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| 1 | Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK显示文摘Accumulation of plasma advanced oxidation protein products(AOPPs) promotes progression of proteinuria and glomerulo-sclerosis.To investigate the molecular basis of AOPPs-induced proteinuria,normal Sprague-Dawley rats were treated with AOPPs-modified rat serum albumin.The expression of glomerular podocyte slit diaphragm(PSD)-associated proteins,nephrin and podocin,was significantly decreased coincident with the onset of albuminuria in rats treated with AOPPs.Chronic inhibi-tion of NADPH oxidase by apocynin prevented down-regulation of nephrin and podocin and decreased albuminuria in AOPPs-challenged rats.This suggested that accumulation of AOPPs promotes proteinuria,possibly via down-regulating the expression of PSD-associated proteins. | YANG Li,LIANG Min,ZHOU QiuGen,XIE Di,LOU AiJu,ZHANG Xun & HOU FanFan Key Laboratory for Organ Failure Research,Division of Nephrology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. | 2010 | Science China(Life Sciences)2010，53，1： | 14 |
| 2 | Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression显示文摘联系癌的成纤维细胞(CAF ) 在在乳癌便于肿瘤前进和转移起中央作用。Galectin-1 (Gal-1 ) , CAF 的一个标记,以前被报导与肿瘤的各种各样的类型的 tumorigenesis 和转移被联系。这研究的目的是在调停 CAF 的乳癌转移和它的内在的分子的机制调查 Gal-1 的角色。我们的结果显示出与配对的正常成纤维细胞,和显著地导致的 CAF 的调节媒介(厘米) 相比从 Gal-1 高级的表示的人的胸肿瘤纸巾孤立的那 CAF 人的 MDA-MB-231 乳癌房间的迁居和侵略。在 CAF 的 Gal-1 击倒戏剧性地禁止的 CAF-CM-induced 房间移植和侵略,可能由禁止矩阵 metalloprotein 的表达式 9 (MMP-9 ) 。我们的调查结果证明 Gal-1-regulated CAF 激活由 upregulating MMP-9 表示支持乳癌房间转移,它显示在 CAF 的 Gal-1 可能是为乳癌的一个潜在的新奇目标治疗。 | Xue Zhu Ke Wang Kai Zhang Fei Xu Yongxiang Yin Ling Zhu Fanfan Zhou | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 3 | Carbon dioxide adsorption of two-dimensional carbide MXenes显示文摘Two-dimensional carbide MXenes(Ti_3C_2T_x and V_2CT_x)were prepared by exfoliating MAX phases(Ti_3AlC_2 and V_2AlC)powders in the solution of sodium fluoride(NaF)and hydrochloric acid(HCl).The specific surface area(SSA)of as-prepared Ti_3C_2T_x was 21 m^2/g,and that of V_2CT_x was 9 m^2/g.After intercalation with dimethylsulfoxide,the SSA of Ti_3C_2T_x was increased to 66 m^2/g;that of V_2CT_x was increased to 19 m^2/g.Their adsorption properties on carbon dioxide(CO_2)were investigated under 0–4 MPa at room temperature(298 K).Intercalated Ti_3C_2T_x had the adsorption capacity of 5.79 mmol/g,which is close to the capacity of many common sorbents.The theoretical capacity of Ti_3C_2T_x with the SSA of 496 m^2/g was up to 44.2 mmol/g.Additionally,due to high pack density,MXenes had very high volume-uptake capacity.The capacity of intercalated Ti_3C_2T_(x )measured in this paper was 502 V·v^(–1).This value is already higher than volume capacity of most known sorbents.These results suggest that MXenes have some advantage features to be researched as novel CO_2 capture materials. | Bingxin WANG Aiguo ZHOU Fanfan LIU Jianliang CAO Libo WANG Qianku HU | 2018 | Journal of Advanced Ceramics2018，7，3： | 9 |
| 4 | New data regarding acritarch biostratigraphy from the Early-Middle Cambrian Kaili Formation in Chuandong,Guizhou Province,China显示文摘Previous studies had evaluated acritarchs from the Balang and Pingzhai sections of the Early-Middle Cambrian Kaili Formation in east Guizhou,China.The results of these studies suggest that the acritarchs in these sections have potential biostratigraphic significance.More recently,34 samples collected from 83 m lower part of the Lower-Middle Cambrian Kaili Formation in the Jianshan section of Chuandong,Guizhou Province were prepared for palynological analysis.Analysis of these samples revealed a distinct change in the acritarch assemblages at the bed,which was approximately 46 m above the bottom of the Kaili Formation.These findings suggest a boundary represented by an important