were nurses(266; 59.9%). The mean score for knowledge about OT was 5.51±1.45, attitude was 26.31±3.17 and for practices 4.55±1.76. The main factors which were associated with poor KAP were workload and lack of local guidelines. The distribution of overall practice score was signifi cantly better among paramedics – nurses group and EMT – nurses group.CONCLUSION: This study demonstrates that there is a gap in EHCWs' KAP, particularly regarding when to provide OT to a patient. This gap can affect patients' safety. Extensive educational and training programs about OT are needed to raise awareness among health-care providers.Amairah Fahad Aloushan Faisal Abdullah Almoaiqel Raid Naysh Alghamdi Fatmah Ismail Alnahari Abdulaziz Fahad Aldosari Nazish Masud Nawfal Abdullah Aljerian 2019World Journal of Emergency Medicine2019,10,2:8
8Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies.Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh 2006World Journal of Gastroenterology2006,12,43:7
9Multilevel Pattern Mining Architecture for Automatic Network Monitoring in Heterogeneous Wireless Communication Networks显示文摘The rapid development of network technology and its evolution toward heterogeneous networks has increased the demand to support automatic monitoring and the management of heterogeneous wireless communication networks.This paper presents a multilevel pattern mining architecture to support automatic network management by discovering interesting patterns from telecom network monitoring data.This architecture leverages and combines existing frequent itemset discovery over data streams,association rule deduction,frequent sequential pattern mining,and frequent temporal pattern mining techniques while also making use of distributed processing platforms to achieve high-volume throughput.Zhiguo Qu John Keeney Sebastian Robitzsch Faisal Zaman Xiaojun Wang 2016China Communications2016,13,7:7
10基于模糊语言变量的动态目标无线网络选择技术(英文)显示文摘Even though various wireless Network Access Technologies(NATs)with different specifications and applications have been developed in the recent years,no single wireless technology alone can satisfy the anytime,anywhere,and any service wireless-access needs of mobile users.A real seamless wireless mobile environment is only realized by considering vertical and horizontal handoffs together.One of the major design issues in heterogeneous wireless networks is the support of Vertical Handoff(VHO).VHO occurs when a multi-interface enabled mobile terminal changes its Point of Attachment(PoA)from one type of wireless access technology to another,while maintaining an active session.In this paper we present a novel multi-criteria VHO algorithm,which chooses the target NAT based on several factors such as user preferences,system parameters,and traffic-types with varying Quality of Service(QoS)requirements.Two modules i.e.,VHO Necessity Estimation(VHONE)module and target NAT selection module,are designed.Both modules utilize several'weighted'users’and system’s parameters.To improve the robustness of the proposed algorithm,the weighting system is designed based on the concept of fuzzy linguistic variables.Faisal Kaleem Abolfazl Mehbodniya Arif Islam Kang K.Yen Fumiyuki Adachi 2013China Communications2013,10,1:6
11Comparative assessment of total polyphenols, antioxidant and antimicrobial activity of different tea varieties of Bangladesh显示文摘Objective: To determine the total polyphenol content, antioxidant activity and antibacterial properties of the extracts of different Bangladeshi tea varieties such as flowery broken orange pekoe, broken orange pekoe, red dust and green tea.Methods: Total phenolic and flavonoid contents were determined by Folin–Ciocalteu and aluminum chloride colorimetric assay, respectively.The antioxidant capacity was determined by ferric ion reducing antioxidant power and phosphomolybdenum method.Antibacterial activity was evaluated by disc diffusion method in agar plate and subsequently, the minimum inhibitory concentration was determined by broth dilution method.Results: Total phenolic and flavonoid contents were significantly higher(P < 0.05) in green tea compared to other three black tea varieties.The green tea also showed a higher free radical scavenging and antioxidant activities than all the other tea varieties tested(P < 0.05).In addition, the extracts of all four tea varieties showed inhibitory activity against several pathogenic bacteria and also the same trend of higher antimicrobial activity of green tea than other tea varieties was observed.Conclusions: Taken together, the results of this study demonstrated that Bangladeshi tea,especially the green tea, may act as a substitute for natural antioxidants and as a promising antibacterial agent for beneficial influence in human health.Yead Morshed Nibir Ahmed Faisal Sumit Anwarul Azim Akhand Nazmul Ahsan Mohammad Shahnoor Hossain 2017Asian Pacific Journal of Tropical Biomedicine2017,7,4:6
