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| 1 | A study of miRNAs targets prediction and experimental validation显示文摘microRNAs(miRNAs)are 20–24 nucleotide(nt)RNAs that regulate eukaryotic gene expression post-transcriptionally by the degradation or translational inhibition of their target messenger RNAs(mRNAs).To identify miRNA target genes will help a lot by understanding their biological functions.Sophisticated computational approaches for miRNA target prediction,and effective biological techniques for validating these targets now play a central role in elucidating their functions.Owing to the imperfect complementarity of animal miRNAs with their targets,it is difficult to judge the accuracy of the prediction.Complexity of regulation by miRNA-mediated targets at protein and mRNAs levels has made it more challenging to identify the targets.To date,only a few miRNAs targets are confirmed.In this article,we review the methods of miRNA target prediction and the experimental validation for their corresponding mRNA targets in animals. | Yong Huang Quan Zou Haitai Song Fei Song Ligang Wang Guozheng Zhang Xingjia Shen | 2010 | Protein & Cell2010，1，11： | 7 |
| 2 | Bifurcation and chaos of the bladed overhang rotor system with squeeze film dampers显示文摘To study the nonlinear dynamic behavior of the bladed overhang rotor system with squeeze film damper (SFD), a blade-overhang rotor-SFD model is formulated using the lumped mass method and the Lagrange approach. The cavitated short bearing model is employed to describe the nonlinear oil force of the SFD. To reduce the scale of the nonlinear coupling system, a set of orthogonal transformations is employed to decouple the one nodal diameter equations of blades, which are coupled with the dy- namical equations of the rotor, with other equations of blades. In this way, the original system with 16+4n (n≥3) degrees of freedom (DoF) is reduced to a system with 24 DoF only. Then the parametric excitation terms in the blade-overhang rotor-SFD model are simplified in terms of periodic transforma- tions. The coupling equations are numerically solved and the solutions are used to analyze the dy- namic behavior of the system in terms of the bifurcation diagram, whirl orbit, Poincaré map and spec- trum plot. A variety of motion types are found such as multi-periodic, quasi-periodic, and chaotic mo- tions. Moreover, the typical nonlinear dynamic evolutions including the periodic-doubling bifurcation and reverse bifurcation are noted. It is noticed that there exist apparent differences in the dynamic behavior between the blade-overhang rotor-SFD models without and with considering the effect of blades. | CAO DengQing WANG LiGang CHEN YuShu HUANG WenHu | 2009 | Science China(Technological Sciences)2009，52，3： | 5 |
| 3 | Mode evolution and nanofocusing of grating-coupled surface plasmon polaritons on metallic tip显示文摘 | Fanfan Lu Wending Zhang Ligang Huang Shuhai Liang Dong Mao Feng Gao Ting Mei Jianlin Zhao | 2018 | Opto-Electronic Advances2018，1，6： | 3 |
| 4 | Plasmonic tip internally excited via an azimuthal vector beam for surface enhanced Raman spectroscopy显示文摘The synergy of a plasmonic tip and fiber-based structure light field excitation can provide a powerful tool for Raman examination. Here, we present a method of Raman spectrum enhancement with an Ag-nanoparticles(Ag-NPs)-coated fiber probe internally excited via an azimuthal vector beam(AVB), which is directly generated in a few-mode fiber by using an acoustically induced fiber grating. Theoretical analysis shows that gap mode can be effectively generated on the surface of the Ag-NPs-coated fiber probe excited via an AVB. The experimental result shows that the intensity of Raman signal obtained with analyte molecules of malachite green by exciting the Ag-NPs-coated fiber probe via an AVB is approximately eight times as strong as that via the linear polarization beam(LPB), and the activity of the AVB-excited fiber probe can reach 10^-11 mol∕L, which cannot be achieved by LPB excitation.Moreover, the time stability and reliability are also examined, respectively. | Min Liu Wending Zhang Fan fan Lu Tianyang Xue Xin Li Lu Zhang Dong Mao Ligang Huang Feng Gao Ting Mei Jianlin Zhao | 2019 | Photonics Research2019，7，5： | 3 |