alteration of the ecological environment.In addition,the position of the acritarch biostratigraphic change is somewhat higher than the boundary between Cambrian Series 2 and Series 3 based on trilobites found in the same section.This indicates that the distinct change in acritarch assemblages is similar to the change in trilobite assemblages that occurs around the boundary between Cambrian Series 2 and Series 3.Therefore,acritarch biostratigraphy can provide data that can be used to define the base of Cambrian Series 3 in this region,and possibly worldwide. | Leiming Yin Ruidong Yang Jin Peng Fanfan Kong | 2009 | Progress in Natural Science:Materials International2009，19，1： | 9 |
| 5 | Microfluidic generation of egg-derived protein microcarriers for 3D cell culture and drug delivery显示文摘Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this technique tend to focus on the fabrication of functional microparticles by using convenient methods with innovative but accessible materials.Inspired by the process of boiling eggs in everyday life,which causes the solidification of egg proteins,we present a new microfluidic‘‘cooking'approach for the generation of egg-derived microcarriers for cell culture and drug delivery.As the egg emulsion droplets are formed with exquisite precision during the microfluidic emulsification,the resultant egg microcarriers present highly monodisperse and uniform morphologies at the size range of hundred microns to one millimeter.Benefiting from the excellent biocompatibility of the egg protein components,the obtained microcarriers showed good performances of cell adherence and growth.In addition,after a freezing treatment,the egg microcarriers were shown to have interconnected porous structures throughout their whole sphere,could absorb and load different kinds of drugs or other active molecules,and work as microcarrier-based delivery systems.These features point to the potential value of the microfluidic egg microcarriers in biomedicine. | Yuxiao Liu Qian Huang Jie Wang Fanfan Fu Jianan Ren Yuanjin Zhao | 2017 | Science Bulletin2017，62，18： | 8 |
| 6 | The Intelligent Control System of Traffic Light Based on Fog Computing显示文摘The continuous increase of city motors with the improvement of society has introduced extraordinary demanding situations for the traffic situation of the town.Intelligent traffic has proposed a diversity of solutions to relieve urban traffic accidents and congestion and other troubles. It cannot regulate the cycle of traffic light in real time in keeping with the occurring traffic flux which additionally, may produce the traffic jam to result in the increase for the range of automobiles and the longer of passage time. In purpose to surmount the shortcomings of traditional traffic light control, this paper is presenting a form of intelligent control system for traffic light founding on fog computing. It calculates and shares the traffic flux situation at the intersection and the surrounding intersection through fog computing platform. Regarding the traffic flow at the intersection and the traffic flow at the surrounding intersection as the parameters, the intelligent control algorithm of traffic light is designed for achieving mutual coordination and mutual influence between different intersections, so that the traffic efficiency of each intersection is improved and the traffic flow of the entire transport network is alleviated. The simulation results showed this intelligent control system progress the traffic efficiency of every intersection and relieve the traffic flow of the whole transport network. | WU Qiong HE Fanfan FAN Xiumei | 2018 | Chinese Journal of Electronics2018，27，6： | 7 |
