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| 1 | LATERAL ORGAN BOUNDARIES DOMAIN transcription factors direct callus formation in Arabidopsis regeneration显示文摘在文化条件下面的植物纸巾或机关的显著新生能力有 underlain 为十年的一个广泛的惯例。在在 vitro 新生的植物的起始的步经常包含一个 pluripotent 房间团的正式就职称为的胼胝,它被植物激素植物生长素驾驶并且经由一条根发展小径发生。然而,管理胼胝形成的关键分子仍然保持未知。这里,我们证明 Arabidopsis 侧面的机关边界域(LBD )/ASYMMETRIC 象 LEAVES2 一样(ASL ) 抄写因素涉及胼胝形成节目的控制。植物生长素反应因素(ARF ) 下游的四 LBD 基因, LBD16, LBD17, LBD18 和 LBD29,被导致胼胝的媒介(计算机输入缩微胶卷) 很快并且戏剧性地在多重机关导致。每在 Arabidopsis 的四 LBD 基因的宫外的表示是足够的没有外长的植物激素,触发自发的胼胝形成,而 LBD 功能的抑制禁止计算机输入缩微胶卷导致的胼胝形成。而且, LBD 触发的胼胝类似于由宫外地激活的根分裂组织基因和有效新生能力的特征由计算机输入缩微胶卷导致了那。这些调查结果在胼胝正式就职进程把 LBD 抄写因素定义为关键管理者,从而建立在发信号的植物生长素和植物新生程序之间的一个分子的连接。 | Mingzhu Fan Chongyi Xu Ke Xu Yuxin Hu | 2012 | Cell Research2012，22，7： | 42 |
| 2 | Preliminary research on Megalake Jilantai-Hetao in the arid areas of China during the Late Quaternary显示文摘我们识别了 geomorphological,在通过地调查并且通过地区性的遥感的分析的当前的 Jilantai 盐湖附近的高湖层次的沉积、生物的证据想象。在约 1060, 1050, 1044 和 1035 m a.s.l 的举起有四组海岸线,是在当前的盐湖上面的 37, 27, 21 和 12 m 分别地出现。沙和石子的沿岸的存款在在 1070 和 1080 m a.s.l 之间的举起被发现,比水流高的 47 ~ 57 m 腌湖表面,尽管 palaeoshoreline 地形仅仅在几个地点被保存。在 Herimuxini,在 Ulan Buh 荒芜的、典型湖的沉积和沙石子的北边缘上,沿岸的存款也发生在 1080 m a.s.l 并且在下面的举起。典型吐痰扩大的 A 11-km-long 从逐渐地在它的大拐弯上沿着黄河的南部的银行在一些沙石子石场从 1050 ~ 1035 m a.s.l 在举起减少的这条海岸线东方海岸线特征例如在水文学计量器车站和 Shilazhao 镇附近定位的那些,被识别。沿岸的存款 overlying 冲积的洪水的层在 Hangjin 在 Balagong 附近发生在沙石场县。也有沙滩岩石和沿岸的存款,沿着 Langshan-Yinshan 山的南部的山麓在几个地点在 cut-and-built 平台上保存。另外,揭示水下的三角洲沉积的侧面在 Wuhai 附近被识别,在黄河进入盆的地方。典型的湖沉积也在 Hetao 平原的东方结束在 Togtoh 站台存在。水的软体动物壳在沿岸的存款是普通的,包括 Corbicula 的几种,根值 lagotis, R。xauricularia 和 Gyraulus convexiusculus。Ostracode 壳能也在更好的沉积被识别。典型垂直 prograding 序列在湖的沉积很好被保存的露头是明显的。滚动波浪的卵石和沙滩岩石很通常在更高的举起在堤在侧面的顶上被保存。所有这些证据建议曾经有一个巨大的palaeo湖,用到达我们指的 ∼1080 m a.s.l 的最高的湖水平盖住 Jilantai 区域和 Hetao 平原的大多数部分巨大的 paleolake ,比现代的湖贝加尔湖大,作为“ Megalake Jilantai-Hetao ”. OSL 标明日期结果显示大湖以前形成了 ∼60 —50 ka,和在在 1060 和 1035 m a.s.l 之间的举起的四条海岸线多半从 ∼60 ∼50 ka 代表湖水平变化到早 Holocene。Megalake Jilantai-Hetao 的发现将多半影响黄河的发展的理解在期间晚第四级, Ulan Buh 和 Kubq 的进化抛弃,在这个区域的 neotectonism,并且可能地区性的气候的变化。 | CHEN FaHu FAN YuXin CHUN Xi D.B. MADSEN C.G. OVIATT ZHAO Hui YANG LiPing SUN Yang | 2008 | Chinese Science Bulletin2008，53，11： | 23 |
| 3 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 4 | Sedimentary documents and Optically Stimulated Luminescence (OSL) dating for formation of the present landform of the northern Ulan Buh Desert,northern China显示文摘GPR reflecting sections and core profiles revealed that sand dunes of the northern Ulan Buh Desert are overlying shallow lacustrine or palustrine sediments. Optical dating results of sediments from three core profiles indicate that the area of the northern Ulan Buh Desert was still covered by the shallow lake or marsh during 8.4-6.4 ka, and eolian sand started to accumulate since around 2 ka. Such a result supports the idea that the present desert landform of the northern Ulan Buh Desert started to form since 2 ka, which was likely a response to the desertification caused by ruin of the Han Dynasty and the large-scale abandonment of farming of the Han nationality. Our research results are consistent with the previous archaeological studies, and support the idea that the Ulan Buh Desert is composed of two parts with different histories, i.e., the old southern Ulan Buh Desert and the young northern Ulan Buh Desert. | Fan YuXin Chen FaHu Fan TianLai Zhao Hui Yang LiPing | 2010 | Science China Earth Sciences2010，53，11： | 15 |