| 5 | Selective Introduction of Carbazole and Diphenylamine into Spirofluorenexanthene Core for Different Phosphorescent Hosts显示文摘Built on the spiro[fluorene-9,9'-xanthene] (SFX) core and two frequently-used hole-transporting groups such ascarbazole and diphenylamine, two SFX derivatives, namely SFXCz and SFXDPA, have been synthesized byone-step reaction for red, green and blue phosphorescent organic light-emitting devices (PHOLEDs). Though theproperties of these two groups are very similar, the devices based on SFXCz and SFXDPA exhibit distinct perfor-mances. In blue PHOLEDs, the device based on SFXCz exhibited much better performances than that based onSFXDPA. However, the latter was superior to the former in green and red PHOLEDs. And the red PHOLED basedon SFXDPA exhibited maximum current efficiency (CE) of 27.1 cdoA^-l, power efficiency (PE) of 25.01m·W^-1, andexternal quantum efficiency (EQE) of 15.0%. The results show that the introduction of diphenylamine group issuitable for constructing green and red host materials, whereas the introduction of carbazole group is suitable forconstructing blue host materials. | Mingli Sun Shouzhen Yue Hongtao Cao Changjin Ou Yan Qian Ting Wang Ligang Chen Yi Zhao Wei Huang | 2016 | Chinese Journal of Chemistry2016，34，8： | 3 |
| 6 | Dynamic thermal coupling modeling and analysis of wet electro-hydrostatic actuator显示文摘The electro-hydrostatic actuator(EHA)used in more electric aircraft(MEA)has been extensively studied due to its advantages of high reliability and high integration.However,this high integration results in a small heat dissipation area,leading to high-temperature problems.Generally,to reduce the temperature,a wet cooling method of using the pump leakage oil to cool the motor is adopted,which can also increase the difficulty of accurately predicting the system temperature in the early design stage.To solve this problem,a dynamic coupling thermal model of a wet EHA is proposed in this paper.In particular,the leakage oil of the pump is used as a coupling item between the electrical system and the hydraulic system.Then,an improved T-equivalent block model is proposed to address the uneven distribution of axial oil temperature inside the motor,and the control node method is applied to hydraulic system thermal modeling.Meanwhile,a dynamic coupling thermal model is developed that enables a dynamic evaluation of the wet EHA temperature.Then,experimental prototypes of wet motor and wet EHA are developed,while the temperature response of the wet motor at different rotation speeds and different loads and the temperature response of the wet EHA at no-load condition were verified experimentally at room temperature,respectively.The maximum temperature difference between the experimental and theoretical results of the wet motor as well as the experimental and theoretical results of the wet EHA is less than 8℃.These test results indicate that the dynamic coupling thermal model is valid and demonstrate that the thermal coupling modeling method proposed in this paper can provide a basis for the detailed thermal design of EHA. | Zongxia JIAO Yanpeng LI Tian YU Chaofan JIANG Ligang HUANG Yaoxing SHANG | 2022 | Chinese Journal of Aeronautics2022，35，6： | 2 |
| 7 | The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility显示文摘PIWI-clade proteins harness pi RNAs of 24–33 nt in length.Of great puzzles are how PIWI-clade proteins incorporate pi RNAs of different sizes and whether the size matters to PIWI/pi RNA function.Here we report that a PIWI-Ins module unique in PIWIclade proteins helps define the length of pi RNAs.Deletion of PIWI-Ins in Miwi shifts MIWI to load with shorter pi RNAs and causes spermiogenic failure in mice,demonstrating the functional importance of this regulatory module.Mechanistically,we show that longer pi RNAs provide additional complementarity to target m RNAs,thereby enhancing the assembly of the MIWI/e IF3f/Hu R super-complex for translational activation.Importantly,we identify a c.1108C>T(p.R370W)mutation of HIWI(human PIWIL1)in infertile men and demonstrate in Miwi knock-in mice that this genetic mutation impairs male fertility by altering the property of PIWI-Ins in selecting longer pi RNAs.These findings reveal a critical role of PIWI-Ins-ensured longer pi RNAs in fine-tuning MIWI/pi RNA targeting capacity,proven essential for spermatid development and male fertility. | Xin Wang Di-Hang Lin Yue Yan An-Hui Wang Jiaoyang Liao Qian Meng Wen-Qing Yang Heng Zuo Min-Min Hua Fengjuan Zhang Hongwen Zhu Hu Zhou Tian-Yu Huang Rui He Guangyong Li Yue-Qiu Tan Hui-Juan Shi Lan-Tao Gou Dangsheng Li Ligang Wu Yonggang Zheng Xiang-Dong Fu Jinsong Li Rujuan Liu Guo-Hui Li Mo-Fang Liu | 2023 | Science China(Life Sciences)2023，66，7： | 2 |