| 7 | Paleoproterozoic glaciation: Evidence from carbon isotope record of the Hutuo Group, Wutai Mountain area of Shanxi Province, China显示文摘Palaeoproterozoic 全球冻结成冰(2.3 Ga ) 可以是地球历史上的第一个雪球地球事件。诺思中国暴露得好沉积存款这次有最小的 postdepositional 的时期改变。一个冻结成冰事件的沉积证据然而一直在缺乏。这里,我们在 Wutai 山区分析了 Paleoproterozoic Hutuo 组(2.52.2 Ga ) 的碳同位素作文,山西省,诺思中国。我们的数据表演,在里面一对更年轻的 chronostratigraphic 顺序更旧,(1 ) 积极 13Ccarb 在 Doucun 亚群的 Dashiling 形成珍视(3.2 ~ 1.0, VPDB ) ;(2 ) 在 13Ccarb 的减少从 Wenshan 形成珍视到中间的 Daguandong 形成(从 2.0 to1.2 ) ,在哪个时间期间 stromatolites 的出现衰退了;(3 ) 在上面的 Daguandong 形成的一次显著否定旅行,在 Daguandong 和 Huaiyincun 形成的边界(从 1.4 ~ 3.3 ) ,在 stromatolites 消失了的地方;并且(4 ) 13Ccarb 的渐渐的增加在 Beidaxing 和 Tianpengnao 形成珍视(从 1.2 ~ 1.4 ) ,在哪个期间时间 stromatolites 回来了。我们主张否定的碳同位素旅行从 Jianancun 形成记录了到 Hutuo 组的中间的 Daguandong 形成可以是对 Palaeoproterozoic 全球冻结成冰的诺思瓷器反应。 | KONG FanFan YUAN XunLai ZHOU ChuanMing | 2011 | Chinese Science Bulletin2011，56，27： | 6 |
| 8 | Research progress on construction and energy storage performance of MXene heterostructures显示文摘MXenes are a family of two-dimensional (2D) transition metal carbides, carbonitrides/nitrides with superior physical and chemical properties, which have attracted extensive attention since the discovery in 2011. The impressive electrochemical activity of MXene makes it one of the most potential electrode materials in rechargeable batteries and supercapacitors. However, single-component MXene electrodes are difficult to achieve high specific capacity, efficient ion/electron transport, and high stability compatibility in an electrochemical environment. Studies have shown that it is an effective method to introduce nanomaterials between MXene layers to construct heterostructures and to improve the electrochemical performance through the synergistic effect among the components in the heterostructures. The introduction of nanomaterials can effectively suppress the restacking of MXene nanosheets, shorten the diffusion path of ions and promote the electrolyte transport, which is beneficial to enhance the rate performance of MXene;moreover, the excellent mechanical flexibility of MXene can reduce the volume expansion of nanomaterials during charge/discharge, thereby effectively protecting the integrity of the electrode structure and improving the cycling stability. Therefore, in this review, combined with theoretical calculations, we summarize the recent advances of MXene heterostructures in terms of synthesis strategies and energy storage applications, including supercapacitors, metal-ions batteries (Li, Na, K, Mg, Zn, Al) and metal anode protection. Furthermore, potential challenges and application perspectives for MXene heterostructures are also outlined. | Fanfan Liu Sen jin Qixun Xia Aiguo Zhou Li-Zhen Fan | 2021 | Journal of Energy Chemistry2021，30，11： | 5 |
| 9 | Alteration of heat shock protein 20 expression in preeclampticpatients and its effect in vascular and coagulation function显示文摘Preeclampsia (PE) is a pregnancy-specific, multi-system disorder and the leading cause of maternal andperinatal morbidity and mortality in obstetrics worldwide. Excessive vasoconstriction and dysregulatedcoagulation function are closely associated with PE. Heat shock protein 20 (HSP20) is ubiquitously expressedunder normal physiological conditions and has important roles in vascular dilatation and suppression of plateletaggregation. However, the role of HSP20 in the pathogenesis of PE remains unclear. In this study, we collectedchorionic plate resistance arteries (CPAs) and serum from 118 healthy pregnant women and 80 women with PEand detected the levels of HSP20 and its phosphorylated form. Both HSP20 and phosphorylated HSP20 weredownregulated in CPAs from women with PE. Comparison of the vasodilative ability of CPAs from the two groupsshowed impaired relaxation responses to acetyl choline in preeclamptic vessels. In addition to the reduced HSP20in serum from women with PE, the platelet distribution width and mean platelet volume were also decreased, andthe activated partial thromboplastin time and thromboplastin time were elevated. With regard to the vital roles ofHSP20 in mediating vasorelaxation and coagulation function, the decreased HSP20 might contribute to thepathogenesis of PE. | Fanfan Li Mengzhou He Meitao Yang Yao Fan Yun Chen Xi Xia Yin Xie Dongrui Deng | 2018 | Frontiers of Medicine2018，12，5： | 5 |