| 5 | Sedimentary and OSL dating evidence for the development of the present Hobq desert landscape, northern China显示文摘The sedimentary sequence and landscape of the Hobq desert was observed through twelve profiles along five N-S sections extending through the entire desert.Aeolian sands were found to overlie the alluvial,diluvial,and lacustrine sediments in this desert.Optically stimulated luminescence(OSL)dating results were obtained from post-IR OSL signals of quartz fractions of sand samples at the bottom of sand dunes and hills by using the Double-SAR protocol.The OSL ages reveal that the latest sand accumulation began around 19 ka in the northwestern part and 9 ka in the eastern part of the Hobq Desert.Around 7 ka,the sand accumulation was strengthened and extended southward and northward 2 ka to develop the present desert landscape.Our study suggests that the aeolian sand accumulation around 19,9 and 7 ka resulted from the weakening of the Asian summer monsoon over this region.However,the rapid development of the present Hobq desert landscape since 2 ka was likely triggered by human activities in this desert. | FAN YuXin CHEN XiaoLong FAN TianLai JIN Ming LIU JianBao CHEN FaHu | 2013 | Science China Earth Sciences2013，56，12： | 11 |
| 6 | Promoting ring-opening efficiency for suppressing toxic intermediates during photocatalytic toluene degradation via surface oxygen vacancies显示文摘Aromatic ring-opening process is well recognized as the rate-determining step for catalytic toluene degradation. In photocatalytic toluene degradation, the toxic intermediates w让h harmful effects may be generated. To clarify the precise reaction mechanism and control the toxic intermediates generation, a closely combined in situ DRIFTS and DFT calculation is utilized to address these important issues. We construct the BiOCl w让h oxygen vacancies (OVs) and reveal the structure of OVs. The defect level caused by oxygen vacancies could promote the light adsorption and charge separation, which further boosts the activation of ring-opening species and enhances the generation process of free radicals. The reaction energy barriers of four possible ring-opening processes on defective BiOCl (OVBOC) are all declined in comparison with perfect BiOCl (BOC). The existence of oxygen vacancies could smooth the ratedetermining step so the ring-opening efficiency of photocatalytic toluene degradation is highly increased. Most importantly, the methyl species would be further oxidized and tend to open the benzene-ring at benzoic acid on BOC while the ring would be broken at the benzyl alcohol on OVBOC. These results indicate that the toluene degradation pathway is shortened via the surface OVs, which enables the production of radicals with high oxidation capability for the accelerated chain scission of the ring-opening intermediates. Finally, the efficiency of the key ring-opening process could be enormously improved and toxic intermediates are effectively restrained. The present work could provide new insights into the design of high-performance photocatalysts for efficient and safe degradation of VOCs in air. | Xing'an Dong Wen Cui Hong Wang Jieyuan Li Yanjuan Sun Haiqiang Wang Yuxin Zhang Hongwei Huang Fan Dong | 2019 | Science Bulletin2019，64，10： | 9 |
| 7 | Highly enhanced visible-light photocatalytic NOx purification and conversion pathway on self-structurally modified g-C-3N4 nanosheets显示文摘The unmodified graphitic carbon nitride(g-C_3N_4) suffers from low photocatalytic activity because of the unfavourable structure.In the present work,we reported a simple self-structural modification strategy to optimize the microstructure of g-C_3N_4 and obtained graphene-like g-C_3N_4 nanosheets with porous structure.In contrast to traditional thermal pyrolysis preparation of g-C_3N_4,the present thermal condensation was improved via pyrolysis of thiourea in an alumina crucible without