| 1 | Microstructure evolution and texture tailoring of reduced graphene oxide reinforced Zn scaffold显示文摘Zinc(Zn)possesses desirable degradability and favorable biocompatibility,thus being recognized as a promising bone implant material.Nevertheless,the insufficient mechanical performance limits its further clinical application.In this study,reduced graphene oxide(RGO)was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing.Results showed that the homogeneously dispersed RGO simultaneously enhanced the strength and ductility of Zn scaffold.On one hand,the enhanced strength was ascribed to(i)the grain refinement caused by the pinning effect of RGO,(ii)the efficient load shift due to the huge specific surface area of RGO and the favorable interface bonding between RGO and Zn matrix,and(iii)the Orowan strengthening by the homogeneously distributed RGO.On the other hand,the improved ductility was owing to the RGO-induced random orientation of grain with texture index reducing from 20.5 to 7.3,which activated more slip systems and provided more space to accommodate dislocation.Furthermore,the cell test confirmed that RGO promoted cell growth and differentiation.This study demonstrated the great potential of RGO in tailoring the mechanical performance and cell behavior of Zn scaffold for bone repair. | Youwen Yang Yun Cheng Shuping Peng Liang Xu Chongxian He Fangwei Qi Mingchun Zhao Cijun Shuai | 2021 | Bioactive Materials2021，6，5： | 4 |
| 2 | Polygonatum sibiricum polysaccharides protect against obesity and non-alcoholic fatty liver disease in rats fed a high-fat diet显示文摘Polygonatum sibiricum is a traditional medicinal and dietary plant of the family Liliaceae. The main functional macromolecules of P. sibiricum are polysaccharides, which function in antioxidation and regulating immunity. Previous studies have shown that insulin resistance(IR), oxidative stress, and inflammation are important factors in the induction of lipid metabolic diseases such as obesity. Therefore, in this study, we established a high-fat diet-induced rat model of obesity and nonalcoholic fatty liver disease(NAFLD) to explore the potential protective effect of P. sibiricum polysaccharides(PSPs) and the mechanisms behind it. After 4 weeks of high-fat diet feeding to induce obesity, the rats were treated with different doses of PSP solution or distilled water for 6 weeks. Compared with untreated obese rats, PSP-treated obese rats showed a decrease in body weight, serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels, hepatic aspartate aminotransferase and alanine aminotransferase activity, hepatic malondialdehyde content, and hepatic levels of the pro-inflammatory factors tumor necrosis factor-α, interleukin-1β, and interleukin-6, as well as increased serum high-density lipoprotein cholesterol levels and hepatic superoxide dismutase, catalase, and glutathione peroxidase activity. Pathological analysis and immunoblotting of the liver tissues indicated that mechanistically, PSPs reduced obesity and NAFLD in rats by upregulating insulin receptor expression, increasing adenosine monophosphate-activated protein kinase phosphorylation, and downregulating sterol regulatory element-binding protein 2 and low-density lipoprotein receptor expression, thus promoting lipid metabolism, decreasing body weight, and reducing inflammation and oxidative stress caused by lipid accumulation. Based on these results, PSPs may have the potential to reduce obesity and NAFLD associated with a high-fat diet. | Li Zeng Fangwei Zhong Zhiliang Chen Gengxi Li Qi Zhu | 2022 | Food Science and Human Wellness2022，11，4： | 3 |
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