| 10 | The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells显示文摘 | Xue Zhu Lidan Xue Yong Yao Ke Wang Chengye Tan Miao Zhuang Fanfan Zhou Ling Zhu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 4 |
| 11 | Ionospheric disturbances associated with the 2015 M7.8 Nepal earthquake显示文摘Based on the total electron content(TEC) derived from Global Positioning System(GPS) observations of the Crustal Movement Observation Network of China(CMONOC) and the Global Ionosphere Map(GIM)from the Center for Orbit Determination in Europe(CODE),we detected and analyzed the ionospheric variations during the 2015 M7.8 Nepal earthquake(including the pre-earthquake ionospheric anomalies and coseismic ionospheric disturbances(CIDs) following the main shock).The analysis of vertical total electron content(VTEC) time series shows that the large-scale ionospheric anomalies appeared near the epicenter two days prior to the earthquake.Moreover,the pre-earthquake ionospheric anomalies were also observed in the geomagnetically conjugated region.In view of solar-terrestrial environment,the pre-earthquake ionospheric anomalies could be associated with the Nepal earthquake.In addition,we also detected the CIDs through the high-frequency GPS observation stations.The CIDs had obvious oscillated waveforms with the peak-to-peak disturbance amplitudes of about 1 TECu and 0.4 TECu,which propagated approximately with the horizontal velocities of 877 ± 75 m/s and 319 ± 30 m/s,respectively.The former is triggered directly by the acoustic waves which originated from the energy release of the earthquake near the epicenter,while the latter could be stimulated by the acoustic-gravity waves from the partial transformation of the acoustic waves. | Yiyan Zhou Jian Yang Fuying Zhu Fanfan Su Liangchen Hu Wenbo Zhai | 2017 | Geodesy and Geodynamics2017，8，4： | 4 |
| 12 | Self-standing Na-storage anode of Fe2O3 nanodots encapsulated in porous N-doped carbon nanofibers with ultra-high cyclic stability显示文摘 | Yongchang Liu Fanfan Wang Li-Zhen Fan | 2018 | Nano Research2018，11，8： | 3 |
| 13 | Integration of homogeneous and heterogeneous nucleation growth via 3D alloy framework for stable Na/K metal anode显示文摘Sodium/Potassium(Na/K)metal anodes have been considered as the promising anodes for next-generation Na/K secondary batteries owing to their ultrahigh specific capacity,low redox potential and low cost.However,their practical application is still hampered due to unstable solid electrolyte interphase,infinite volume change,and dendrite growth.Herein,we design a 3D-Na_(3)Bi/3D-K_(3)Bi alloy host which enables the homogeneous and heterogeneous nucleation growth of Na/K metal.The unique structure with periodic alternating of electron and ion conductivity improves the mass transfer kinetics and prevents the volume expansion during cycling.Meanwhile,the sodiophilicity of Na_(3)Bi/potassiophilicity of K_(3)Bi framework can avoid dendritic growth.Cycling lifespans over 700 h with 1 mAh cm^(−2)for 3D-Na_(3)Bi@Na electrode and about 450 h with 1 mAh cm^(−2)for 3D-K_(3)Bi@K electrode are achieved,respectively.3D-Na_(3)Bi@Na||Na_(3)V_(2)(PO_(4))3 full battery shows sustainable cycle performance over 400 cycles.This design provides a simple but effective approach for achieving safety of sodium/potassium metal anodes. | Shufen Ye Lifeng Wang Fanfan Liu Pengcheng Shi Yan Yu | 2021 | eScience2021，1，1： | 3 |