| 8 | Graphene aerogel supported Pt-Ni alloy as efficient electrocatalysts for alcohol fuel oxidation显示文摘Alcohol fuels oxidation plays a significant role in carbon sustainable cycling and high-performance cata-lyst with a strong anti-poisoning effect is desired.Herein,Pt-Ni alloy supported on the N-doped graphene aerogel synthesized by simple freeze-drying and annealing was demonstrated to have such catalytic abil-ity for alcohol fuel oxidation.Pt-Ni alloy particles were found uniformly dispersed over the surface of 3D N-doped graphene aerogel.High anti-poisoning ability for CO-like intermediates oxidation was demon-strated by the CO-stripping experiment.The as-prepared catalyst was found to have outstanding catalytic performance for methanol and ethanol oxidation with high catalytic activity,stability and catalytic ki-netics.Compared to the control samples,the improved catalytic ability could be due to the presence of oxophilic Ni species and the support effect of 3D N-doped graphene aerogel that combined multi-advantages of large surface area,facile mass transfer,and abundant defects. | Xiang Ding Meng Li Junling Jin Xiaobing Huang Xiang Wu Ligang Feng | 2022 | Chinese Chemical Letters2022，33，5： | 2 |
| 9 | Influence of Reaction Conditions on Methanol Synthesis and WGS Reaction in the Syngas-to-DME Process显示文摘一系列 CuO-ZnO 催化剂(与不同 Cu/Zn 摩尔比率) 与三种 feed 气体和不同空间速度在 syngas-to-dimethyl 醚(DME ) 的反应条件下面被准备,并且评估。催化剂被 X 射线衍射(XRD ) 和规划温度的减小(TPR ) 描绘。实验结果证明 syngas-to-DME 过程的反应条件极大地影响了甲醇合成和 WGS 反应。Cu/Zn 摩尔比率引起的影响在二反应上是相当不同的;CO2 的百分比增加在喂气体为催化剂活动是相反的,并且也禁止了两反应;反应空间速度的改进重重地影响了催化剂的表演,并且好处是相对为甲醇合成的更少比为 WGS 反应。给词调音:铜;锌;Cu/Zn 摩尔比率;甲醇;暗淡乙醇醚;水煤气转移反应;syngas; | Ligang Wang Deren Fang Xingyun Huang Shigang Zhang Yue Qi Zhongmin Liu | 2006 | Journal of Natural Gas Chemistry2006，15，1： | 2 |
| 10 | An Ancient Concept in Traditional Chinese Medicine Provides a Therapeutic Theory for the Prevention of Type 2 Diabetes显示文摘 | Yin Xin NJ LJS Huang Wenjin ZT Ligang Zhou | 2013 | International Integrative Medicine2013，，57： | 1 |
| 11 | Nonlinear coupled dynamics of flexible blade–rotor–bearing systems显示文摘 | Ligang Wang D.Q. Cao Wenhu Huang | 2009 | Tribology International2009，，4： | 1 |
| 12 | Characteristics of diffuse source N pollution in Lean River catchment显示文摘 | Huang Lingguang Xu Ligang XIA YU | 2011 | Procedia Environmental Sciences2011，10，： | 1 |
| 13 | Spectrum evolution of Rayleigh backscattering in one‐dimensional waveguide显示文摘Despite the tremendous awareness of Rayleigh scattering characteristics and its considerable research interest for numerous fields,no report has been documented on the dynamic characteristics of spectrum evolution(SpE)and physical law for Rayleigh scattering from a micro perspective.Herein,the dynamic characteristics of the SpE of Rayleigh scattering in a one-dimensional waveguide(ODW)is investigated based on the quantum theory and a SpE-model of Rayleigh backscattering(RBS)source is established.By means of simulation,the evolution law which represents the dynamic process of the spectrum linewidth at a state of continuous scattering is revealed,which is consistent with our previous experimental observation.Moreover,an approximate theoretical prediction of the existing relationship between the spectrum linewidth of RBS source and the transmission length in ODW is proposed,which theoretically provides the feasibility of constructing functional devices suitable to ascertain laser linewidth compression.The designed experimental scheme can be implemented provided the assumptions are fulfilled.In addition,a theoretical model of the micro-cavity structure to realize the deep compression of laser linewidth is proposed. | Fuhui Li Tianyi Lan Ligang Huang Iroegbu Paul Ikechukwu Wuming Liu Tao Zhu | 2019 | Opto-Electronic Advances2019，2，8： | 1 |
| 14 | Chemicalcomposition and antifungal activity of the fruit oil of Zanthoxylumbungeanum Maxim,(Rutaceae)from China显示文摘 | GONG Youwen HUANG Yongfu ZHOU Ligang | 2009 | J Essent Oil Res2009，21，2： | 1 |
| 15 | Nonlinear coupled dynamics of flexible blade-rotor-bearing systems 显示文摘 | Wang Ligang Cao Dengqing Huang Wenhu | 2010 | Tribology International2010，43，4： | 1 |
| 16 | Nonlinear coupled dynamics of flexible blade–rotor–bearing systems显示文摘 | Ligang Wang D.Q. Cao Wenhu Huang | 2009 | Tribology International2009，，4： | 1 |