a cover,followed by secondary heat treatment.The popcorn-like formation and layer-by-layer thermal exfoliation of graphene-like porous g-C_3N_4 was proposed to explain the formation mechanism.The photocatalytic removal performance of both NO and NO_2 with the graphene-like porous g-C_3N_4 for was significantly enhanced by selfstructural modification.Trapping experiments and in-situ diffuse reflectance infrared fourier transform spectroscopy(DRIFTS) measurement were conducted to detect the active species during photocatalysis and the conversion pathway of g-C_3N_4 photocatalysis for NO_x purification was revealed.The photocatalytic activity of graphene-like porous g-C_3N_4 was highly enhanced due to the improved charge separation and increased oxidation capacity of the ·O_2^- radicals and holes.This work could not only provide a novel self-structural modification for design of highly efficient photocatalysts,but also offer new insights into the mechanistic understanding of g-C_3N_4 photocatalysis. | Yuhan Li Yanjuan Sun Wingkei Ho Yuxin Zhang Hongwei Huang Qiang Cai Fan Dong | 2018 | Science Bulletin2018，63，10： | 7 |
| 8 | Virus-induced gene silencing(VIGS)in Chinese narcissus and its use in functional analysis of NtMYB3显示文摘Virus-induced gene silencing(VIGS)is a natural defense mechanism of plants,which can cause sequence-specific degradation of viral RNA and is often used for studying the functional genome.At present,the VIGS system mediated by Tobacco rattle virus(TRV)has been successfully established in many plant species.However,the VIGS system in Chinese narcissus had not been reported yet.In this paper,the first use of the TRV-VIGS system in Chinese narcissus is described in detail.By injecting pTRV2-GFP into narcissus leaves,we confirmed that TRV could infect narcissus and move in narcissus plants.After the inoculation of pTRV2-Nt PDS by two methods,phenomena such as photo-bleaching appeared in narcissus leaves and qRT-PCR results proved that PDS gene of narcissus was successfully silenced.Besides,pTRV2-NtMYB3 was inoculated into basal plates of narcissus to study the function of NtMYB3;the results showed that NtMYB3 is an inhibitor of flavonoids biosynthesis,which can increase the content of proanthocyanidins in basal plates of narcissus by repressing the expression level of NtFLS.These results indicate that the TRV-VIGS system has been successfully established in Chinese narcissus and successfully applied to the functional study of NtMYB3. | Ping Zhou Jiayu Peng Minjie Zeng Lixuan Wu Yuxin Fan Lihui Zeng | 2021 | Horticultural Plant Journal2021，7，6： | 4 |
| 9 | Anion intercalated layered-double-hydroxide structure for efficient photocatalytic NO remove显示文摘Due to the easily controllable interlayer anions, metal cation composition proportion and thickness, which is beneficial to modify surface chemical state and tune bandgap, layered double hydroxides(LDHs) have great promising potential for photocatalytic applications. In this study,we have successfully synthesized the ZnAl–LDH intercalated the single anion between ZnAl cationic interlayer without anionic impurities by using a facile calcining and reconstructing routes. The electron structure and surface chemical state of the prepared products have been investigated by combining the DFT calculation and experimental characterization methods. UV–vis DRS was used to certify the light absorption of the prepared products, and we performed the DFT calculation to demonstrate the density of state and activation of reactant. These results suggested that the ZnAl–LDH–CO3 possessed the more proper band structure and superior ability to activate NO and O2 for accelerating