| 14 | Mode evolution and nanofocusing of grating-coupled surface plasmon polaritons on metallic tip显示文摘 | Fanfan Lu Wending Zhang Ligang Huang Shuhai Liang Dong Mao Feng Gao Ting Mei Jianlin Zhao | 2018 | Opto-Electronic Advances2018，1，6： | 3 |
| 15 | A new coordinated backup protection scheme for distribution network containing distributed generation显示文摘This paper proposes a new backup protection scheme,named coordinated backup protection(CBP)scheme,for distribution networks containing distributed generation.The proposed protection scheme takes into account the issues faced by traditional backup protection,such as difficulty in setting parameters and complex cooperation,and considers the features of distribution networks,such as changeable power flow because of high penetration of distributed generation sources and insufficient measuring quantities.The CBP scheme includes two aspects:coordinated substation protection and regional master substation protection,who also work as nearby backup protection and remote backup protection respectively.The two protections support each other by local information coordination and regional information sharing,in order to improve the reliability of fault identification.The configuration principles and performances of the proposed backup protection scheme are addressed in the paper.Different fault conditions in the IEEE 14-node system have been used to illustrate and verify the feasibility of the CBP scheme. | Jinghan He Lin Liu Fanfan Ding Changcheng Li Dahai Zhang | 2017 | Protection and Control of Modern Power Systems2017，2，1： | 3 |
| 16 | Effect of acupuncture treatment on smoking cessation in smokers from Hong Kong显示文摘OBJECTIVE: To analyze the characteristics of smokers treated with acupuncture for smoking cessation in Hong Kong.METHODS: A total of 2051 subjects were recruited in a clinical pilot research project 'acupuncture for smoking cessation', which was conducted jointly by Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences and Hong Kong Pok Oi Hospital from January of 2011 to December of 2013. The characteristics of study subjects, including baseline information, smoking background, intention to quit and influencing factors were analyzed.RESULTS: The majority of subjects treated with acupuncture for smoking cessation in Hong Kong was male(66.7%), but the proportion of female smokers in this study(33.3%) was higher than that of female smokers in Hong Kong population(13.8%, P <0.05). Subjects were at the mean age of 43.83 years old, of which the percentage of females aged 31-40 years was the highest(38.8%, P < 0.05). The mean duration of smoking was 25.49 years. The number of cigarettes smoked per day was 17.57 cigarettes.Fagerstrom Test for Nicotine Dependence(FTND)was 5.29 points. Most of the subjects had attempted quitting smoking(81.42%). The confidence index(7.44 points) and the readiness to quit smoking(8.13 points) were high. Subjects quitting smoking were mostly due to health cause(81.91%). The majority of subjects were at the level of middle school(61.63%). The higher the educational level was, the lower the tobacco dependence was and the higher the confidence in successfully quitting smoking was. 50.27% of subjects chose acupuncture for smoking cessation mainly through friends, television and network publicity. Subjects who had received acupuncture had the highest confidence index, while those who wanted to try a new method had the lower confidence index.CONCLUSION: Acupuncture for smoking cessation was more popular in female smokers, especially those aged 31-40 years. The effectiveness of acupuncture-smoking cessation was most significant in the smokers over 60. | Wang Yingying Liu Zhao Zhang Ou Chen Min Huang Lingling Wu Yuan Zhang Fanfan Wu Guanyi He Xiuqing Yang Jinsheng | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 3 |