12Design and Optimization of Segmented PM Consequent Pole Hybrid Excited Flux Switching Machine for EV/HEV Application显示文摘Hybrid Excited Flux Switching Machines(HEFSMs)unique feature of high torque density(T_(den))of Permanent Magnet(PM)machines and flux regulation capability of wound field excitation machines.Due to aforesaid unique features,stator active HEFSMs are preferred for EV/HEV applications.In this paper a new Segmented PM Consequent Pole HE-FSM(SPMCPHEFSM)with flux bridge is proposed for EV/HEV.The developed SPMCPHEFSM exhibits improved flux modulation and flux regulation capability at reduced PM usage(suppressed PM volume by 46.52%and PM cost by 46.48%)and eliminating stator leakage flux.First,SPMCPHEFSM is geometric optimized(GO)for investigating influence of leading design with key performance indicators such as flux linkage(Ф_(pp)),average torque(T_(avg)),cogging torque(T_(cog)),T_(den),average power(P_(avg))and power density(P_(den))and then proceeded optimized model to structure modification for optimal stator design and position of field excitation coils(FEC).Comprehensive performance analysis reveals that the developed SPMCPHEFSM show improvedФ_(pp)maximum up to 9.11%,improved T_(avg)maximum up to 23.63%,truncate T_(cog)up to 18.9%whereas T_(den)and P_(den)are boost up to 23.55%and 89.72%respectively.Wasiq Ullah Faisal Khan Muhammad Umair 2020CES Transactions on Electrical Machines and Systems2020,4,3:6
13A review of recent advancements in finite element formulation for sandwich plates显示文摘Use of composite structures is exponentially growing in different fields due to their higher strength-to-weight ratio. This application trend requires that accurate theoretical explanations and their finite element models be developed for analyzing sandwich plates before finalizing the designs. This paper reviews the recent research trends of finite element formulations developed for analyzing sandwich plates. This paper reviews the finite element models developed after the year 2000. Initially, the finite element formulations based on first order shear deformation theory, higher order shear deformation theories, mixed solid-shell elements, zig-zag theories and global–local theories are presented. Then, some finite element formulations developed to analyze a very new class of structures called piezoelectric structures are presented. At the end, some formulations to analyze a very critical phenomenon called buckling are presented.Shehzaib IRFAN Faisal SIDDIQUI 2019Chinese Journal of Aeronautics2019,32,4:5
14A Survey on Fault Diagnosis and Fault Tolerant Methodologies for Permanent Magnet Synchronous Machines显示文摘This paper presents a comprehensive survey of fault diagnosis and fault tolerant approaches for permanent magnet synchronous machines(PMSM).PMSMs are prominent in the pervading usage of electric motors,for their high efficiency,great robustness,reliability and low torque inertia.In spite of their extensive appliance,they can be quite non-resilient and inadequate in operation when faults appear in motor drive apparatus such as inverters,stator windings,sensors,etc.These may lead to insulation failure,torque fluctuations,overcurrent or even system collapse.On that account,fault diagnosis and fault tolerant methods are equipped to enhance the stability and robustness in PMSMs.Progressive methodologies of PMSM fault diagnosis and tolerance are classified,discussed,reviewed and compared in this paper,beginning with mat hematical modeling of PMSM and then scrutinizing various fault conditions in PMSMs.Finally,the scope of research on the topic is highlighted.The contribution of this review is to emphasize optimistic schemes and to assist researchers with the latest trends in this field for future directions.Erphan A.Bhuiyan Md.Maeenul Azad Akhand Sajal K.Das Md.F.Ali Z.Tasneem Md.R.Islam D.K.Saha Faisal R.Badal Md.H.Ahamed S.I.Moyeen 2020International Journal of Automation and computing2020,17,6:5