the photocatalytic NO oxidation activity. Moreover, the in situ DRIFTS with dynamically monitoring intermediates and products over the ZnAl–LDH–CO3 was adopted to declare the photocatalytic NO oxidized process during the photocatalytic reaction process. This work illustrated the influence of different interlayer anions to the electron structure and surface chemical state of ZnAl–LDH structure through the experimental verification combined DFT calculation and the photocatalytic NO oxidized process via in situ DRIFTS analyzing, which would provide a novel way to design and fabricate the efficient photocatalysis, and understand the reaction process. | Wangchen Huo Tong Cao Xiaoying Liu Weina Xu Biqin Dong Yuxin Zhang Fan Dong | 2019 | Green Energy & Environment2019，4，3： | 4 |
| 10 | Formation of present desert landscape surrounding Jilantai Salt Lake in northern China based on OSL dating显示文摘Jilantai 盐湖(JSL ) ,重要性的一个湖由于它在中国的盐生产自从早 Qing 王朝,被沙沙丘包围。这些沙沙丘的发展的探索将对识别位于荒芜的风景下面的力量并且为识别一个答案保护盐资源有用。通过地调查,我们在更高的湖岸上在更低的高度或沿岸的沉积在湖床上发现沙沙丘 overlying 湖的任何一个和沼泽存款。标明日期的光学地刺激的光(OSL ) 结果显示沙开始象早 Holocene (约 11 ka ) 一样早在 JSL 附近积累,当沙沙丘的快速的发展发生了在以内时最近 0.1 ka。由有在邻近的区域的气候的文件和人的活动的比较,在象早 Holocene 一样早的 JSL 附近的沙累积的开始被认为是在 Jilantai 区域的低有效潮湿的结果。然而,在包围 JSL 的广阔区域的沙沙丘的快速的发展被发生了在以内的加强的人的活动多半开始最近在温暖、干燥的气候的条件下面的 0.1 ka。 | Yuxin FAN Xiaolong CHEN Wenhao LIU Fu ZHANG Fan ZHANG | 2015 | Frontiers of Earth Science2015，9，3： | 4 |
| 11 | Dose-dense paclitaxel plus carboplatin vs.epirubicin and cyclophosphamide with paclitaxel as adjuvant chemotherapy for high-risk triple-negative breast cancer显示文摘Objective:The objective of this open-label,randomized study was to compare dose-dense paclitaxel plus carboplatin(PCdd)with dose-dense epirubicin and cyclophosphamide followed by paclitaxel(ECdd-P)as an adjuvant chemotherapy for early triple-negative breast cancer(TNBC).Methods:We included Chinese patients with high recurrence risk TNBC who underwent primary breast cancer surgery.They were randomly assigned to receive PCdd[paclitaxel 150 mg/m2 on d 1 and carboplatin,the area under the curve,(AUC)=3 on d 2]or ECdd-P(epirubicin 80 mg/m2 divided in 2 d and cyclophosphamide 600 mg/m2 on d 1 for 4 cycles followed by paclitaxel 175 mg/m2 on d 1 for 4 cycles)every 2 weeks with granulocyte colony-stimulating factor(G-CSF)support.The primary endpoint was 3-year disease-free survival(DFS);the secondary endpoints were overall survival(OS)and safety.Results:The intent-to-treat population included 143 patients(70 in the PCdd arm and 73 in the ECdd-P arm).Compared with the ECdd-P arm,the PCdd arm had significantly higher 3-year DFS[93.9%vs.79.1%;hazard ratio(HR)=0.310;95%confidence interval(95%CI),0.137-0.704;log-rank,P=0.005]and OS(98.5%vs.92.9%;HR=0.142;95%CI,0.060-0.825;log-rank,P=0.028).Worse neutropenia(grade 3/4)was found in the ECdd-P than the PCdd arm(47.9%V5.21.4%,P=0.001).Conclusions:PCdd was superior to ECdd-P as an adjuvant chemotherapy for early TNBC with respect to improving the 3-year DFS and OS.PCdd also yielded lower hematological toxicity.Thus,PCdd might be a preferred regimen for early TNBC patients with a high recurrence risk. | Qing Li Jiani Wang Yuxin Mu Tongtong Zhang Ying Han Jiayu Wang Qiao Li Yang Luo Fei Ma Ying Fan Pin Zhang Binghe Xulj | 2020 | Chinese Journal of Cancer Research2020，32，4： | 4 |