| 17 | Azimuthal vector beam exciting silver triangular nanoprisms for increasing the performance of surface-enhanced Raman spectroscopy显示文摘Surface-enhanced Raman spectroscopy(SERS)with high-sensitivity performance is a very necessary detection technology.Here,we present a method for increasing the performance of SERS based on silver triangular nanoprism arrays(ATNAs)vertically excited via a focused azimuthal vector beam(AVB).The ATNA substrates with different structural parameters are prepared based on the traditional self-assembled and modified film lift-off technique.Based on a theoretical model established adopting the structural parameters of the ATNA substrates,theoretical simulation results show that AVB excitation can achieve greater electric-field enhancement than linearly polarized beam(LPB)excitation.Experimental result indicates that SERS sensitivity obtained via AVB excitation is 10^-13M(1 M=1 mol/L)using rhodamine 6 G(R6 G)as the target analyte,which is 2 orders of magnitude lower than that of LPB excitation(10^-11M).Meanwhile,the uniformity and reproducibility of the ATNA substrates are examined using Raman mapping and batch-to-batch measurement,respectively,and the Raman enhancement factor is calculated to be^3.3×10^7.This method of vector light field excitation may be used to improve the SERS performance of the substrates in fields of ultra-sensitive Raman detection. | LU ZHANG WENDING ZHANG FANFAN LU ZHIQIANG YANG TIANYANG XUE MIN LIU CHAO MENG PENG LI DONG MAO TING MEI JIANLIN ZHAO | 2019 | Photonics Research2019，7，12： | 3 |
| 18 | FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway显示文摘Docetaxel 为 non-small-cell 肺癌症(NSCLC ) 被推荐为一个第二线的化疗代理人;然而,药抵抗极大地限制它的效率。Forkhead 盒子 M1 (FoxM1 ) ,一个 oncogenic 抄写因素,被相信涉及各种各样的人的癌症的 chemoresistance;而有在 NSCLC 的获得的 docetaxel 抵抗的 FoxM1 的协会仍然保持不清楚。在现在的学习,我们在 docetaxel 抵抗的人的肺腺癌 A549 房间(A549/DTX ) 调查了 FoxM1 的参与。我们的结果证明那 FoxM1 表情显著地在父母 A549 房间与那相比在 A549/DTX 房间被增加。支持的 FoxM1 siRNA silencing 细胞毒素并且在 A549/DTX 房间的 docetaxel 的 pro-apoptotic 效果,它是可能通过导致 c6 月 N 终端 kinases/mitochondrial 发信号的激活调停了小径。我们的结果在 A549 房间的 docetaxel 抵抗建议 FoxM1 的一个关键角色并且在对待 NSCLC 为 docetaxel 和 FoxM1 弄空的联合治疗的发展形成基础。 | Ke Wang Xue Zhu Kai Zhang Ling Zhu Fanfan Zhou | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 2 |
| 19 | Experimental Study of Partially Demineralized Bone Matrix as Bone Tissue Engineering Scaffold显示文摘 | Lei Cui Dong Li Xiangdong Liu Fanfan Chen Wei Liu Yilin Cao | 2005 | 中国生物学文摘2005，19，10： | 2 |
| 20 | Ferrocene-induced switchable preparation of metal-nonmetal codoped tungsten nitride and carbide nanoarrays for electrocatalytic HER in alkaline and acid media显示文摘Transition metal nitride/carbide(TMN/C)have been actively explored as low-cost hydrogen evolution reaction(HER)electrocatalysts owing to their Pt-like physical and chemical properties.Unfortunately,pure TMN/C suffers from strong hydrogen adsorption and lacks active centers for water dissociation.Herein,we developed a switchable WO_(3)-based in situ gas–solid reaction for preparing sophisticated Fe-N doped WC and Fe-C doped WN nanoarrays.Interestingly,the switch of codoping and phase can be effectively manipulated by regulating the amount of ferrocene.Resultant Fe-C-WN and Fe-N-WC exhibit robust electrocatalytic performance for HER in alkaline and acid electrolytes,respectively.The collective collaboration of morphological,phase and electronic effects are suggested to be responsible for the superior HER activity.The smallest|ΔGH*|value of Fe-NWC indicates preferable hydrogen-evolving kinetics on the Fe-N-WC surface for HER under acid condition,while Fe-C-WN is suggested to be beneficial to the adsorption and dissociation of H_(2)O for HER in alkaline electrolyte. | Jian Zhou Fanfan Wang Haiqing Wang Shuxian Hu Weijia Zhou Hong Liu | 2023 | Nano Research2023，16，2： | 2 |
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