15Clinical update on the management of pseudopapillary tumor of pancreas显示文摘Solid pseudopapillary neoplasm(SPN) is a rare tumor with malignant potential which is generally located in the tail of pancreas.The prevalence of SPN has increased with widespread use of cross sectional imaging.SPN is often misdiagnosed due to nonspecific clinical presentation and accurate diagnosis is essential for optimal management.Endoscopic ultrasound-FNA with immunohistochemistry can help in preoperative diagnosis.Surgery is the treatment of choice and a successful R0 resection is curative.Overall,SPN has a good prognosis.This review article focuses on pathogenesis,diagnosis and management of SPN.Gandhi Lanke Faisal S Ali Jeffrey H Lee 2018World Journal of Gastrointestinal Endoscopy2018,10,9:5
16Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis.Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo 2007World Journal of Gastroenterology2007,13,29:5
17Entropy analysis in electrical magnetohydrodynamic(MHD) flow of nanofluid with effects of thermal radiation,viscous dissipation,and chemical reaction显示文摘The unsteady mixed convection flow of electrical conducting nanofluid and heat transfer due to a permeable linear stretching sheet with the combined effects of an electric field, magnetic field, thermal radiation, viscous dissipation, and chemical reaction have been investigated. A similarity transformation is used to transform the constitutive equations into a system of nonlinear ordinary differential equations.The resultant system of equations is then solved numerically using implicit finite difference method.The velocity, temperature, concentration, entropy generation, and Bejan number are obtained with the dependence of different emerging parameters examined. It is noticed that the velocity is more sensible with high values of electric field and diminished with a magnetic field. The radiative heat transfer and viscous dissipation enhance the heat conduction in the system. Moreover, the impact of mixed convection parameter and Buoyancy ratio parameter on Bejan number profile has reverse effects. A chemical reaction reduced the nanoparticle concentration for higher values.Yahaya Shagaiya Daniel Zainal Abdul Aziz Zuhaila Ismail Faisal Salah 2017Theoretical & Applied Mechanics Letters2017,7,4:5
18An optimized industry processing technology of peanut tofu and the novel prediction model for suitable peanut varieties显示文摘Peanut protein is easily digested and absorbed by the human body,and peanut tofu does not contain flatulence factors and beany flour.However,at present,there is no industrial preparation process of peanut tofu,whereas the quality of tofu prepared by different peanut varieties is quite different.This study established an industrial feasible production process of peanut tofu and optimized the key process that regulates its quality.Compared with the existing method,the production time is reduced by 53.80%,therefore the daily production output is increased by 183.33%.The chemical properties of 26 peanut varieties and the quality characteristics of tofu prepared from these 26 varieties were determined.The peanut varieties were classified based on the quality characteristics of tofu using the hierarchical cluster analysis(HCA)method,out of which 7 varieties were screened out which were suitable for preparing peanut tofu.An evaluation standard was founded based on peanut tofu qualities.Six chemical trait indexes were correlated with peanut tofu qualities(P<0.05).A logistic regressive model was developed to predict suitable peanut varieties and this prediction model was verified.This study may help broaden the peanut protein utilization,and provide guidance for breeding experts to select certain varieties for product specific cultivation of peanut.CHEN Bing-yu LI Qi-zhai HU Hui MENG Shi Faisal SHAH WANG Qiang LIU Hong-zhi 2020Journal of Integrative Agriculture2020,19,9:5
19Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection:a Numerical Design-Based Analysis显示文摘This paper provides a simple hybrid design and numerical analysis of the graphene-coated fiber-optic surface plasmon resonance(SPR)biosensor for breast cancer gene-1 early onset(BRCA1)and breast cancer gene-2 early onset(BRCA2)genetic breast cancer detection.Two specific mutations named 916delTT and 6174delT in the BRCA1 and BRCA2 are selected for numerical detection of breast cancer.This sensor is based on the technique of the attenuated total reflection(ATR)method to detect deoxyribonucleic acid(DNA)hybridization along with individual point mutations in BRCA1 and BRCA2 genes.We have numerically shown that momentous changes present in the SPR angle(minimum:135%more)and surface resonance frequency(SRF)(minimum:136%more)for probe DNA with various concentrations of target DNA corresponding to a mutation of the BRCA1 and BRCA2 genes.The variation of the SPR angle and SRF for mismatched DNA strands is quite negligible,whereas that for complementary DNA strands is considerable,which is essential for proper detection of genetic biomarkers(916delTT and 6174delT)for early breast cancer.At last,the effect of electric field distribution in inserting graphene layer is analyzed incorporating the finite difference time domain(FDTD)technique by using Lumerical FDTD solution commercial software.To the best of our knowledge,this is the first demonstration of such a highly efficient biosensor for detecting BRCA1 and BRCA2 breast cancer.Therefore,the proposed biosensor opens a new window toward the detection of breast cancers.Md.Biplob HOSSAIN Md.Muztahidul ISLAM Lway Faisal ABDULRAZAK Md.Masud RANA Tarik Bin Abdul AKIB Mehedi HASSAN 2020Photonic Sensors2020,10,1:4
20Liver transplantation for hepatitis B virus: Decreasing indication and changing trends显示文摘AIM: To evaluate the indication and outcome of hepatitis B virus(HBV)-related liver transplantation(LT) in the era of newer antiviral agents.METHODS: We collected data on all patients who underwent transplantation at King Faisal Specialist Hospital and Research Center.These data included demographic,perioperative and long-term postoperative follow-up data including viral serological markers,HBV DNA,and repeated liver imaging.Between January 1990 and January 2012,133 patients(106 males and 27 females) underwent LT for HBV-related cirrhosis at our center.All patients were followed up frequently during the first year following transplantation,according to our standard protocol; follow-up visits occurred every 3-6 mo thereafter.Breakthrough infection was definedas re-emergence of HBV-DNA or hepatitis B surface antigen(HBs Ag) while on treatment.Five patients transplanted prior to 1992 did not receive immediate posttransplant anti-HBV prophylaxis; all other patients were treated with HBIG and at least one nucleos(t)ide analog.RESULTS: One hundred and thirty-three patients underwent LT for HBV and were followed for a median of 82 mo(range: 1-274).The rates of post-LT survival and HBV recurrence during the follow-up period were 89% and 11%,respectively.The following factors were associated with disease recurrence: younger age(44.3 ± 16.2 years vs 51.4 ± 9.9 years,P = 0.02),positive pretransplant hepatitis B e antigen(HBe Ag)(60% vs 14%,P < 0.0001),detectable pretransplant HBV DNA(60% vs 27%,P = 0.03),positive posttransplant HBs Ag(80% vs 4%,P < 0.0001) and positive posttransplant HBe Ag(27% vs 1%,P < 0.0001).Forty-four(33%) patients had hepatocellular carcinoma(HCC).In the first(pre-2007) group,HBV was the second leading indication for LT after hepatitis C virus infection.A total of 64 transplants were performed,including 46(72%) for decompensated HBV cirrhosis,12(19%) for decompensated cirrhosis complicated by HCC and 6(10%) for compensated cirrhosis complicated by HCC.In the second group,nonalcoholic steatohepatitis surpassed HBV as the second leading indication for LT.A total of 69 HBV related transplants were performed,including 43(62%) for decompensated HBV cirrhosis,7(10%) for decompensated cirrhosis complicated by HCC and 19(27.5%) for compensated cirrhosis complicated by HCC.There was a significant(P = 0.007) increase in the number of transplants for compensated cirrhosis complicated by HCC.CONCLUSION: The use of potent anti-HBV agents has led to a changing trend in the indications for LT.HBV is currently the third leading indication for LT in this hyperendemic area.Waleed Al-hamoudi Hussien Elsiesy Abdulrahman Bendahmash Nasser Al-masri Safiyya Ali Naglaa Allam Mohammed Al Sofayan Hamad Al Bahili Mohammed Al Sebayel Dieter Broering Sammy Saab Faisal Abaalkhail 2015World Journal of Gastroenterology2015,21,26:4
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