| 12 | Inhibition of the toxic byproduct during photocatalytic NO oxidation via La doping in ZnO显示文摘It is of a great challenge to develop semiconductor photocatalysts with potential possibilities to simultaneously enhance photocatalytic efficiency and inhibit generation of toxic intermediates.In this study,we developed a facile method to induce the La doping and cationic vacancie(V(Zn))on ZnO for the highly efficient complete NO oxidation.The photocatalytic NO removal efficiency increases from 36.2%to 53,6%.Most importantly,a significant suppressed NO2 production also has been realized.According to the DFT calculations,ESR spectra and in situ FTIR spectra,the introduction of La^3+induce the redistribution of charge carriers in La-ZnO,which promote the production of·O2^- and lead to the formation of V(Zn)for the formation of·OH,contributing to the complete oxidation of NO to nitrate.Besides,the conversion pathway of photocatalytic NO oxidation has been elaborated,This work paves a new way to simultaneously realize the photocatalytic pollutants removal and the inhibition of toxic intermediates generation for efficient and safe air purification. | Chaowei Yuan Wen Cui Yanjuan Sun Jiadong Wang Ruimin Chen Jin Zhang Yuxin Zhang Fan Dong | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 13 | Developing a microfluidic-based system to quantify cell capture efficiency显示文摘Micro-fabrication technology has substantial potential for identifying molecular markers expressed on the surfaces of tissue cells and viruses. It has been found in several conceptual prototypes that cells with such markers are able to be captured by their antibodies immobilized on microchannel substrates and unbound cells are flushed out by a driven flow. The feasibility and reliability of such a microflu- idic-based assay, however, remains to be further tested. In the current work, we developed a microflu- idic-based system consisting of a microfluidic chip, an image grabbing unit, data acquisition and analysis software, as well as a supporting base. Specific binding of CD59-expressed or BSA-coupled human red blood cells (RBCs) to anti-CD59 or anti-BSA antibody-immobilized chip surfaces was quan- tified by capture efficiency and by the fraction of bound cells. Impacts of respective flow rate, cell concentration, antibody concentration and site density were tested systematically. The measured data indicated that the assay was robust. The robustness was further confirmed by capture efficiencies measured from an independent ELISA-based cell binding assay. These results demonstrated that the system developed provided a new platform to effectively quantify cellular surface markers effectively, which promoted the potential applications in both biological studies and clinical diagnoses. | YANG Fan, GAO YuXin, ZHANG Yan, CHEN Juan & LONG Mian National Microgravity Laboratory and Center for Biomechanics and Bioengineering, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China | 2009 | Science China(Life Sciences)2009，52，2： | 3 |
| 14 | Hypertrophic cardiomyopathy: Can the noninvasive diagnostic testing identify high risk patients?显示文摘Hypertrophic cardiomyopathy(HCM) is the most common cause of sudden cardiac death(SCD) in the young, particularly among athletes. Identifying high risk individuals is very important for SCD prevention. The purpose of this review is to stress that noninvasive diagnostic testing is important for risk assessment. Extreme left ventricular hypertrophy and documented ventricular tachycardia and fibrillation increase the risk of SCD. Fragmented QRS and T wave inversion in multiple leads are more common in high risk patients. Cardiac magnetic resonance imaging provides complete visualization of the left ventricular chamber, allowing precise localization of the distribution of hypertrophy and measurement of wall thickness and cardiac mass. Moreover, with late gadolinium enhancement, patchy myocardial fibrosis within the area of hypertrophy can be detected, which is also helpful in risk stratification. Genetic testing is encouraged in all cases, especially in those with a family history of HCM and SCD. | Li Zhang Obinna Mmagu Liwen Liu Dayuan Li Yuxin Fan Adrian Baranchuk Peter R Kowey | 2014 | World Journal of Cardiology2014，6，8： | 3 |
