| 4 | Construction of the Hexacyclic Core of Dispirocochlearoids A-C via a Diels-Alder Reaction显示文摘The natural products of dispirocochlearoids are complex Ganoderma meroterpenoids featuring a 6/6/5/6/6/6 ring system and are selective cox-2 inhibitors.Herein,we describe our progress regarding the total synthesis of dispirocochlearoids A-C,in which a hexacyclic skeleton was constructed firstly.The key steps of this work involve an intermolecular[4+2]cycloaddition reaction,a ring cleavage approach via Ticla,and the installation of a profoundly sterically hindering lactone. | Qiang Fu Yonghui Wang Fajun Nan | 2022 | Chinese Journal of Chemistry2022，40，13： | 0 |
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