| 17 | Pay-it-forward gonorrhea and chlamydia testing among men who have sex with men in China:a study protocol for a three-arm cluster randomized controlled trial显示文摘Background:Gonorrhea and chlamydia testing rates are poor among Chinese men who have sex with men(MSM).A quasi-experimental study suggested that a pay-it-forward strategy increased dual gonorrhea/chlamydia testing among MSM.Pay-it-forward offers an individual a gift(e.g.,a free test)and then asks the same person if they would like to give a gift to another person.This article reports the protocol of a randomized controlled trial to evaluate dual gonorrhea/chlamydia test uptake and other outcomes among MSM in three arms-a pay-it-forward arm,a pay-what-you-want arm,and a standard of care arm.Methods:Three hundred MSM will be recruited at three HIV testing sites in Guangzhou and Beijing.Testing sites include two hospital-based MSM sexually transmitted diseases clinics and one MSM community-based organization.Eligible participants will be born biologically male,aged 16 years or older,reporting previous anal sex with another man,having never participated in the pay-it-forward program,without previous gonorrhea and chlamydia testing in the past 12 months,and residing in China.Following a cluster randomized design,every cluster of ten participants will be randomly allocated into one of three arms:(1)a pay-it-forward arm in which men are offered free gonorrhea and chlamydia testing and then asked whether they would like to donate('pay it forward')toward testing for future testers;(2)a pay-what-you-want arm in which men are offered free testing and told to decide how much to pay after receiving the test;(3)a standard of care arm in which men can pay the full price for dual gonorrhoea and chlamydia testing.The primary outcome is dual gonorrhoea/chlamydia testing as verified by administrative records.Secondary outcomes include incremental cost per test,incremental cost per diagnosis,community connectedness,and social cohesion.Primary outcome will be calculated for each arm using intention-to-treat and compared using one-sided 95%confidence intervals with a margin of 20%increase defined as superiority.Discussion:This study will examine the pay-it-forward strategy in comparison to the standard of care in improving test uptake for gonorrhea and chlamydia.We will leverage the cluster randomized controlled trial to provide scientific evidence on the potential effect of pay-it-forward.Findings from this study will shed light on novel intervention methods for increasing preventive health service utilization and innovate ways to finance it among communities.Trial registration:ClinicalTrials.gov,NCT03741725.Registered on 12 November 2018. | Tiange P.Zhang Fan Yang Weiming Tang Marcus Alexander Laura Forastiere Navin Kumar Katherine Li Fei Zou Ligang Yang Guodong Mi Yehua Wang Wenting Huang Amy Lee Weizan Zhu Peter Vickerman Dan Wu Bin Yang Nicholas A.Christakis Joseph D.Tucker | 2019 | Infectious Diseases of Poverty2019，8，4： | 1 |
| 18 | Nonlin- ear Coupled Dynamics of Flexible Blade-rotor-bear- ing Systems 显示文摘 | Wang Ligang Cao Dengqin Huang Wenhu | 2010 | Tribology International2010，43，4： | 1 |
| 19 | Polarization-modified Fano line shape spectrum with a single whispering gallery mode显示文摘Using the HE11Xand HE11Ymodes in a tapered fiber(TF)and the whispering gallery mode(WGM)in a microsphere resonator,Fano line-shape spectra were theoretically described and experimentally observed in this study.The line shapes of the spectra can be tuned to form a Lorentz notch,various Fano line shapes,and the Lorentz peak by controlling the polarizations at the input and output ports of the TF.The relative position or the size of the waveguide and WGM resonator do not need to be accurately controlled to produce these effects.The proposed configuration is suitable for mass production and will improve the performance of the devices in which it is applied. | PengFa Chang BoTao Cao LiGang Huang JiWei Li Yue Hu Feng Gao WenDing Zhang Fang Bo XuanYi Yu GuoQuan Zhang JingJun Xu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，1： | 1 |
| 20 | Photolarvicidal effect of thienyl 1, 3,4-thia (oxa) diazoles and their potential DNA photocleavage 显示文摘 | Qingchun Huang Ligang Liu Ciying Xiao | 2004 | Pesticide Biochemistry and Physiology2004，79，： | 1 |
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