| 15 | Photoelectrocatalytic carbon dioxide reduction: Fundamental, advances and challenges显示文摘With the rising global population,increasing energy demand and rapid climate change,great concems have been raised for environment and energy security in future.Solar-driven CO_(2) reduction provides a promising way to deal with energy crists and global warming,which has been widely concemed.Photoelectrocatalysis technology can effectively utilize solar energy and avoid to use high-temperature and high-voltage reduction environment by integrating the vantages of both photocatalysis and electrocatalysis,which exhibits a broad application prospect of CO_(2) reduction with a high efficiency and ecellent selectivity.In this review,basic pr inciples of CO_(2) reduction by photocatalysis,electrocatalysis and photoeletrocatalysis are briely reviewed,also comparing the technical character istics of the above technologies.Diferent photoelectrocatalyde systems for CO_(2) reduction are described and compared.The several key influencing factors of photoeletrocatalytic performance of CO_(2) reduction are discussed,including inter action between reaction molecules and catalysts,reaction conditions and influence of photoelectrode.Then,the advances on reaction mechanisms and strategies of perfor mance enhancement by opd:mizing photoexcitation,charge separation efficiency and surface reaction were reviewed.Besides,the chal-lenges and prospects of photoelectrocatalyde CO_(2) reduction will be also discussed. | Peng Chen Yuxin Zhang Ying Zhou Fan Dong | 2021 | Nano Materials Science2021，3，4： | 3 |
| 16 | Effect of volatile oil from Blumea Balsamifera(L.) DC. leaves on wound healing in mice显示文摘OBJECTIVE: To assess the effectiveness of violateoil from Blumea Balsamifera(L.) DC. leaves(BB oil)on wound healing in mice.METHODS: Undiluted BB oil and its diluted solutions with olive oil to 1/5 and 1/10 to yield BB oil1/5and BB oil1/10 were applied to the wounded skin before wound healing conditions were assessed by healing rate, histopathology, and contents of collagen, hydroxyproline, and Neuropeptide Substance P(SP). All above results were compared with the efficacies of the control, pure olive oil, basic fibroblast growth factor(BFGF), and cream of Jing Wan Hong(JWH).RESULTS: BB oil1/5and BB oil1/10 improved wound contraction and closure. Histopathology study further confirmed a desirable histological organization of wound tissues. BB oil1/5and BB oil1/10 reduced the number of inflammatory cells, increased wound-healing rates, and significantly increased the hydroxyproline content. Both BB oil1/5and BB oil1/10 improved formation of collagen, and reduced the frequency of fibroblasts. Moreover, BB oil1/5and BB oil1/10 markedly promoted SP expression. However, undiluted BB oil may induce skin thickening and hardening, inhibite collagen synthesis and delay complete skin wound healing.CONCLUSION: The BB oil1/5and BB oil1/10 promoted capillary regeneration, blood circulation, collagen deposition, granular tissue formation, epithelial deposition, and wound contraction. The mechanism underlying the action might be related to induction of SP secretion, and the proliferation and differentiation of mesenchymal cells. | Yuxin Pang Dan Wang Xuan Hu Hui Wang Wanjin Fu Zuowang Fan Xiaolu Chen Fulai Yu | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
