|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification and characterization of the minimal androgen-regulated kidney-specific kidney androgen-regulated protein gene promoter显示文摘肾调整雄激素的蛋白质(Kap ) 基因是由雄激素在老鼠肾特定、调整的织物近似小管房间(PTC ) 。在现在的学习,我们试图识别最小的 PTC 特定的调整雄激素的 Kap 倡导者并且分析它的雄激素反应元素(AREs ) 。Kap1542 倡导者 / 酶构造的一个删除系列是 assayed 在里面鼠肾(好) PTC 当面或 15 nM dihydrotestosterone (DHT ) 的缺席。Kap1542 和 Kap637 举办了低活动和没有雄激素正式就职;Kap224 举办了比 Kap1542 的高是到 5 褶层的 4- 的一项基础活动,但是被 DHT 仅仅稍微导致。Kap147 举办了比 Kap1542 的高是到 3 褶层的 2- 并且被 DHT 4- 导致到 6 褶层的一项基础活动。Kap77 废除了基础倡导者活动,但是被 DHT 仍然导致。结果证明在 vitro, Kap147 是一个最小的调整雄激素的倡导者。在不同房间的短暂 transfection 证明 Kap147 明确地在 PTC 开始了记者基因表示。顺序分析揭示了在位置 −124 和 Kap147 的 −39 定位的二潜在的 AREs。Mutational 试金证明仅仅在 −124 的 ARE 在好房间涉及雄激素反应。Electrophoretic 活动性移动试金也证实 −124 雄激素受体明确地一定。在结论,我们定义可以是为肾的学习的一个好模型的最小的 Kap147 倡导者在 vivo 导致一只雄激素特定的应答的海角的 PTC 特定的表示和分子的机制。 | Liqiang Fan Dianne O Hardy James F Catteral Jian Zhao Suxia Li | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 4 |
| 2 | Extracting typical occupancy schedules from social media (TOSSM) and its integration with building energy modeling显示文摘Building occupancy,one of the most important consequences of occupant behaviors,is a driving influencer for building energy consumption and has been receiving increasing attention in the building energy modeling community.With the vast development of information technologies in the era of the internet-of-things,occupant sensing and data acquisition are not limited to a single node or traditional approaches.The prevalence of social networks provides a myriad of publically available social media data that might contain occupancy information in the space for a given time.In this paper,we explore two approaches to extract the typical occupancy schedules for the input to the building energy simulation based on the data from social networks.The first approach uses text classification algorithms to identify whether people are present in the space where they are posting on social media.On top of that,the typical building occupancy schedules are extracted with assumed people counting rules.The second approach utilizes the processed Global Positioning System(GPS)tracking data provided by social networking service companies such as Facebook and Google Maps.Web scraping techniques are used to obtain and post-process the raw data to extract the typical building occupancy schedules.The results show that the extracted building occupancy schedules from different data sources(Twitter,Facebook,and Google Maps)share a similar trend but are slightly distinct from each other and hence may require further validation and corrections.To further demonstrate the application of the extracted Typical Occupancy Schedules from Social Media(TOSSM),data-driven models for predicting hourly energy usage prediction of a university museum are developed with the integration of TOSSM.The results indicate that the incorporation of TOSSM could improve the hourly energy usage prediction accuracy to a small extent regarding the four adopted evaluation metrics for this museum building. | Xing Lu Fan Feng Zhihong Pang Tao Yang Zheng O’Neill | 2021 | Building Simulation2021，14，1： | 3 |
| 3 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 4 | A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q 显示文摘 | Pang CP Fan BJ Canlas O | 2006 | Mol Vis2006，12，： | 1 |
| 5 | Public Governance and Corporate Finance: Evidence from Corruption Cases显示文摘 | FAN J P RUI O M ZHAO M | 2008 | Journal of Comparative Economics2008，36，3： | 1 |
| 6 | Transient variations in the serum concentrations of cell adhesion molecules following retrop- eritoneal laparoscopic and open radical nephrectomy for lo- caliz-ed renal-cell carcinoma显示文摘 | Yang L Fan T Wei O | 2012 | J Endourol2012，26，10： | 1 |
| 7 | A biomass-supported Na2CO3 sorbent for flue gas desulfurization显示文摘 | Shang H S Ti O Y Fan Y | | 0，，： | 1 |
| 8 | Transgene and mitochondrial DNA are indicators of efficient composting of transgenic pig carcasses显示文摘 | Dave Murray Roy G. Meidinger Serguei P. Golovan John P. Phillips Ivan P. O’Halloran Ming Z. Fan Roger R. Hacker Cecil W. Forsberg | 2006 | Bioresource Technology2006，，9： | 1 |
| 9 | Higher white blood cell counts are associated with an increased, risk for metabolic syndrome and more severe psychopathology in non- diabetic patients with schizophrenia 显示文摘 | Fan X Liu EY Freudenreich O | 2010 | Schizophr Res2010，118，13： | 1 |
| 10 | Mucosal cytokine imbalance in irritable bowel syndrome显示文摘 | Macsharry J O'Mahony L Fanning A | 2008 | ScandJ Gastroen- terol2008，43，12： | 1 |
| 11 | A snapshot of the status of problem-based learning(PBL)in Chinese medical schools显示文摘 | Fan A P Kosik R O Tsai T C | 2014 | Medical Teacher2014，36，7： | 1 |
| 12 | Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius显示文摘 | O HARA A M O REGAN P FANNING A | 2006 | Immunology2006，118，2： | 1 |
| 13 | Tumor microvessel density as a predictor recurrence after resection of hepatocellular carcinoma: a prospective study显示文摘 | Poon R T Ng I O Lau C Yu W C Yang Z F Fan S T | 2002 | J Clin Oncol2002，20，： | 1 |
| 14 | Changing patterns of strabismus: a decade of experience in Hong Kong显示文摘 | C B O Yu f HongkongD S P Fan V W Y Wong | 2002 | Br J Ophthalmol2002，86，： | 1 |
| 15 | Pharmacologic studies on radix puerariae: effect of puerarin on regional yocardial blood flow and cardiac hemodynamics in dogs with acute myocardial isochemia显示文摘 | Fan L L O'Keefe D D Powell W W J | 1985 | Chin Med J1985，98，： | 1 |
| 16 | Detection of antibody to LAV/ HTLV-Ⅲ in sera from hemophiliacs in China显示文摘 | Zeng Y Fan J Zhang O | 1986 | AIDS Res1986，2，1： | 1 |
| 17 | Better Survival in Female Patients With Hepatocellular Carcinoma: Oral Contraceptive Pills Related?显示文摘 | Chi Ming Lam Jamy L Yong Annie O Chan Kelvin K Ng Ronnie T Poon Chi Leung Liu Chung Mau Lo Sheung Tat Fan | 2005 | Journal of Clinical Gastroenterology2005，，6： | 1 |
| 18 | Amphiregulin induces human ovarian cancer cell invasion by down-regulating E-cadberin expression显示文摘 | So WK Fan O~ Lau MT | 2014 | FEBS Lett2014，588，21： | 1 |
| 19 | Tin whisker growth: Substrate effect understanding CTE mismatch and IMC formation显示文摘 | ZHANG Y FAN C XU C KHASELEY O ABYS J | 2004 | CircuiTree2004，17，6： | 1 |
| 20 | Ultimate Response of RC Beams Strengthened with CFRP Plates显示文摘 | FANNING P J KELLY O | 2001 | Journal of Composites for Construction2001，5，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员