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| 1 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 2 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 3 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 4 | Multihop diversity in wireless relaying channels 显示文摘 | Boyer J Falconer D Yanikomeroglu H | 2004 | IEEE Trans Commun2004，52，10： | 1 |
| 5 | Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients显示文摘 | Bedaiwy M A Falcone T Goldberg J M | 2006 | Hum Reprod2006，21，： | 1 |
| 6 | Dimension and measure of quasi-self-similar sets显示文摘 | Falconer K J | 1989 | Proc Amer Math Soc1989，106，： | 1 |
| 7 | Nucleotide sequence, transcriptional analysis,and expression of genes encoded within the form I CO2 fixation operon of Rhodobacter sphaeroides显示文摘 | Gibson J L Falcone D L Tabita F R | 1991 | J Biol Chem1991，266，14： | 1 |
| 8 | Persistent bilateral ureteral obstruc- tion secondary to endometriosis despite treatment with an aroma- tase inhibitor 显示文摘 | Bohrer J Chen CC Falcone T | 2008 | Fertil Steril2008，90，： | 1 |
| 9 | Interpreting unary, binary, and ternary mixture permeation across a SAPO-34 membrane with loading-dependent Maxwell-Stefan diffusivities 显示文摘 | Li S Falconer J L Noble R D | 2007 | J Phys Chem C2007，111，： | 1 |
| 10 | Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro显示文摘 | Esfandiari N Falcone T Golderg J M | 2005 | Reprod Biomed Online2005，11，5： | 1 |
| 11 | Risk factors for computed tomography angiography spot sign in deep and lobar intracerebral hemorrhage are shared 显示文摘 | Radmanesh F Falcone G J Anderson C D | 2014 | Stroke2014，45，6： | 1 |
| 12 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 13 | Transparent thin-film TiO2 photocatalysts with high activity 显示文摘 | Blount M C Kim D H Falconer J L | 2001 | Environ Sci Technol2001，35，14： | 1 |
| 14 | Allostatie load is associated with chronic conditions in the Boston Puerto Rican health study显示文摘 | Mattei J Demissie S Falcon L | 2010 | Soe Sci Med2010，70，： | 1 |
| 15 | Focal dysplasia of the cerebral cortex in epilepsy 显示文摘 | Taylor DC Falconer MA Bruton C J | 1971 | J Neurol Neurosurg Psychiatry1971，34，4： | 1 |
| 16 | Focal dysplasia of the cerebral cortex in epilepsy显示文摘 | Taylor D C Falconer M A Bruton C J | 1971 | J Neurol Neurosurg Psychiatry1971，34，4： | 1 |
| 17 | Concentration and enantiomeric ratios of organochlorine pesticides in soils from the U S cornbelt显示文摘 | Leone A D Falconer R L | 1998 | Environ Sci Tech Nol1998，，32： | 1 |
| 18 | Superovulation and intrauterine insemination in cases of treated mild pelvic disease显示文摘 | Singh M Goldberg J Falcone T | 2001 | J Assist Reprod Genet2001，18，1： | 1 |
| 19 | Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro显示文摘 | ESFANDIARI N FALCONE T GOLDBERG J M | 2005 | Reprod Biomed Online2005，11，5： | 1 |
| 20 | Application of complementary sprit-ring resonators to the design of compact narrow band-pass structures in microstrip technology显示文摘 | J Bonache F Martfn F Falcone J D Baena | 2005 | Microwave and Optical Technology Letters2005，16，5： | 1 |
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