| 17 | Timely renal replacement therapy linked to better outcome in patients with sepsis-associated acute kidney injury显示文摘Background:Recent studies suggest that acute kidney injury(AKI)can be treated with renal replacement therapy(RRT).However,its benefits to patients with sepsis-associated AKI(SA-AKI),which is linked to high mortality and morbidity rates,remain under debate.The aim of this study was to compare the outcomes of different RRT strategies for patients with SA-AKI.Methods:This retrospective study evaluated patients who were admitted to the hospital with sepsis and devel-oped SA-AKI during hospitalization from 1st January 2014 to 31st January 2019.Mortality,renal recovery,and systemic organ function at 90 days following admission were compared between the RRT group(RG)and non-RRT group(NRG),as well as the early-RRT group(EG)and delayed-RRT group(DG).The groups were defined according to the time from admission to RRT initiation(criterion 1,EG1 and DG1)and Kidney Disease Improving Global Outcomes(KDIGO)classification(criterion 2,EG2 and DG2).Categorical and continuous variables were compared using the chi-squared test or Fisher’s exact test and Student’s t-test or Wilcoxon test.Kaplan-Meier curves were constructed to determine the unadjusted survival rates for the different subgroups.Results:A total of 116 patients were included in this study;of those,38 received RRT and 46 expired within 90 days.Among different strategies of RRT,there were no significant differences found in 90-day mortality(RG vs.NRG:��2=0.610,P=0.435;EG1 vs.DG1:��2=0.835,P=0.360;EG2 vs.DG2:��2=0.022,P=0.899)and renal recovery.However,the values of change in sequential organ failure assessment(ΔSOFA)max-min of patients in the EG and RG were significantly higher than those recorded in the NRG(ΔSOFA RG=7.0,ΔSOFA NRG=3.60,ΔSOFA EG1=9.00,ΔSOFA EG2=6.30;P<0.050).Also,the 90-day renal recovery in the EG was better than that noted in the DG with criterion 1(87.5%vs.38.5%,respectively,��2=10.425,P=0.032),suggesting that RRT(especially timely RRT)may be beneficial to the restoration of systemic organ function in patients with SA-AKI.Conclusion:RRT did not reduce the 90-day mortality among patients with SA-AKI.However,timely RRT may benefit the restoration of systemic organ function,thereby improving the quality of life of patients. | Yiwen Fan Liang Chen Shaowei Jiang Yingying Huang Yuxin Leng Chengjin Gao | 2022 | Journal of Intensive Medicine2022，2，3： | 2 |
| 18 | The pseudocapacitance mechanism of graphene/CoAl LDH and its derivatives:Are all the modifications beneficial?显示文摘Cobalt-Aluminum layered double hydroxide(CoAl LDH) is a hopeful electrode material due to the advantage of easy modifiability for preparing LDH-based derivatives.However,there is short of modification methods to prepare the Co-based derivatives from CoAl LDH and also short of an intuitive perspective to analyze the pseudocapacitance mechanism of CoAl LDH and its derivatives.Herein,Graphene/CoAl LDH and its derivatives including Graphene/CoS,Graphene/CoS-1,Graphene/CoOOH,Graphene/CoP were prepared by reasonably using alkali etching treatment,sulfofication and phosphorization.The specific capacitance of Graphene/CoAl LDH,Graphene/CoS,Graphene/CoS-1,Graphene/CoOOH,Graphene/CoP at1 A g^(-1) are 260.7,371.3,440.8,61.4 and 122.2 F g^(-1),especially.The pseudocapacitance mechanism of Graphene/CoAl LDH and its derivatives was analyzed.Due to the positive effect of sulfofication on the electrical conductivity of GO and cobalt sulfide,the Graphene/CoS and Graphene/CoS-1 exhibit the optimal electrochemical performance and superior rate capability.In addition,due to the repulsion effect between Graphene and OH-,the Graphene/CoAl LDH exhibits optimal