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| 1 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 2 | Neoadjuvant therapy for gastroesophageal adenocarcinoma显示文摘Gastric and esophageal adenocarcinomas are one of the main causes of cancer-related death worldwide. While the incidence of gastric adenocarcinoma is decreasing, the incidence of gastroesophageal junction adenocarcinoma is rising rapidly in Western countries. Considering that surgical resection is currently the major curative treatment, and that the 5-year survival rate highly depends on the p TNM stage at diagnosis, gastroesophageal adenocarcinoma management is very challenging for oncologists. Several treatment strategies are being evaluated, and among them systemic chemotherapy, to decrease recurrences and improve overall survival. The MAGIC and FNCLCCFFCD trials showed a survival benefit of perioperative chemotherapy in patients with operable gastric and lower esophageal cancer, and these results had an impact on the European clinical practice. New strategies, including induction chemotherapy followed by preoperative chemoradiotherapy, targeted therapies in combination with perioperative chemotherapy and the new cytotoxic regimens, are currently assessed to improve current standards and help developing patienttailored therapeutic interventions. | Emmanuelle Samalin Marc Ychou | 2016 | World Journal of Clinical Oncology2016，7，3： | 4 |
| 3 | Towards a pan-European consensus on the treatment of patients with colorectal liver metastases显示文摘 | Eric Van Cutsem Bernard Nordlinger Rene Adam Claus-Henning K?hne Carmelo Pozzo Graeme Poston Marc Ychou Philippe Rougier | 2006 | European Journal of Cancer2006，，14： | 2 |
| 4 | Adjuvant chemotherapy with 5-fluorouracil and cisplatin compared with surgery alone for gastric cancer:7-year results of the FFCD randomized phase Ⅲ trial (8801)显示文摘 | Bouche O Ychou M Burtin P | 2005 | Ann Oncol2005，16，9： | 1 |
| 5 | External beam radiation therapy and interstitial brachytherapy in the treatment of anal canal carcinomas: a series of 70 patients显示文摘 | Dubois JB Azria D Ychou M | 2003 | Bull Cancer2003，90，12： | 1 |
| 6 | Clinical practice guidelines:2004 Standards,Options and Recommendations for the management of patient with adenoearcinoma of the stomach radiotherapy显示文摘 | Ychou M Gory-Delabaere G Blanc P | 2004 | Cancer Radiother2004，8，5： | 1 |
| 7 | Pase Ⅲ preliminary results of preoperative fluorouracil(F) and cisplatin(P) versus surgery alone in adenocarcinoma of stomach and lower esophagus(ASLE) :FNLCC 94012- FFCD 9703 trial显示文摘 | Ychou M Pignon JP Lasser P | 2006 | J Clin Oncol2006，24，： | 1 |
| 8 | Plasma and salivary pharmacokinetics of 5-fluorouracil (5-FU) in patients with metastatic colorectal cancer receiving 5-FU bolus plus continuous infusion with high-dose folinic acid显示文摘 | Joulia JM Pinguet F Ychou M | 1999 | Eur J Cancer1999，35，2： | 1 |
| 9 | Phase-I/II radio-immunotherapy study with iodine-131-labeled anti-CEA monoclonal antibody F6 F(ab')2 in patients with non-resectable liver metastases from colorectal cancer 显示文摘 | Ychou M Pelegrin A Faurous P | 1998 | Int J Cancer1998，75，4： | 1 |
| 10 | An open phase I study assess- ing the feasibility of the trple combination:oxaliplatin plus irino- tecan plus leucovorin/5-fluorouracil every 2 weeks in patients with advanced sold tumors显示文摘 | Ychou M Conroy T Seitz JF | 2003 | Ann Oncol2003，14，： | 1 |
| 11 | Neoadjuvant treatment in upper gastrointestinal adenocarcinomas:new paradigms from old concepts?显示文摘 | Ychou M | 2007 | Curr Opin Oncol2007，19，4： | 1 |
| 12 | Phase Ⅲ Prelimminary Results of Preoperative Fluorouracil (F) and Cisplatin (P) Versus Surgery Alone in Adenocarcinoma of Stumach and Lower Esophagus (ASLE):FNLCC 94012-FFCD 9703 Trial显示文摘 | Ychou M Pignon JP Lasser P | 2006 | J Clin Oncol2006，24，18： | 1 |
| 13 | Individual5-FU dose adaptation in metastatic colorectalcancer: results of a phase II study using abimonthly pharmacokinetically intensified LV5FU2regimen显示文摘 | YCHOU M DUFFOURJ KRAMAR A etai | 2003 | Cancer Chemother Pharmacol2003，52，4： | 1 |
| 14 | FOLFIRINOXversus gemcitabine for metastatic pancreatic cancer显示文摘 | CONROY T DESSEIGNE F YCHOU M | 2011 | N Engl JMed2011，364，19： | 1 |
| 15 | Gemcitabine and pancreatic cancer显示文摘 | Prost P Ychou M Azria D | 2002 | Bull Cancer2002，，89： | 1 |
| 16 | Randomized comparison of prophylactic antidiarrheal treatment versus no prophylactic antidiarrheal treatment in patients receiving CPT-11 (irinotecan) for advanced 5-FU-resistant colorectal cancer:an open-label multicenter phase Ⅱ study显示文摘 | Ychou M Douillard JY Rougier P | 2000 | Am J Clin Oncol2000，23，2： | 1 |
| 17 | Irinotecan for the treatment of metastatic colorectal cancer显示文摘 | Assenat E Duffour J Ychou M | 2006 | Bull Cancer2006，93，5： | 1 |
| 18 | Comparison of serum CYFRA21-1 and SCC in the diagnosis of squamous cell esophageal carcinoma显示文摘 | Ychou M Khemissa-Akouz F Kramar A | 2001 | Bull Cancer2001，88，： | 1 |
| 19 | Adjuvant chemother apy with 5-fluorouracil and cisplatin compared with sur- gery alone for gastric cancer: 7-year results of the FFCD randomized phase III trial(8 801) 显示文摘 | Bouche O Ychou M Burtin P | 2005 | Ann Oncol2005，16，9： | 1 |
| 20 | Hepatic arterial oxaliplatin infusion plus intravenous chemotherapy in colorectal Cancer with inoperable hepatic metastases: a trial of the gastrointestinal group of the Federation Nationale des Centres de Lutte Contre le Cancer显示文摘 | Ducreux M Ychou M Laplanche A | 2005 | J Clin Oncol2005，23，： | 1 |
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