cycling stability of 224.1% capacitance retention after 20000 cycles.Besides,the reason of terrible specific capacitance of Graphene/CoOOH is that the presence of H bond in interlayer of CoOOH inhibits the interaction between Co3+ and OHspecies.Hence,not all modifications will increase the specific capacitance of the electrode materials.Overall,this work provides us with a detailed analysis of the electrochemical mechanism and correlation of CoAl LDH and its derivatives from the perspective of crystal structure and composition. | Chuan Jing Xu Dong Liu Kailin Li Xiaoying Liu Biqin Dong Fan Dong Yuxin Zhang | 2021 | Journal of Energy Chemistry2021，30，1： | 2 |
| 19 | Forty-five terawatt vortex ultrashort laser pulses from a chirped-pulse amplification system显示文摘We report on a vortex laser chirped-pulse amplification(CPA)system that delivers pulses with a peak power of 45 TW.A focused intensity exceeding 1019 W/cm2 has been demonstrated for the first time by the vortex amplification scheme.Compared with other schemes of strong-field vortex generation with high energy flux but narrowband vortex-converting elements at the end of the laser,an important advantage of our scheme is that we can use a broadband but size-limited q-plate to realize broadband mode-converting in the front end of the CPA system,and achieve high-power amplification with a series of amplifiers.This method is low cost and can be easily implemented in an existing laser system.The results have verified the feasibility to obtain terawatt and even petawatt vortex laser amplification by a CPA system,which has important potential applications in strong-field laser physics,for example,generation of vortex particle beams with orbital angular momentum,fast ignition for inertial confinement fusion and simulation of the extreme astrophysical environment. | Zhenkuan Chen Shuiqin Zheng Xiaoming Lu Xinliang Wang Yi Cai Congying Wang Maijie Zheng Yuexia Ai Yuxin Leng Shixiang Xu Dianyuan Fan | 2022 | High Power Laser Science and Engineering2022，10，5： | 1 |
| 20 | Light-Induced Dynamic Stability of Oxygen Vacancies in BiSbO_(4) for Efficient Photocatalytic Formaldehyde Degradation显示文摘Defect engineering has been regarded as a versatile strategy to maneuver the photocatalytic activity.However,there are a few studies concerning how to maintain the stability of defects,which is important to ensure sustainable photocatalytic performance.Here,a novel strategy to modulate the structural properties of BiSbO_(4)using light-induced dynamic oxygen vacancies is reported by us for efficient and stable photocatalytic oxidation of formaldehyde.Interestingly,the continuous consumption and replenishment of vacancies(namely dynamic vacancies)ensure the dynamic stability of oxygen vacancies,thus guaranteeing the excellent photocatalytic stability.The oxygen vacancies could also accelerate the electron migration,inhibit the photogenerated electron/hole recombination,widen the light absorption spectra,and thus improve the photocatalytic formaldehyde removal performance.Combined with the results of in situ DRIFTS,the reaction mechanism for each step of formaldehyde oxidation is revealed.As supported by DFT calculation of Gibbs free energy,the introduction of oxygen vacancies into BiSbO_(4)can promote spontaneous process of formaldehyde oxidation.Our work highlights a promising approach for stabilizing the defects and proposes the photocatalytic reaction mechanism in combination with the thermodynamic functions. | Maoxi Ran Wen Cui Kanglu Li Lvcun Chen Yuxin Zhang Fan Dong Yanjuan Sun | 2022 | Energy & Environmental Materials2022，5，1： | 1 |
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